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5 p, 501.6 KB |
CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
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van der Ende, Emma L (Alzheimer Center Rotterdam and Dept. of Neurology. Erasmus University Medical Center) ;
Morenas-Rodriguez, Estrella (Ludwig-Maximilians-Universität München) ;
McMillan, Corey T. (Penn Frontotemporal Degeneration Center. University of Pennsylvania Perelman School of Medicine) ;
Grossman, Murray (Penn Frontotemporal Degeneration Center. University of Pennsylvania Perelman School of Medicine) ;
Irwin, David J. (Penn Frontotemporal Degeneration Center. University of Pennsylvania Perelman School of Medicine) ;
Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Graff, Caroline (Unit of Hereditary Dementia. Theme Aging. Karolinska University Hospital-Solna) ;
Vandenberghe, Rik (Laboratory for Cognitive Neurology. Department of Neurosciences. Leuven Brain Institute) ;
Pijnenburg, Yolande (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Vrije Universiteit Amsterdam) ;
Laforce, Robert Jr (Clinique Interdisciplinaire de Mémoire du CHU de Québec. département des Sciences Neurologiques. Université Laval) ;
Le Ber, Isabelle (Sorbonne Université. Paris Brain Institute. Institut du Cerveau. ICM. Inserm U1127. CNRS UMR 7225. APHP. Hôpital Pitié-Salpêtrière) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Haass, Christian (Munich Cluster for Systems Neurology (SyNergy)) ;
Suárez-Calvet, Marc (German Center for Neurodegenerative Diseases (DZNE) Munich) ;
van Swieten, John Cornelis (Alzheimer Center Rotterdam and Dept. of Neurology. Erasmus University Medical Center) ;
Seelaar, Harro (Alzheimer Center Rotterdam and Dept. of Neurology. Erasmus University Medical Center)
Excessive microglial activation might be a central pathological process in GRN-related frontotemporal dementia (FTD-GRN). We measured soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is shed from disease-associated microglia following cleavage of TREM2, in cerebrospinal fluid of 34 presymptomatic and 35 symptomatic GRN mutation carriers, 6 presymptomatic and 32 symptomatic C9orf72 mutation carriers and 67 healthy noncarriers by ELISA. [...]
2021 -  10.1016/j.neurobiolaging.2021.02.024
Neurobiology of Aging, Vol. 103 (july 2021) , p. 158.e1-158.e5
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14 p, 1.2 MB |
Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
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Suárez Calvet, Marc (Ludwig-Maximilians-Universität München) ;
Morenas-Rodríguez, Estrella (Institut d'Investigació Biomèdica Sant Pau) ;
Kleinberger, Gernot (Ludwig-Maximilians-Universität München) ;
Schlepckow, Kai (German Center for Neurodegenerative Diseases (DZNE) Munich) ;
Araque Caballero, Miguel Ángel (Ludwig-Maximilians-Universität München) ;
Franzmeier, Nicolai (Ludwig-Maximilians-Universität München) ;
Capell, Anja (Ludwig-Maximilians-Universität München) ;
Fellerer, Katrin (Ludwig-Maximilians-Universität München) ;
Nuscher, Brigitte (Ludwig-Maximilians-Universität München) ;
Eren, Erden (Ludwig-Maximilians-Universität München) ;
Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) Munich) ;
Deming, Yuetiva (Washington University School of Medicine) ;
Piccio, Laura (Washington University School of Medicine) ;
Karch, Celeste M. (Washington University School of Medicine) ;
Cruchaga, Carlos (Washington University School of Medicine) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Trojanowski, John Q.. (University of Pennsylvania) ;
Weiner, Michael (University of California at San Francisco) ;
Ewers, Michael (Ludwig-Maximilians-Universität München) ;
Haass, Christian (Ludwig-Maximilians-Universität München) ;
Universitat Autònoma de Barcelona
TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-onset Alzheimer's disease (AD). [...]
2019 - 10.1186/s13024-018-0301-5
Molecular neurodegeneration, Vol. 14 (january 2019)
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10 p, 2.2 MB |
Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer's disease
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Morenas-Rodríguez, Estrella (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel. (Institut d'Investigació Biomèdica Sant Pau) ;
Suárez-Calvet, M. (German Center for Neurodegenerative Diseases (DZNE) Munich) ;
Muñoz-Llahuna, L. (Institut d'Investigació Biomèdica Sant Pau) ;
Vilaplana, Eduard (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Subirana, Andrea (Institut d'Investigació Biomèdica Sant Pau) ;
Querol-Vilaseca, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ;
Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Ribosa-Nogué, Roser (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Haass, Christian (Munich Cluster for Systems Neurology (SyNergy)) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
The role of innate immunity in dementia with Lewy bodies (DLB) has been little studied. We investigated the levels in cerebrospinal fluid (CSF) of glial proteins YKL-40, soluble TREM2 (sTREM2) and progranulin in DLB and their relationship with Alzheimer's disease (AD) biomarkers. [...]
