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10 p, 3.2 MB |
Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19
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Bruno, Raphael Romano (Heinrich Heine University Düsseldorf) ;
Wernly, Bernhard (Paracelsus Medical University Salzburg) ;
Wolff, Georg (Heinrich Heine University Düsseldorf) ;
Fjølner, Jesper (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Bollen Pinto, Bernardo (Geneva University Hospitals) ;
Schefold, Joerg C. (University of Bern) ;
Kindgen-Milles, Detlef (Heinrich Heine University Düsseldorf) ;
Baldia, Philipp Heinrich (Heinrich Heine University Düsseldorf) ;
Kelm, Malte (Medical Faculty of the Heinrich-Heine University) ;
Beil, Michael (Hebrew University of Jerusalem) ;
Sviri, Sigal (Hebrew University of Jerusalem) ;
van Heerden, Peter Vernon (Hebrew University of Jerusalem) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Topeli, Arzu (Hacettepe University Faculty of Medicine) ;
Elhadi, Muhammed (University of Tripoli) ;
Joannidis, Michael (Medical University Innsbruck) ;
Oeyen, Sandra (Universitair Ziekenhuis Gent) ;
Kondili, Eumorfia (University Hospital of Heraklion) ;
Marsh, Brian (Mater Misericordiae University Hospital(Dublín, Irlanda)) ;
Andersen, Finn H. (Norwegian University of Science and Technology) ;
Moreno, Rui (Nova Medical School) ;
Leaver, Susannah (St George's University Hospitals NHS Foundation Trust) ;
Boumendil, Ariane (Hôpital Saint-Antoine) ;
De Lange, Dylan W. (Utrecht University) ;
Guidet, Bertrand (Hôpital Saint-Antoine) ;
Flaatten, Hans (Haukeland University Hospital (Bergen, Noruega)) ;
Jung, Christian (Heinrich Heine University Düsseldorf) ;
Universitat Autònoma de Barcelona
Chronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID-19). This prospective international multicentre study investigates the role of pre-existing CHF on clinical outcomes of critically ill old (≥70 years) intensive care patients with COVID-19. [...]
2022 -  10.1002/ehf2.13854
ESC Heart Failure, Vol. 9 (march 2022) , p. 1756-1765
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2.
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5 p, 3.6 MB |
Prognostic role of NYHA class in heart failure patients undergoing primary prevention ICD therapy
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Briongos-Figuero, S. (Hospital Universitario Infanta Leonor) ;
Estévez, A. (Hospital Universitario Infanta Leonor) ;
Pérez, M.L. (Complejo Hospitalario Universitario de A Coruña) ;
Martínez-Ferrer, José Bautista (Arabako Unibertsitate Ospitalea (Vitoria, País Basc)) ;
García, E. (Complexo Hospitalario Universitario de Vigo) ;
Viñolas Prat, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Arenal Maiz, Ángel (Hospital General Universitario Gregorio Marañón) ;
Alzueta, J. (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Muñoz-Aguilera, R. (Hospital Universitario Infanta Leonor) ;
Universitat Autònoma de Barcelona
Concerns about the prognostic value of NYHA functional class (FC) in heart failure (HF) patients carrying a prophylactic implantable cardioverter defibrillator (ICD) are still present. We aimed to compare whether mortality and arrhythmic risk were different, in a cohort of HF patients undergoing ICD-only implant, according to their FC. [...]
2020 - 10.1002/ehf2.12548
ESC Heart Failure, Vol. 7 Núm. 1 (january 2020) , p. 279-283
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3.
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7 p, 2.2 MB |
Therapeutic inertia in the pharmacological management of heart failure with reduced ejection fraction
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Girerd, Nicolas (F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists)) ;
Von Hunolstein, Jean-Jacques (Strasbourg University Hospital) ;
Pellicori, Pierpaolo (University of Glasgow) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona) ;
Jaarsma, Tiny (Linköping University) ;
Lund, Lars H. (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Bilbault, Pascal (University of Strasbourg) ;
Boivin, Jean-Marc (Université de Lorraine) ;
Chouihed, Tahar (University Hospital of Nancy) ;
Costa, Jérôme (Centre hospitalo-universitaire de Reims) ;
Eicher, Jean-Christophe (CHU Dijon) ;
Fall, Estelle (Université de Lorraine) ;
Kenizou, David (Hôpital Emile Muller) ;
Maillier, Bruno (Centre hospitalier de Troyes) ;
Nazeyrollas, Pierre (Centre hospitalo-universitaire de Reims) ;
Roul, Gérald (Hôpitaux Universitaires de Strasbourg) ;
Zannad, Noura (Regional Hospital, Mercy Hospital) ;
Rossignol, Patrick (Cardiovascular and Renal Clinical Trialists) ;
Seronde, Marie-France (University of Burgundy Franche-Comté Besançon) ;
universitat Autònoma de Barcelona
2022 - 10.1002/ehf2.13929
ESC Heart Failure, Vol. 9 (april 2022) , p. 2063-2069
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4.
