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15 p, 2.1 MB |
Genome-wide screening reveals the genetic basis of mammalian embryonic eye development
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Chee, Justine M. (Oakland University William Beaumont) ;
Lanoue, Louise (University of California Davis) ;
Clary, Dave (University of California Davis) ;
Higgins, Kendall (University of Miami) ;
Bower, Lynette (University of California Davis) ;
Flenniken, Ann (Lunenfeld-Tanenbaum Research Institute. Sinai Health (Canada)) ;
Guo, Ruolin (The Hospital for Sick Children (Canada)) ;
Adams, David J. (Wellcome Trust Sanger Institute (Regne Unit)) ;
Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG)) ;
Braun, Robert E. (The Jackson Laboratory) ;
Brown, Steve D. M. (Medical Research Council Harwell Institute (UK)) ;
Chin, Hsian-Jean Genie (National Applied Research Laboratories. National Laboratory Animal Center (Taiwan)) ;
Dickinson, Mary E. (Baylor College of Medicine. Department of Molecular and Human Genetics) ;
Hsu, Chih-Wei (Baylor College of Medicine. Department of Molecular and Human Genetics) ;
Dobbie, Michael (The John Curtin School of Medical Research (Australia)) ;
Gao, Xiang (Nanjing University. Nanjing Biomedical Research Institute) ;
Galande, Sanjeev (Indian Institutes of Science Education and Research) ;
Grobler, Anne (PCDDP North-West University (South Africa)) ;
Heaney, Jason D. (Baylor College of Medicine. Department of Molecular and Human Genetics) ;
Herault, Yann (Université de Strasbourg. Institut de Génétique et de Biologie Moléculaire et Cellulaire) ;
De Angelis, Martin Hrabe (Helmholtz Zentrum München. Institute of Experimental Genetics) ;
Mammano, Fabio (Italian National Research Council (Italy)) ;
Nutter, Lauryl M. J. (The Hospital for Sick Children (Canada)) ;
Parkinson, Helen (European Bioinformatics Institute (UK)) ;
Qin, Chuan (National Laboratory Animal Center. National Applied Research Laboratories (China)) ;
Shiroishi, Toshi (RIKEN BioResource Center (Japan)) ;
Sedlacek, Radislav (Institute of Molecular Genetics of the Czech Academy of Sciences. Czech Center for Phenogenomics) ;
Seong, J-K (Seoul National University. Research Institute for Veterinary Science) ;
Xu, Ying (Soochow University. CAM-SU Genomic Resource Center) ;
Brooks, Brian (National Eye Institute. Ophthalmic Genetics and Visual Function Branch (USA)) ;
McKerlie, Colin (University of Toronto. Department of Laboratory Medicine & Pathobiology) ;
Lloyd, K. C. Kent (University of California Davis. Department of Surgery, School of Medicine) ;
Westerberg, Henrik (Medical Research Council Harwell Institute (UK)) ;
Moshiri, Ala (UC Davis Eye Center (USA))
Background: Microphthalmia, anophthalmia, and coloboma (MAC) spectrum disease encompasses a group of eye malformations which play a role in childhood visual impairment. Although the predominant cause of eye malformations is known to be heritable in nature, with 80% of cases displaying loss-of-function mutations in the ocular developmental genes OTX2 or SOX2, the genetic abnormalities underlying the remaining cases of MAC are incompletely understood. [...]
2023 -  10.1186/s12915-022-01475-0
BMC biology, Vol. 21 (February 2023) , art. 22
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2.
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18 p, 2.3 MB |
Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes
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Pfrengle, Saskia (University of Tübingen. Institute of Evolutionary Medicine) ;
Neukamm, Judith (University of Tübingen. Institute for Archaeological Sciences) ;
Guellil, Meriam (University of Tartu. Estonian Biocentre, Institute of Genomics) ;
Keller, Marcel (University of Tartu. Institute of Genomics) ;
Molak, Martyna (University of Warsaw. Centre of New Technologies) ;
Avanzi, Charlotte (Colorado State University. Department of Microbiology, Immunology and Pathology) ;
Kushniarevich, Alena (University of Tartu. Institute of Genomics) ;
Montes, Núria (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Neumann, Gunnar U. (Max Planck Institute for the Science of Human History) ;
Reiter, Ella (University of Tübingen. Institute for Archaeological Sciences) ;
Tukhbatova, Rezeda I. (Max Planck Institute for the Science of Human History) ;
Berezina, Nataliya Y. (Moscow State University. Research Institute and Museum of Anthropology) ;
Buzhilova, Alexandra P. (Moscow State University. Research Institute and Museum of Anthropology) ;
Korobov, Dmitry S. (Russian Academy of Sciences. Institute of Archaeology) ;
Suppersberger Hamre, Stian (University of Bergen. Department of Archaeology, History, Cultural studies and religion) ;
Matos, Vitor M. J. (University of Coimbra. Department of Life Sciences) ;
Ferreira, Maria T. (Universidad de León. Departamento de Biodiversidad y Gestión Ambiental) ;
