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14 p, 5.4 MB |
Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant
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Avila-Nieto, Carlos (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vergara-Alert, Júlia (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Amengual-Rigo, Pep (Barcelona Supercomputing Center) ;
Ainsua-Enrich, Erola (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brustolin, Marco (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Rodríguez de la Concepción, María Luisa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pedreño-López, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodon, Jordi (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pradenas, Edwards (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marfil, Sílvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pérez, Mònica (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Roca, Núria (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Tarrés-Freixas, Ferran (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carabelli, Julieta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cantero, Guillermo (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Pons-Grífols, Anna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rovirosa, Carla (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Aguilar-Gurrieri, Carmen (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ortiz, Raquel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Barajas Vélez, Ana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Trinité, Benjamin (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lepore, Rosalba (Barcelona Supercomputing Center) ;
Muñoz-Basagoiti, Jordana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Perez-Zsolt, Daniel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Valencia, Alfonso (Institució Catalana de Recerca i Estudis Avançats) ;
Blanco, Julià (Universitat de Vic - Universitat Central de Catalunya) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Guallar, Victor (Institució Catalana de Recerca i Estudis Avançats) ;
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Most COVID-19 vaccines are based on the SARS-CoV-2 Spike glycoprotein (S) or their subunits. However, S shows some structural instability that limits its immunogenicity and production, hampering the development of recombinant S-based vaccines. [...]
2023 -  10.3389/fimmu.2023.1291972
Frontiers in immunology, Vol. 14 (december 2023)
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12.
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7 p, 979.4 KB |
pCRP-mCRP dissociation mechanisms as potential targets for the development of small-molecule anti-inflammatory chemotherapeutics
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Caprio, Vittorio (Manchester Metropolitan University) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Di Napoli, Mario (Ospedale San Camillo de Lellis) ;
Fang, Wen-Hui (Manchester Metropolitan University) ;
Ferris, Glenn R. (Manchester Metropolitan University) ;
Guo, Baoqiang (Weifang Medical University) ;
Iemma, Rocco S. (Manchester Metropolitan University) ;
Liu, Donghui (University of Medicine and Pharmacy) ;
Zeinolabediny, Yasmin (University of Medicine and Pharmacy) ;
Slevin, Mark (University of Medicine and Pharmacy) ;
Universitat Autònoma de Barcelona
Circulating C-reactive protein (CRP) is a key acute-phase protein and one of the main clinical biomarkers for inflammation and infection. CRP is an important upstream mediator of inflammation and is associated with the onset of a number of important disease states including cardiovascular disease and neurodegenerative disorders such as Alzheimer's disease. [...]
2018 - 10.3389/fimmu.2018.01089
Frontiers in immunology, Vol. 9 Núm. MAY (28 2018) , p. 1089
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13.
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12 p, 5.4 MB |
Impaired antigen-specific B-cell responses after Influenza vaccination in kidney transplant recipients receiving co-stimulation blockade with Belatacept
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Pernin, Vincent (University Hospital of Montpellier (França)) ;
Meneghini, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torija Recasens, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jouve, Thomas (Grenoble University Hospital) ;
Del Bello, Arnaud (Universidad de Valladolid) ;
Sanz-Muñoz, Iván (Universidad de Valladolid) ;
Eiros, Jose Maria (Universidad de Valladolid) ;
Donadeu, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Puig-Polo, Carol (Hospital Universitari de Bellvitge) ;
Morandeira Rego, Francisco (Hospital Universitari de Bellvitge) ;
Navarro Velázquez, Sergio (Hospital Universitari de Bellvitge) ;
Masuet-Aumatell, Cristina (Hospital Universitari de Bellvitge) ;
Favà, Alexandre (Hospital Universitari de Bellvitge) ;
LeQuintrec, Moglie (University Hospital of Montpellier (França)) ;
Kamar, Nassim (Grenoble University Hospital) ;
Crespo, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bestard, Oriol (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Emerging data suggest that costimulation blockade with belatacept effectively controls humoral alloimmune responses. However, whether this effect may be deleterious for protective anti-infectious immunity remains poorly understood. [...]