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10 p, 1.6 MB |
Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy : results of an international multicentre registry
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Gimeno, Juan R. (Center for Biomedical Network Research on Cardiovascular Diseases (CIBERCV)) ;
Olivotto, Iacopo (Careggi University Hospital (Florència, Itàlia)) ;
Rodríguez, Ana Isabel (European Reference Networks for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart)) ;
Ho, Carolyn Y. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Fernández, Adrián (Favaloro Foundation University Hospital) ;
Quiroga, Alejandro (Favaloro Foundation University Hospital) ;
Espinosa, Mari Angeles (Hospital General Universitario Gregorio Marañón) ;
Gómez-González, Cristina (Hospital General Universitario Gregorio Marañón) ;
Robledo, María (Hospital Universitario Araba (Txagorritxu)) ;
Tojal-Sierra, Lucas (Hospital Universitario Araba (Txagorritxu)) ;
Day, Sharlene M. (Hospital of the University of Pennsylvania) ;
Owens, Anjali (Hospital of the University of Pennsylvania) ;
Barriales-Villa, Roberto (Complejo Hospitalario Universitario de A Coruña) ;
Larrañaga, Jose María (Complejo Hospitalario Universitario de A Coruña) ;
Rodriguez-Palomares, Jose F (Hospital Universitari Vall d'Hebron) ;
González-del-Hoyo, Maribel (Hospital Universitari Vall d'Hebron) ;
Piqueras-Flores, Jesús (Hospital General Universitario de Ciudad Real) ;
Reza, Nosheen (Hospital of the University of Pennsylvania) ;
Chumakova, Olga (Municipal Clinical Hospital #17) ;
Ashley, Euan A. (Stanford University Medical Center) ;
Parikh, Victoria (Stanford University Medical Center) ;
Wheeler, Matthew (Stanford University Medical Center) ;
Jacoby, Daniel (Yale New Haven Hospital) ;
Pereira, Alexandre C. (Hospital das Clinicas da Univerisidade de Sao Paulo) ;
Saberi, Sara (University of Michigan Hospital) ;
Helms, Adam S. (University of Michigan Hospital) ;
Villacorta, Eduardo (Universidad de Salamanca) ;
Gallego-Delgado, María (Universidad de Salamanca) ;
de Castro, Daniel (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Domınguez, Fernando (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Ripoll-Vera, Tomás (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Zorio, Esther (Hospital Universitari i Politècnic La Fe (València)) ;
Sánchez-Martínez, José Carlos (Hospital Universitari i Politècnic La Fe (València)) ;
García-Álvarez, Ana (Hospital Clínic i Provincial de Barcelona) ;
Arbelo, Elena (Hospital Clínic i Provincial de Barcelona) ;
Mogollón, María Victoria (Hospital San Pedro de Alcántara) ;
Fuentes-Cañamero, María Eugenia (Badajoz University Hospital) ;
Grande, Elias (Dilemma Solution S.L) ;
Peña, Carlos (Dilemma Solution S.L) ;
Monserrat, Lorenzo (Dilemma Solution S.L) ;
Lakdawala, Neal K. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Universitat Autònoma de Barcelona
To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events. Three hundred and five patients [age 56. [...]
2022 - 10.1002/ehf2.13964
ESC Heart Failure, Vol. 9 (june 2022) , p. 2189-2198
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5.
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11 p, 1.8 MB |
Sacubitril/valsartan affects pulmonary arterial pressure in heart failure with preserved ejection fraction and pulmonary hypertension
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Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Barceló, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gastelurrutia, Paloma (Institut d'Investigació Biomèdica de Bellvitge) ;
Casquete, Daniel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vila, Joan (Hospital del Mar (Barcelona, Catalunya)) ;
Abdul-Jawad Altisent, Omar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Spitaleri, Giosafat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santiago Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Zamora, Elisabet (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Cueto, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santesmases, Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De la Espriella, Rafael (Universitat de València) ;
Pascual-Figal, Domingo A. (Centro Nacional de Investigaciones cardiovasculares (CNIC)) ;
Núñez, Julio (Universitat de València) ;
Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Prior studies have not fully characterized the haemodynamic effects of the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan in heart failure with preserved ejection fraction and pulmonary hypertension (HFpEF-PH). [...]