González-Garrido, Laura (Universidad de León. Departamento de Biodiversidad y Gestión Ambiental) ;
Wasterlain, Sofia N. (University of Coimbra. Department of Life Sciences) ;
Lopes, Célia (University of Coimbra. Department of Life Sciences) ;
Santos, Ana Luisa (University of Coimbra. Department of Life Sciences) ;
Antunes-Ferreira, Nathalie (Instituto Universitário Egas Moniz) ;
Duarte, Vitória (University of Coimbra. Department of Life Sciences) ;
Silva, Ana Maria (University of Coimbra. Department of Life Sciences) ;
Melo, Linda (University of Coimbra. Department of Life Sciences) ;
Sarkic, Natasa (OSTEO Research) ;
Saag, Lehti (University of Tartu. Institute of Genomics) ;
Tambets, Kristiina (University of Tartu. Institute of Genomics) ;
Busso, Philippe (Ecole Polytechnique Fédérale de Lausanne. Global Health Institute) ;
Cole, Stewart T. (Ecole Polytechnique Fédérale de Lausanne. Global Health Institute) ;
Avlasovich, Alexei (Mogilev State A. Kuleshov University. Department of Archeology, History of Belarus and Special Historical Disciplines) ;
Roberts, Charlotte A. (Durham University. Department of Archaeology) ;
Sheridan, Alison (National Museums Scotland. Department of Scottish History and Archaeology) ;
Cessford, Craig (University of Cambridge. Department of Archaeology) ;
Robb, John (University of Cambridge. Department of Archaeology) ;
Krause, Johannes (University of Tübingen. Institute for Archaeological Sciences) ;
Scheib, Christiana L. (University of Cambridge. St John's College) ;
Inskip, Sarah A. (University of Leicester. School of Archaeology and Ancient History) ;
Schuenemann, Verena J. (University of Tübingen. Senckenberg Centre for Human Evolution and Paleoenvironments)
Hansen's disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins and past dissemination patterns are still widely unknown. [...]
2021 - 10.1186/s12915-021-01120-2
BMC biology, Vol. 19 (2021) , art. 220
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4.
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17 p, 1.9 MB |
Alhagi sparsifolia acclimatizes to saline stress by regulating its osmotic, antioxidant, and nitrogen assimilation potential
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Ullah, Abd (University of Chinese Academy of Sciences) ;
Tariq, Akash (University of Chinese Academy of Sciences) ;
Sardans i Galobart, Jordi (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Peñuelas, Josep (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Zeng, Fanjiang (University of Chinese Academy of Sciences) ;
Graciano, Corina (Universidad Nacional de La Plata. Instituto de Fisiología Vegetal) ;
Asghar, Muhammad Ahsan (Agricultural Institute Centre for Agricultural Research) ;
Raza, Ali (University of Chinese Academy of Sciences. Chengdu Institute of Biology) ;
Xiong, You-Cai (Lanzhou University. Institute of Arid Agroecology, School of Life Sciences) ;
Chai, Xutian (University of Chinese Academy of Sciences) ;
Zhang, Zhihao (University of Chinese Academy of Sciences)
Alhagi sparsifolia (Camelthorn) is a leguminous shrub species that dominates the Taklimakan desert's salty, hyperarid, and infertile landscapes in northwest China. Although this plant can colonize and spread in very saline soils, how it adapts to saline stress in the seedling stage remains unclear so a pot-based experiment was carried out to evaluate the effects of four different saline stress levels (0, 50, 150, and 300 mM) on the morphological and physio-biochemical responses in A. [...]
2022 - 10.1186/s12870-022-03832-1
BMC plant biology, Vol. 22 (September 2022) , art. 453
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5.
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17 p, 5.0 MB |
Chromosome-level genome assemblies of four wild peach species provide insights into genome evolution and genetic basis of stress resistance
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Cao, Ke (Zhengzhou Fruit Research Institute) ;
Peng, Zhen (Novogene Bioinformatics Institute (Beijing)) ;
Zhao, Xing (Novogene Bioinformatics Institute (Beijing)) ;
Li, Yong (Zhengzhou Fruit Research Institute) ;
Liu, Kuozhan (Zhengzhou Fruit Research Institute) ;
Arús i Gorina, Pere (Centre de Recerca en Agrigenòmica) ;
Fang, Weichao (Zhengzhou Fruit Research Institute) ;
Chen, Changwen (Zhengzhou Fruit Research Institute) ;
Wang, Xinwei (Zhengzhou Fruit Research Institute) ;
Wu, Jinlong (Zhengzhou Fruit Research Institute) ;
Fei, Zhangjun (Cornell University. Boyce Thompson Institute for Plant Research) ;
Wang, Lirong (Zhengzhou Fruit Research Institute)
Peach (Prunus persica) is an economically important stone fruit crop in Rosaceae and widely cultivated in temperate and subtropical regions, emerging as an excellent material to study the interaction between plant and environment. [...]
