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15 p, 2.8 MB |
Association of candidate genetic variants and circulating levels of ApoE/ApoJ with common neuroimaging features of cerebral amyloid angiopathy
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Bonaterra-Pastra, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Benitez, Sonia (Institut d'Investigació Biomèdica Sant Pau) ;
Pancorbo, Olalla (Hospital Universitari Vall d'Hebron) ;
Rodriguez-Luna, David (Hospital Universitari Vall d'Hebron) ;
Vert, Carla (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Freijo, M. Mar (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Tur, Silvia (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Martínez-Zabaleta, Maite (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Cardona, Pere-Joan (Hospital Universitari de Bellvitge) ;
Vera, Rocío (Hospital Universitario Ramón y Cajal (Madrid)) ;
Lebrato-Hernández, Lucia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Arenillas, Juan F. (Universidad de Valladolid) ;
Pérez-Sánchez, Soledad (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Domínguez-Mayoral, Ana (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Martí-Fàbregas, Joan (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Mauri, Gerard (Hospital Universitari Arnau de Vilanova) ;
Montaner, Joan (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Sanchez-Quesada, Jose Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Hernandez Guillamon, Maria Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid-β (Aβ) in brain vessels and is a main cause of lobar intracerebral hemorrhage (ICH) in the elderly. CAA is associated with magnetic resonance imaging (MRI) markers of small vessel disease (SVD). [...]
2023 -  10.3389/fnagi.2023.1134399
Frontiers in aging neuroscience, Vol. 15 (april 2023)
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13.
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16 p, 5.9 MB |
Adult-specific Reelin expression alters striatal neuronal organization : implications for neuropsychiatric disorders
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Pardo, Mònica (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gregorio, Sara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Montalban, Enrica (Sorbonne University) ;
Pujadas, Lluís (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Elias-Tersa, Alba (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Masachs, Núria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Vílchez-Acosta, Alba (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Parent, Annabelle (Hospital Universitari Vall d'Hebron) ;
Auladell, Carme (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Girault, Jean-Antoine (Sorbonne University) ;
Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Nairn, Angus C. (Yale University School of Medicine) ;
Manso Sanz, Yasmina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Soriano García, Eduardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder. [...]
2023 - 10.3389/fncel.2023.1143319
Frontiers in cellular neuroscience, Vol. 17 (April 2023) , art. 1143319
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14.
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15.
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12 p, 1.6 MB |
Tele-supervised home-based transcranial alternating current stimulation (tACS) for Alzheimer's disease : a pilot study
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Cappon, Davide (Harvard Medical School) ;
Fox, Rachel (Deanna and Sidney Wolk Center for Memory Health at Hebrew SeniorLife) ;
den Boer, Tim (Hinda and Arthur Marcus Institute for Aging Research at Hebrew SeniorLife) ;
Yu, Wanting (Hinda and Arthur Marcus Institute for Aging Research at Hebrew SeniorLife) ;
LaGanke, Nicole (Hinda and Arthur Marcus Institute for Aging Research at Hebrew SeniorLife) ;
Cattaneo, Gabriele (Institut Germans Trias i Pujol. Institut Guttmann) ;
Perellón-Alfonso, Ruben (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Bartrés-Faz, David (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Manor, Brad (Harvard Medical School) ;
Pascual Leone, Álvaro (Harvard Medical School) ;
Universitat Autònoma de Barcelona
Over 55 million people worldwide are currently diagnosed with Alzheimer's disease (AD) and live with debilitating episodic memory deficits. Current pharmacological treatments have limited efficacy. Recently, transcranial alternating current stimulation (tACS) has shown memory improvement in AD by normalizing high-frequency neuronal activity. [...]
2023 - 10.3389/fnhum.2023.1168673
Frontiers in human neuroscience, Vol. 17 (june 2023)
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16.
