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15 p, 3.5 MB |
Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
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Kobayashi-Ishihara, Mie (Keio University School of Medicine) ;
Frazão Smutná, Katarína (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Alonso, Florencia E. (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Argilaguet, Jordi 1977- (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Esteve-Codina, Anna (Centre de Regulació Genòmica) ;
Geiger, Kerstin (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Genescà Ferrer, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Grau Expósito, Judith (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rogenmoser, Selina (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Böttcher, René (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Jungfleisch, Jennifer (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Oliva Miguel, Baldomero (Universitat Pompeu Fabra. Structural Bioinformatics Group) ;
Martinez, Javier P. (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Li, Manqing (University of California San Diego. Section of Molecular Biology) ;
David, Michael (University of California San Diego. Moores Cancer Center) ;
Yamagishi, Makoto (The University of Tokyo. Graduate School of Frontier Sciences) ;
Ruiz Riol, Marta (CIBER de Enfermedades Infecciosas) ;
Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ;
Tsunetsugu-Yokota, Yasuko (Tokyo University of Technology. Department of Medical Technology) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Díez, Juana (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Meyerhans, Andreas (Institució Catalana de Recerca i Estudis Avançats)
Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood. Here we describe the Schlafen 12 protein (SLFN12) as an HIV-1 restriction factor that establishes a post-transcriptional block in HIV-1-infected cells and thereby inhibits HIV-1 replication and virus reactivation from latently infected cells. [...]
2023 -  10.1038/s42003-023-04841-y
Communications Biology, Vol. 6 (may 2023)
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15 p, 1.7 MB |
Acolhimento, Redes sociais e produção do cuidado na Atenção Básica em Saúde no Município do Rio de Janeiro, Brasil
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Silva, Tarciso Feijó da (Universidade do Estado do Rio de Janeiro (Brasil) ;
David, Helena Maria Scherlowski Leal (Universidade do Estado do Rio de Janeiro (Brasil))
Estudo descritivo, com abordagem quantitativa, delineado por análise a partir da construção de relações entre atores na perspectiva da produção do cuidado na Atenção Básica em Saúde do Município do Rio de Janeiro. [...]
Descriptive study, with a quantitative approach, outlined by the analysis of the relationships of health professionals in a Primary Care unit in the city of Rio de Janeiro whose objectives were to identify, from the reception, the social networks of the actors for the production of care in Primary Care in Health and to characterize the existing relationships / interactions according to the degree of centrality, proximity and intermediation. [...]
2021 - 10.5565/rev/redes.879
Redes : revista hispana para el análisis de redes sociales, Vol. 32 Núm. 1 (2021) , p. 67-81 (Aglomeraciones)
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9 p, 1.3 MB |
Limited risk of Zika virus transmission by five Aedes albopictus populations from Spain
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González, M. A. (Instituto Oswaldo Cruz. Fundação Oswaldo Cruz (IOC/ FIOCRUZ). Laboratório de Mosquitos Transmissores de Hematozoários) ;
Pavan, M. G. (Fundação Oswaldo Cruz (Brasil)) ;
Fernandes, Rosilainy S. (Instituto Oswaldo Cruz) ;
Busquets, Núria (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
David, M. R. (Fundação Oswaldo Cruz (Brasil)) ;
Lourenço-de-Oliveira, Ricardo (Universidade Federal Do Rio de Janeiro. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular.) ;
García Pérez, Ana Luisa (NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario) ;
MacIel-De-Freitas, R. (Universidade Federal Do Rio de Janeiro. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular.)
Background: Aedes albopictus, the Asian tiger mosquito, is an exotic invasive species in Europe. It has substantial public health relevance due to its potential role in transmitting several human pathogens. [...]