2022 - 10.1186/s12915-022-01342-y
BMC biology, Vol. 20 (June 2022) , art. 139
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15 p, 3.6 MB |
Cross-communication between G and G in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain
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Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Brugarolas, Marc (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Moreno, Estefanía (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Aguinaga Andrés, David (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Pérez-Benito, Laura (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Ferré, Sergi (National Institutes of Health, Baltimore, USA) ;
Cortés, Antoni (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Casadó, Vicent (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Mallol, Josefa (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Canela, Enric I. (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Lluís, Carme (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
McCormick, Peter J. (Universitat de Barcelona) ;
Franco, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular)
G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (AR or AR) can form AR-AR heteromers (A-AHet), and their activation leads to canonical G-protein-dependent (adenylate cyclase mediated) and -independent (β-arrestin mediated) signaling. [...]
2018 - 10.1186/s12915-018-0491-x
BMC biology, Vol. 16 (february 2018)
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25 p, 3.4 MB |
Genomic evidence for recurrent genetic admixture during the domestication of Mediterranean olive trees (Olea europaea L.)
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Julca, Irene (Universitat Autònoma de Barcelona) ;
Marcet-Houben, Marina (Institute for Research in Biomedicine) ;
Cruz, Fernando (Centre de Regulació Genòmica) ;
Gómez-Garrido, Jessica (Centre de Regulació Genòmica) ;
Gaut, Brandon S. (University of California Irvine. Department Ecology and Evolutionary Biology) ;
Díez, Concepción M. (Universidad de Córdoba) ;
Gut, Ivo (Centre de Regulació Genòmica) ;
Alioto, Tyler Scott (Centre de Regulació Genòmica) ;
Vargas, Pablo, (Vargas Gómez) (Consejo Superior de Investigaciones Científicas. Real Jardín Botànico de Madrid) ;
Gabaldón, Toni (Institució Catalana de Recerca i Estudis Avançats)
Olive tree (Olea europaea L. subsp. europaea, Oleaceae) has been the most emblematic perennial crop for Mediterranean countries since its domestication around 6000 years ago in the Levant. Two taxonomic varieties are currently recognized: cultivated (var. [...]
2020 - 10.1186/s12915-020-00881-6
BMC biology, Vol. 18 (October 2020) , art. 148
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8.
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13 p, 1.3 MB |
Ecological, genetic and evolutionary drivers of regional genetic differentiation in Arabidopsis thaliana
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Castilla, Antonio R. (Consejo Superior de Investigaciones Científicas. Estación Biológica de Doñana. Departamento de Ecología Integrativa) ;
Méndez-Vigo, Belén (Consejo Superior de Investigaciones Científicas. Centro Nacional de Biotecnología. Departamento de Genética Molecular de Plantas) ;
Marcer, Arnald (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Martínez-Minaya, Joaquín (Basque Center for Applied Mathematics) ;
Conesa, David (Universitat de València. Departament d'Estadística i Investigació Operativa) ;
Picó, Xavier (Consejo Superior de Investigaciones Científicas. Estación Biológica de Doñana. Departamento de Ecología Integrativa) ;
Alonso-Blanco, Carlos (Consejo Superior de Investigaciones Científicas. Centro Nacional de Biotecnología. Departamento de Genética Molecular de Plantas)
Disentangling the drivers of genetic differentiation is one of the cornerstones in evolution. This is because genetic diversity, and the way in which it is partitioned within and among populations across space, is an important asset for the ability of populations to adapt and persist in changing environments. [...]
2020 - 10.1186/s12862-020-01635-2
BMC evolutionary biology, Vol. 20 (June 2020) , art. 71
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9.
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15 p, 6.7 MB |
The mutational landscape of human olfactory G protein-coupled receptors
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Jimenez, Ramón Cierco (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Casajuana-Martin, Nil (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
García Recio, Ädrian (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Alcántara, Lidia (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Campillo Grau, María Mercedes (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ;
Gonzalez, Angel (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional)
Olfactory receptors (ORs) constitute a large family of sensory proteins that enable us to recognize a wide range of chemical volatiles in the environment. By contrast to the extensive information about human olfactory thresholds for thousands of odorants, studies of the genetic influence on olfaction are limited to a few examples. [...]
2021 - 10.1186/s12915-021-00962-0
BMC biology, Vol. 19 (february 2021)
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10.
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14 p, 6.0 MB |
Structural and functional analysis of tomato sterol C22 desaturase
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Gutiérrez-García, Laura (Centre de Recerca en Agrigenòmica) ;
Arró i Plans, Montserrat (Centre de Recerca en Agrigenòmica) ;
Altabella Artigas, Teresa (Centre de Recerca en Agrigenòmica) ;
Ferrer, Albert (Centre de Recerca en Agrigenòmica) ;
Boronat i Margosa, Albert (Centre de Recerca en Agrigenòmica)
Background: Sterols are structural and functional components of eukaryotic cell membranes. Plants produce a complex mixture of sterols, among which β-sitosterol, stigmasterol, campesterol, and cholesterol in some Solanaceae, are the most abundant species. [...]
2021 - 10.1186/s12870-021-02898-7
BMC plant biology, Vol. 21 (March 2021) , art. 141
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