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1.
17 p, 2.5 MB Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles / Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Drobniewski, Francis (Imperial College) ; Kontsevaya, Irina (N.V. Postnikov Samara Region Clinical Tuberculosis Dispensary) ; Arias, Lilibeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Monguió-Tortajada, Marta (Universitat Autònoma de Barcelona) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ong, Ruo-Yan (University of Dundee) ; (Marina) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Dupont, Maeva (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ; Chojnacki, Jakub (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Cardona, Paula (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Neyrolles, Olivier (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ; Lugo-Villarino, Geanncarlo (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ; Vérollet, Christel (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ; Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Furrer, Hansjakob (University of Bern) ; Günthard, Huldrych F. (University of Zurich) ; Crocker, Paul R. (University of Dundee) ; Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Fellay, Jacques (Lausanne University Hospital) ; McLaren, Paul J. (University of Manitoba) ; Telenti, Amalio (The Scripps Research Institute) ; Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non-functional variant in SIGLEC1, which encodes the myeloid-cell receptor Siglec-1/CD169 implicated in HIV-1 cell-to-cell transmission. [...]
2021 - 10.1002/jev2.12046
Journal of extracellular vesicles, Vol. 10 (january 2021)  
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2.
11 p, 354.4 KB Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART : a multicohort European case-control study using centralized ultrasensitive 454 pyrosequencing / Cozzi-Lepri, Alessandro (University College London) ; Noguera-Julian, Marc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Di Giallonardo, Francesca (University Hospital Zurich (Suïssa)) ; Schuurman, Rob (Department of Virology. University Medical Centre, Utrecht) ; Däumer, Martin (Institut für Immunologie und Genetik, Kaiserslautern, Germany) ; Aitken, Sue (Department of Virology. University Medical Centre, Utrecht) ; Ceccherini-Silberstein, Francesca (Department of Experimental Medicine and Surgery, University of Rome Tor Vergata) ; D'Arminio Monforte, Antonella (Clinic of Infectious Diseases, 'San Paolo' Hospital) ; Geretti, Anna Maria (Institute of Infection & Global Health, University of Liverpool) ; Booth, Clare L. (Department of Virology, Royal Free London NHS Foundation Trust) ; Kaiser, Rolf (Institute of Virology, University of Cologne) ; Michalik, Claudia (Competence Network for HIV/AIDS, Bochum, Germany) ; Jansen, Klaus (Competence Network for HIV/AIDS, Bochum, Germany) ; Masquelier, Bernard (Université Bordeaux 2) ; Bellecave, Pantxika (Université Bordeaux 2) ; Kouyos, Roger D. (University Hospital Zurich (Suïssa)) ; Castro, Erika (Centre Hospitalier Universitaire Vaudois (Lausanne, Suïssa). Service of Community Psychiatry) ; Furrer, Hansjakob (Bern University Hospital) ; Schultze, Anna (University College London) ; Günthard, Huldrych F. (University Hospital Zurich (Suïssa)) ; Brun-Vezinet, Francoise (Department of Virology, Bichat University Hospital, Paris) ; Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Metzner, Karin J. (University Hospital Zurich (Suïssa)) ; CHAIN Minority HIV-1 Variants Working Group
It is still debated if pre-existing minority drug-resistant HIV-1 variants (MVs) affect the virological outcomes of first-line NNRTI-containing ART. This Europe-wide case-control study included ART-naive subjects infected with drug-susceptible HIV-1 as revealed by population sequencing, who achieved virological suppression on first-line ART including one NNRTI. [...]
2014 - 10.1093/jac/dku426
Journal of antimicrobial chemotherapy, Vol. 70 (october 2014) , p. 930-940  
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3.
7 p, 617.5 KB Identification of Siglec-1 null individuals infected with HIV-1 / Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; McLaren, Paul J. (National HIV and Retrovirology Laboratory (Winnipeg, Canadà)) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martin, Maureen P. (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ; Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rotger, Margalida (University of Lausanne (Suïssa)) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Wolinsky, Steven M. (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ; Penugonda, Sudhir (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ; Günthard, Huldrych F. (University Hospital Zurich (Suïssa)) ; Fellay, Jacques (École Polytechnique Fédérale de Lausanne (Suïssa)) ; Carrington, Mary (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ; Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Telenti, Amalio (J. Craig Venter Institute (La Jolla, Estats Units d'Amèrica))
Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of SIGLEC1 in natura, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) that is found in ∼1% of healthy people. [...]
2016 - 10.1038/ncomms12412
Nature communications, Vol. 7 Núm. 12412 (August 2016)  
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