2022 - 10.1002/ehf2.13952
ESC Heart Failure, Vol. 9 (may 2022) , p. 2170-2180
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10 p, 461.9 KB |
Quality of life in patients with heart failure and improved ejection fraction : one-year changes and prognosis
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Zamora, Elisabet (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González Fernández, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Borrellas, Andrea (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santiago Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rivas, Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pulido, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Crespo, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Velayos, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Díaz, Violeta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The criteria for patients with heart failure (HF) and improved ejection fraction (HFimpEF) are a baseline left ventricular ejection fraction (LVEF) ≤40%, a ≥10-point increase from baseline LVEF, and a second LVEF measurement >40%. [...]
2022 - 10.1002/ehf2.14098
ESC Heart Failure, Vol. 9 (august 2022) , p. 3804-3813
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4 p, 85.7 KB |
Reparative cell therapy for the heart : critical internal appraisal of the field in response to recent controversies
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Povsic, T.J. (Duke Clinical Research Institute. Duke University School of Medicine) ;
Sanz-Ruiz, R. (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Climent, A.M. (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Bolli, R. (Department of Medicine. School of Medicine. University of Louisville) ;
Taylor, D.A. (Center for Cell and Organ Biotechnology. Texas Heart Institute) ;
Gersh, B.J. (Department of Cardiovascular Medicine. Mayo Clinic College of Medicine) ;
Menasché, P. (Department of Cardiovascular Surgery. Georges Pompidou European Hospital) ;
Perin, E.C. (Center for Clinical Research. Texas Heart Institute) ;
Pompilio, G. (Vascular Biology and Regenerative Medicine Unit and Dept. of Cardiovascular Surgery. Centro Cardiologico Monzino IRCCS) ;
Atsma, D.E. (Faculteit der Sociale Wetenschappen. Instituut Psychologie. Gezondheids. Medische-Neuropsychologie) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
DeMaria, A.N. (Sulpizio Cardiovascular Center. UC San Diego Health) ;
Hare, J.M. (Interdisciplinary Stem Cell Institute and Division of Cardiology. Leonard M. Miller School of Medicine. University of Miami) ;
Henry, Timothy D (The Carl and Edyth Lindner Center for Research and Education. The Christ Hospital) ;
Janssens, S. (Centre for Molecular and Vascular Biology. Department of Cardiovascular Sciences. KU Leuven) ;
Kastrup, J. (Department of Cardiology. Centre for Cardiac. Vascular. Pulmonary and Infectious Diseases. Rigshospitalet) ;
Torella, D. (Molecular and Cellular Cardiology LAB. Department of Experimental and Clinical Medicine. Magna Graecia University) ;
Traverse, J.H. (Minneapolis Heart Institute Foundation. Abbott Northwestern Hospital) ;
Willerson, J.T. (Center for Clinical Research. Texas Heart Institute) ;
Fernández Avilés, F. (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
The concept that cell-based repair of myocardial injury might be possible was introduced almost two decades ago; however, the field of cardiovascular reparative medicine has been criticized as translation to clinically effective approaches has been slow. [...]
2021 - 10.1002/ehf2.13256
ESC Heart Failure, Vol. 8 Núm. 3 (june 2021) , p. 2306-2309
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10 p, 739.1 KB |
Time course, factors related to, and prognostic impact of venoarterial extracorporeal membrane flow in cardiogenic shock
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Montero, Santiago (Assistance Publique-Hôpitaux de Paris) ;
Rivas-Lasarte, Mercedes (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Huang, Florent (Assistance Publique-Hôpitaux de Paris) ;
Chommeloux, Juliette (Assistance Publique-Hôpitaux de Paris) ;
Demondion, Pierre (Sorbonne Université) ;
Bréchot, Nicolas (Sorbonne Université) ;
Hékimian, Guillaume (Sorbonne Université) ;
Franchineau, Guillaume (Sorbonne Université) ;
Persichini, Romain (Felix-Guyon Hospital) ;
Luyt, Charles-Edouard (Sorbonne Université) ;
Garcia Garcia, Cosme (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lebreton, Guillaume (Sorbonne Université) ;
Cinca, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Leprince, Pascal (Sorbonne Université) ;
Combes, Alain (Sorbonne Universités) ;
Alvarez-Garcia, Jesus (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Schmidt, Matthieu (Sorbonne Université) ;
Universitat Autònoma de Barcelona
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is currently one of the most used devices in refractory cardiogenic shock. However, there is a lack of evidence on how to set the 'optimal' flow. [...]