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16 p, 2.2 MB |
Brain system segregation and pain catastrophizing in chronic pain progression
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Delgado-Gallén, Selma (Institut Germans Trias i Pujol. Institut Guttmann) ;
Soler, MD (Institut Germans Trias i Pujol. Institut Guttmann) ;
Cabello-Toscano, María del Rocío (Institut Germans Trias i Pujol. Institut Guttmann) ;
Abellaneda‑Pérez, Kilian (Institut Germans Trias i Pujol. Institut Guttmann) ;
Solana-Sánchez, Javier (Institut Germans Trias i Pujol. Institut Guttmann) ;
España-Irla, Goretti (Institut Germans Trias i Pujol. Institut Guttmann) ;
Roca-Ventura, Alba (Institut Germans Trias i Pujol. Institut Guttmann) ;
Bartrés-Faz, David (Institut Germans Trias i Pujol. Institut Guttmann) ;
Tormos, Josep M. (Institut Germans Trias i Pujol. Institut Guttmann) ;
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann) ;
Cattaneo, Gabriele (Institut Germans Trias i Pujol. Institut Guttmann) ;
Universitat Autònoma de Barcelona
Pain processing involves emotional and cognitive factors that can modify pain perception. Increasing evidence suggests that pain catastrophizing (PC) is implicated, through pain-related self-thoughts, in the maladaptive plastic changes related to the maintenance of chronic pain (CP). [...]
2023 - 10.3389/fnins.2023.1148176
Frontiers in Neuroscience, Vol. 17 (march 2023)
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17.
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19 p, 1.5 MB |
Neurofilaments contribution in clinic : state of the art
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Delaby, Constance (Institut d'Investigació Biomèdica Sant Pau) ;
Bousiges, Olivier (Laboratoire de biochimie et biologie moléculaire (LBBM)-Pôle de biologie Hôpital de Hautepierre-CHU de Strasbourg. CNRS. laboratoire ICube UMR 7357 et FMTS (Fédération de Médecine Translationnelle de Strasbourg). équipe IMIS) ;
Bouvier, Damien (Service de Biochimie et Génétique Moléculaire. CHU de Clermont-Ferrand) ;
Fillée, Catherine (Cliniques universitaires Saint-Luc UCLouvain. Service de Biochimie Médicale) ;
Fourier, Anthony (Biochimie et Biologie Moléculaire-LBMMS. Unité de diagnostic des pathologies dégénératives. Centre de Biologie et Pathologie Est. Groupement Hospitalier Est) ;
Mondésert, Etienne (Université de Montpellier. IRMB. INM. INSERM. CHU de Montpellier. Laboratoire Biochimie-Protéomique clinique) ;
Nezry, Nicolas (Univ. Lille. Inserm. CHU Lille. UMR-S-U1172. LiCEND. Lille Neuroscience Cognition. LabEx DISTALZ) ;
Omar, Souheil (Laboratoire de biologie médicale de l'Institut de Neurologie de Tunis) ;
Quadrio, Isabelle (Biochimie et Biologie Moléculaire-LBMMS. Unité de diagnostic des pathologies dégénératives. Centre de Biologie et Pathologie Est. Groupement Hospitalier Est) ;
Rucheton, Benoit (Laboratoire de Biologie. Institut Bergonié) ;
Schraen-Maschke, Susanna (Univ. Lille. Inserm. CHU Lille. UMR-S-U1172. LiCEND. Lille Neuroscience Cognition. LabEx DISTALZ) ;
van Pesch, Vincent (Cliniques universitaires Saint-Luc UCLouvain. Service de Neurologie) ;
Vicca, Stéphanie (Hôpital Necker-Enfants malades. Paris. Laboratoire de Biochimie générale. DMU BioPhyGen. AP-HP.Centre-Université de Paris) ;
Lehmann, Sylvain (Université de Montpellier. IRMB. INM. INSERM. CHU de Montpellier. Laboratoire Biochimie-Protéomique clinique) ;
Bedel, Aurelie (Service de Biochimie. CHU Pellegrin) ;
Universitat Autònoma de Barcelona
Neurological biomarkers are particularly valuable to clinicians as they can be used for diagnosis, prognosis, or response to treatment. This field of neurology has evolved considerably in recent years with the improvement of analytical methods, allowing the detection of biomarkers not only in cerebrospinal fluid (CSF) but also in less invasive fluids like blood. [...]
2022 - 10.3389/fnagi.2022.1034684
Frontiers in aging neuroscience, Vol. 14 (january 2022) , p. 1034684
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18.