2019 - 10.1038/s41598-019-44173-8
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 7803
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21 p, 965.2 KB |
CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
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Suárez-Calvet, Marc (Ludwig-Maximilians-Universität München) ;
Capell, Anja (Ludwig-Maximilians-Universität München) ;
Araque Caballero, Miguel Ángel (Ludwig-Maximilians-Universität München) ;
Morenas-Rodríguez, Estrella (Universitat Autònoma de Barcelona) ;
Fellerer, Katrin (Ludwig-Maximilians-Universität München) ;
Franzmeier, Nicolai (Ludwig-Maximilians-Universität München) ;
Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy)) ;
Eren, Erden (Dokuz Eylul University, Turkey) ;
Deming, Yuetiva (Washington University School of Medicine) ;
Piccio, Laura (Washington University School of Medicine) ;
Karch, Celeste M. (Washington University School of Medicine) ;
Cruchaga, Carlos (Washington University School of Medicine) ;
Paumier, Katrina (Washington University School of Medicine) ;
Bateman, Randall J. (Washington University School of Medicine) ;
Fagan, Anne M. (Washington University School of Medicine) ;
Morris, John C. (Washington University School of Medicine) ;
Levin, Johannes (Ludwig-Maximilians-Universität München) ;
Danek, Adrian (Ludwig-Maximilians-Universität München) ;
Jucker, Mathias (University of Tübingen) ;
Masters, Colin L. (University of Melbourne) ;
Rossor, Martin N. (UCL Institute of Neurology (Regne Unit)) ;
Ringman, John M. (University of Southern California) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Trojanowski, John Q.. (University of Pennsylvania) ;
Weiner, Michael (University of California at San Francisco) ;
Ewers, Michael (Ludwig-Maximilians-Universität München) ;
Haass, Christian (Munich Cluster for Systems Neurology (SyNergy))
Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked whether expression is changed in a disease severity-specific manner in . [...]
2018 - 10.15252/emmm.201809712
EMBO Molecular Medicine, Vol. 10 (november 2018)
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10 p, 838.9 KB |
The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
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Gispert, Juan Domingo (Universitat Pompeu Fabra) ;
Monté, Gemma C. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Suárez-Calvet, Marc (German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany) ;
Falcon, Carles (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Tucholka, Alan (Barcelonaβeta Brain Research Center (BBRC)) ;
Rojas, Santiago (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Llado Plarrumani, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ;
Haass, Christian (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ;
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Among other metabolic functions, the apolipoprotein E (APOE) plays a crucial role in neuroinflammation. We aimed at assessing whether APOE ε4 modulates levels of glial cerebrospinal fluid (CSF) biomarkers and their structural cerebral correlates along the continuum of Alzheimer's disease (AD). [...]
2016 - 10.1016/j.dadm.2016.12.002
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 6 (december 2016) , p. 50-59
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11 p, 519.1 KB |
2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers
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Suárez-Calvet, Marc (German Center for Neurodegenerative Diseases (DZNE) Munich) ;
Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy)) ;
Araque Caballero, Miguel Ángel (Ludwig-Maximilians-University Munich) ;
Brendel, Matthias (Ludwig-Maximilians-University Munich) ;
Rominger, Axel (Ludwig-Maximilians-University Munich) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Gispert, Juan Domingo (Institut d'Investigació Biomèdica Sant Pau) ;
Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Antonell, Anna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Brosseron, Frederic (German Center for Neurodegenerative Diseases (DZNE)) ;
Traschütz, Andreas (Universitätsklinikum Bonn) ;
Heneka, Michael T. (Universitätsklinikum Bonn) ;
Struyfs, Hanne (University Hospital Antwerp (Bèlgica)) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Sleegers, Kristel (University of Antwerp. Institute Born-Bunge) ;
Van Broeckhoven, Christine (University of Antwerp. Institute Born-Bunge) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Nellgård, Bengt (Gothenburg University. Sahlgrenska Academy. Institute of Clinical Sciences) ;
Blennow, Kaj (The Sahlgrenska Academy at the University of Gothenburg. Institute of Neuroscience and Physiology) ;
Crispin, Alexander (Institute of Medical Informatics, Biometry, and Epidemiology) ;
Ewers, Michael (Ludwig-Maximilians-University Munich) ;
Haass, Christian (BioMedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich) ;
Universitat Autònoma de Barcelona
2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of 2 are associated with increased risk of Alzheimer's disease (). 2 is a type-1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as a soluble variant (2), which can be measured in the cerebrospinal fluid (). [...]
2016 - 10.15252/emmm.201506123
EMBO Molecular Medicine, Vol. 8 (march 2016) , p. 466-476
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