2022 - 10.1002/ehf2.14132
ESC Heart Failure, Vol. 10 (november 2022) , p. 568-577
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8 p, 5.6 MB |
Rationale and Design of the Efficacy of a Standardized Diuretic Protocol in Acute Heart Failure Study
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Dauw, Jeroen (UHasselt-Hasselt University. Doctoral School for Medicine and Life Sciences. LCRC) ;
Lelonek, Malgorzata (Department of Noninvasive Cardiology. Medical University of Lodz) ;
Zegrí-Reiriz, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Paredes-Paucar, Cynthia P. (Instituto Nacional de Cardiología Ignacio Chávez) ;
Zara, Cornelia (Theracardia Clinic) ;
George, Varghese (Pushpagiri Institute of Medical Sciences) ;
Cobo-Marcos, Marta (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Knappe, Dorit (Department of Cardiology. University Heart and Vascular Center Hamburg) ;
Shchekochikhin, Dimitry (Department of cardiology. sonography and functional diagnostics. First Moscow State Medical University) ;
Lekhakul, Annop (Wetchakarunrasm Hospital) ;
Klincheva, Milka (Zan Mitrev Clinic) ;
Frea, Simone (Division of Cardiology. Città della Salute e della Scienza University Hospital of Torino) ;
Miró, Oscar (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Barker, Diane (University Hospitals of North Midlands) ;
Borbély, Attila (Department of Cardiology. Faculty of Medicine. University of Debrecen) ;
Nasr, Samer (Department of Cardiology. Mount Lebanon Hospital-Balamand University Medical Center) ;
Doghmi, Nawal (Department of Cardiology. CHU Ibn Sina. Mohammed V University) ;
De la Espriella, Rafael (Hospital Clínic Universitari (València)) ;
Singh, Jagdeep S. (The Heart Centre. Royal Infirmary of Edinburgh) ;
Bovolo, Virginia (Department of Cardiology. Michele e Pietro Ferrero Hospital) ;
Fialho, Inês (Department of Cardiology. Hospital Doutor Fernando Fonseca) ;
Ross, Noel T. (Kuala Lumpur General Hospital) ;
van den Heuvel, Mieke (Department of Cardiology. Thorax Centrum Twente. Medisch Spectrum Twente) ;
Benkouar, Riad (Benyoucef Benkhedda Faculty of Medicine. Mustapha Pacha Hospital. University of Algiers) ;
Findeisen, Hajo (Department of Internal Medicine. Red Cross Hospital) ;
Alhaddad, Imad A. (Jordan Hospital) ;
Al Balbissi, Kais (Department of Cardiology. Abdali Hospital) ;
Barge-Caballero, Gonzalo (Instituto de Investigación Biomédica de A Coruña) ;
Ghazi, Azmee M. (National Heart Institute) ;
Bruckers, Liesbeth (I-BioStat. Data Science Institute. Hasselt University) ;
Martens, Pieter (Department of Cardiology. Ziekenhuis Oost-Limburg) ;
Mullens, Wilfried (Faculty of Medicine and Life Sciences. LCRC. UHasselt. Biomedical Research Institute) ;
Universitat Autònoma de Barcelona
Aims: Although acute heart failure (AHF) with volume overload is treated with loop diuretics, their dosing and type of administration are mainly based upon expert opinion. A recent position paper from the Heart Failure Association (HFA) proposed a step-wise pharmacologic diuretic strategy to increase the diuretic response and to achieve rapid decongestion. [...]
2021 - 10.1002/ehf2.13666
ESC Heart Failure, Vol. 8 Núm. 6 (december 2021) , p. 4685-4692
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11 p, 7.3 MB |
Lung ultrasound in outpatients with heart failure : the wet-to-dry HF study
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Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lupón, Josep (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Girerd, Nicolás (Centre d'Investigations Cliniques Plurithématique 1433. INSERM DCAC. CHRU de Nancy. F-CRIN INI-CRCT. Université de Lorraine) ;
Conangla, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
de Antonio Ferrer, Marta (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Moliner, Pedro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santiago-Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Spitaleri, Giosafat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Díaz, Violeta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rivas Jiménez, Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Velayos, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Núñez, Julio (Universitat de València. Departament de Medicina) ;
Bayés-Genís, Antoni (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Universitat Autònoma de Barcelona
Aims: In ambulatory patients with chronic heart failure (HF), congestion and decongestion assessment may be challenging. The aim of this study is to assess the value of lung ultrasound (LUS) in outpatients with HF in characterizing decompensation and recompensation, and in outcomes prediction. [...]
2021 - 10.1002/ehf2.13660
ESC Heart Failure, Vol. 8 Núm. 6 (december 2021) , p. 4506-4516
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