2022 - 10.3389/fimmu.2022.918887
Frontiers in immunology, Vol. 13 (july 2022)
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8 p, 3.0 MB |
Association of Serum Ferritin Levels Before Start of Conditioning With Mortality After alloSCT - A Prospective, Non-interventional Study of the EBMT Transplant Complications Working Party
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Penack, Olaf (Charité - Universitätsmedizin Berlin) ;
Peczynski, Christophe (EBMT Statistical Unit) ;
van der Werf, Steffie (EBMT Data Office) ;
Finke, Jürgen (University of Freiburg) ;
Ganser, Arnold (Hannover Medical School) ;
Schoemans, Helene (University Hospitals Leuven (Bèlgica)) ;
Pavlu, Jiri (Imperial College London) ;
Niittyvuopio, Riitta (HUCH Comprehensive Cancer Center) ;
Schroyens, W.ilfried (University Hospital Antwerp (Bèlgica)) ;
Kaynar, Leylagül (Erciyes University) ;
Blau, Igor W. (Department of Hematology. Oncology. and Tumor Immunology) ;
van der Velden, Walter J.F.M. (Radboud University) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Cortelezzi, Agostini (University of Milan) ;
Wulf, Gerald (Universitätsklinikum Göttingen) ;
Turlure, Pascal (CHRU Limoges) ;
Rovira Argelagués, Montserrat (Hospital Clínic i Provincial de Barcelona) ;
Ozkurt, Zubeydenur (Gazi University) ;
Pascual-Cascon, Maria J. (Hospital Regional Universitario de Málaga) ;
Moreira, Maria C. (Instituto National do Cancer) ;
Clausen, Johannes (Ordensklinikum Linz Elisabethinen) ;
Greinix, Hildegard (Medical University of Graz) ;
Duarte, Rafael F. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Basak, Grzegorz (Medical University of Warsaw) ;
Universitat Autònoma de Barcelona
Elevated serum ferritin levels occur due to iron overload or during inflammation and macrophage activation. A correlation of high serum ferritin levels with increased mortality after alloSCT has been suggested by several retrospective analyses as well as by two smaller prospective studies. [...]
2020 - 10.3389/fimmu.2020.00586
Frontiers in immunology, Vol. 11 (15 2020) , p. 586
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13 p, 10.6 MB |
Exploiting endocytosis for transfection of mRNA for cytoplasmatic delivery using cationic gold nanoparticles
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Gustà, Muriel F. (Institut Català de Nanociència i Nanotecnologia) ;
Edel, Michael J (Universitat Autònoma de Barcelona) ;
Salazar Montoya, Vivian Angélica (Institut Català de Nanociència i Nanotecnologia) ;
Alvarez-Palomo, Belén (Banc de Sang i Teixits) ;
Juan, Manel (Hospital Clínic i Provincial de Barcelona) ;
Broggini, Massimo (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri) ;
Damia, Giovanna (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri) ;
Bigini, Paolo (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri) ;
Corbelli, Alessandro (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri) ;
Fiordaliso, Fabio (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri) ;
Barbul, Alexander (Tel Aviv University) ;
Korenstein, Rafi (Tel Aviv University) ;
Bastús, Neus G (Institut Català de Nanociència i Nanotecnologia) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Gene therapy holds promise to cure various diseases at the fundamental level. For that, efficient carriers are needed for successful gene delivery. Synthetic 'non-viral' vectors, as cationic polymers, are quickly gaining popularity as efficient vectors for transmitting genes. [...]
2023 - 10.3389/fimmu.2023.1128582
Frontiers in immunology, Vol. 14 (May 2023) , art. 1128582
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12 p, 3.7 MB |
Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors
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Kilpeläinen, Athina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Jiménez-Moyano, Esther (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanch-Lombarte, Oscar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Peña, Ruth (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Quirant, Bibiana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Caballero, Raúl (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Chamorro, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco Guillermo, Ignacio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mateu, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
The role of T cells in the control of SARS-CoV-2 infection has been underestimated in favor of neutralizing antibodies. However, cellular immunity is essential for long-term viral control and protection from disease severity. [...]
2022 - 10.3389/fimmu.2022.815041
Frontiers in immunology, Vol. 13 (may 2022)
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18.
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11 p, 918.0 KB |
Brief Research Report : Anti-SARS-CoV-2 Immunity in Long Lasting Responders to Cancer Immunotherapy Through mRNA-Based COVID-19 Vaccination
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Sisteré-Oró, Marta (Universitat Pompeu Fabra) ;
Wortmann, Diana D. J. (Universitat Pompeu Fabra) ;
Andrade, Naína (Universitat Pompeu Fabra) ;
Aguilar-Hernández, Andrés (Hospital Quiron-Dexeus Barcelona) ;
Mayo de las Casas, Clara (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Casabal, Florencia Garcia (Hospital Quiron-Dexeus Barcelona) ;
Torres, Susana (Hospital Quiron-Dexeus Barcelona) ;
Bona Salinas, Eduardo (Hospital Quiron-Dexeus Barcelona) ;
Raventos Soler, Laura (Hospital Quiron-Dexeus Barcelona) ;
Arcas, Andrea (Hospital Quiron-Dexeus Barcelona) ;
Esparre, Carlos (Hospital Quiron-Dexeus Barcelona) ;
Garcia, Beatriz (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Valarezo, Joselyn (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Güerri-Fernández, Robert (Hospital del Mar (Barcelona, Catalunya)) ;
Gonzalez-Cao, Maria (Hospital Quiron-Dexeus Barcelona) ;
Meyerhans, Andreas (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Cancer patients (CPs) have been identified as particularly vulnerable to SARS-CoV-2 infection, and therefore are a priority group for receiving COVID-19 vaccination. From the patients with advanced solid tumors, about 20% respond very efficiently to immunotherapy with anti-PD1/PD-L1 antibodies and achieve long lasting cancer responses. [...]
2022 - 10.3389/fimmu.2022.908108
Frontiers in immunology, Vol. 13 (july 2022)
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