2019 - 10.1186/s13071-019-3359-1
Parasites & vectors, Vol. 12 Núm. 1 (29 2019) , p. 150
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19 p, 449.6 KB |
Archetype analysis in sustainability research : meanings, motivations, and evidence-based policy making
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Oberlack, Christoph (University of Bern. Centre for Development and Environment (Switzerland)) ;
Sietz, Diana (Wageningen University (The Netherlands)) ;
Bonanomi, Elisabeth Bürgi (University of Bern. Centre for Development and Environment (Switzerland)) ;
De Bremond, Ariane (University of Maryland. Geographical Sciences Department (USA)) ;
Dell'Angelo, Jampel (Vrije Universiteit Amsterdam) ;
Eisenack, Klaus (Humboldt-Universität zu Berlin. Department für Agrarökonomie) ;
Ellis, Erle C. (University of Maryland. Department of Geography and Environmental Systems (USA)) ;
Epstein, Graham (University of Waterloo. Environmental Change and Governance Group (Canada)) ;
David, M. (School of Sustainability. Arizona state University) ;
Giger, Markus (University of Bern. Centre for Development and Environment (Switzerland)) ;
Heinimann, Andreas (University of Bern. Centre for Development and Environment (Switzerland)) ;
Kimmich, Christian (Masaryk University. Department of Environmental Studies (Czechia)) ;
Kok, Marcel T. J. (PBL Netherlands Environmental Assessment Agency) ;
Navarrete, David Manuel (Arizona state University (USA)) ;
Messerli, Peter (University of Bern. Centre for Development and Environment (Switzerland)) ;
Meyfroidt, Patrick (Université catholique de Louvain. Earth and Life Institute. Georges Lemaître Center for Earth and Climate Research (Belgium)) ;
Václavík, Tomáš (Palacký University Olomouc. Department of Ecology and Environmental Sciences (Czechia)) ;
Villamayor Tomás, Sergio (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals)
Archetypes are increasingly used as a methodological approach to understand recurrent patterns in variables and processes that shape the sustainability of social-ecological systems. The rapid growth and diversification of archetype analyses has generated variations, inconsistencies, and confusion about the meanings, potential, and limitations of archetypes. [...]
2019 - 10.5751/ES-10747-240226
Ecology and society, Vol. 24, Issue 2 (July 2019) , art. 26
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8 p, 788.7 KB |
A randomized phase III study of carfilzomib vs low-dose corticosteroids with optional cyclophosphamide in relapsed and refractory multiple myeloma (FOCUS)
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Hájek, R. (University Hospital Ostrava) ;
Masszi, T. (St László Hospital (Hongria)) ;
Petrucci, M. T. (Sapienza Università di Roma) ;
Palumbo, A. (Università di Torino) ;
Rosiñol, L. (Hospital Clínic i Provincial de Barcelona) ;
Nagler, Arnon. (Chaim Sheba Medical Center (Israel)) ;
Yong, K. L. (University College London Cancer Institute) ;
Oriol, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Minarik, J. (University Hospital Olomouc (Olomouc, República Txeca)) ;
Pour, L. (University Hospital Ostrava) ;
Dimopoulos, Meletios (The National and Kapodistrian University of Athens) ;
Maisnar, V. (Charles University. Faculty of Medicine in Hradec Králové) ;
Rossi, Davide (Amedeo Avogadro University of Eastern Piedmont) ;
Kasparu, H. (Ordensklinikum Linz Elisabethinen) ;
Van Droogenbroeck, J. (AZ Sint-Jan, Brugge, Belgium) ;
Yehuda, D. B. (Hadassah Medical Center, Jerusalem, Israel) ;
Hardan, I. (Meir Medical Center, Kfar-Saba, Israel) ;
Jenner, M. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Calbecka, M. (Nicolaus Copernicus Hospital, Toruń Poland) ;
Dávid, M. (University of Pécs, Hungary) ;
de la Rubia, Javier (Hospital Universitari i Politècnic La Fe (València)) ;
Drach, J. (Medical University of Vienna) ;
Gasztonyi, Z. (Petz Aladár Megyei Oktató Kórház, Vasvári Pál, Hungary) ;
Górnik, S. (Zamojski Szpital Niepubliczny, Zamosc, Poland) ;
Leleu, Xavier (Hopital Huriez, CHRU, Lille, France) ;
Munder, M. (University Medicine Mainz, Germany) ;
Offidani, M. (Clinica di Ematologia Azienda Ospedaliero-Universitaria, Ospedali Riuniti di Ancona, Italy) ;
Zojer, N. (Center for Oncology, Hematology with Outpatient Department and Palliative Care, Wilhelminenspital, Vienna, Austria) ;
Rajangam, K. (Onyx Pharmaceuticals, Inc.) ;
Chang, Y. L. (Onyx Pharmaceuticals, Inc.) ;
San-Miguel, J. F. (Clínica Universidad de Navarra. Centro de Investigación Médica Aplicada) ;
Ludwig, H. (Wilhelminen Cancer Research Institute (Viena, Àustria))
This randomized, phase III, open-label, multicenter study compared carfilzomib monotherapy against low-dose corticosteroids and optional cyclophosphamide in relapsed and refractory multiple myeloma (RRMM). [...]
2017 - 10.1038/leu.2016.176
Leukemia, Vol. 31 (2017) , p. 107-114
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