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12 p, 1.4 MB |
Macular vessel density in the superficial plexus is not associated to cerebrospinal fluid core biomarkers for Alzheimer's disease in individuals with mild cognitive impairment : The NORFACE cohort
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Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
García-Sánchez, Ainhoa (Universitat Internacional de Catalunya) ;
Alarcón-Martín, Emilio (Universitat Internacional de Catalunya) ;
Martínez, Joan (Universitat Internacional de Catalunya) ;
Castilla Marti, Miguel (Clínica Oftalmológica Dr. Castilla) ;
Castilla-Martí, Luis (Universitat Autònoma de Barcelona. Departament de Cirurgia) ;
Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Montrreal, Laura (Universitat Internacional de Catalunya) ;
De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
García-González, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Puerta, Raquel (Universitat Internacional de Catalunya) ;
Olivé, Clàudia (Universitat Internacional de Catalunya) ;
Cano, Amanda (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Hernández, Isabel (Universitat Internacional de Catalunya) ;
Rosende-Roca, Maitée (Universitat Internacional de Catalunya) ;
Vargas, Liliana (Universitat Internacional de Catalunya) ;
Tartari, Juan Pablo (Universitat Internacional de Catalunya) ;
Esteban-De Antonio, Ester (Universitat Internacional de Catalunya) ;
Bojaryn, Urszula (Universitat Internacional de Catalunya) ;
Ricciardi, Mario (Universitat Internacional de Catalunya) ;
Ariton, Diana María (Universitat Internacional de Catalunya) ;
Pytel, Vanesa (Universitat Internacional de Catalunya) ;
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ortega, Gemma (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Espinosa, Ana (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pérez-Cordón, Alba (Universitat Internacional de Catalunya) ;
Sanabria, Ángela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Muñoz, Nathalia (Universitat Internacional de Catalunya) ;
Lleonart, Núria (Universitat Internacional de Catalunya) ;
Aguilera, Núria (Universitat Internacional de Catalunya) ;
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Optical coherence tomography angiography (OCT-A) is a novel method in the dementia field that allows the detection of retinal vascular changes. The comparison of OCT-A measures with established Alzheimer's disease (AD)-related biomarkers is essential to validate the former as a marker of cerebrovascular impairment in the AD continuum. [...]
2023 - 10.3389/fnins.2023.1076177
Frontiers in Neuroscience, Vol. 17 (february 2023)
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19.
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11 p, 2.4 MB |
The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment
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Torres-Simon, Lucia (Universidad Complutense de Madrid. Departamento de Psicología Experimental) ;
Cuesta, Pablo (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
del Cerro-Leon, Alberto (Universidad Complutense de Madrid. Departamento de Psicología Experimental) ;
Chino, Brenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Orozco, Lucia H. (Universidad Complutense de Madrid. Centro de Neurociencia Cognitiva y Computacional) ;
Marsh, Elisabeth B. (Department of Neurology, The Johns Hopkins School of Medicine) ;
Gil Gregorio, Pedro (Hospital Universitario Clínico San Carlos (Madrid)) ;
Maestu, Fernando (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Cerebrovascular disease is responsible for up to 20% of cases of dementia worldwide, but also it is a major comorbid contributor to the progression of other neurodegenerative diseases, like Alzheimer's disease. [...]
2023 - 10.3389/fnhum.2023.1068216
Frontiers in human neuroscience, Vol. 17 (february 2023)
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20.
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12 p, 3.0 MB |
Computational assessment of the impact of Cu(II) and Al(III) on β-amyloid fibrils : Binding sites, structural stability, and possible physiological implications
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Roldán-Martín, Lorena (Universitat Autònoma de Barcelona. Departament de Química) ;
Sodupe Roure, Mariona (Universitat Autònoma de Barcelona. Departament de Química) ;
Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química)
One of Alzheimer's disease major hallmarks is the aggregation of β-amyloid peptide, a process in which metal ions play an important role. In the present work, an integrative computational study has been performed to identify the metal-binding regions and determine the conformational impact of Cu(II) and Al(III) ion binding to the β-amyloid (Aβ) fibrillary structure. [...]
2023 - 10.3389/fnins.2023.1110311
Frontiers in Neuroscience, Vol. 17 (February 2023) , art. 1110311
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