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A multicentre validation study of the diagnostic value of plasma neurofilament light / Ashton, Nicholas J. (NIHR Biomedical Research Centre for Mental Health (Londres, Regne Unit)) ; Janelidze, Shorena (Clinical Memory Research Unit. Department of Clinical Sciences Malmö. Lund University) ; Al Khleifat, Ahmad (Department of Basic and Clinical Neuroscience. Maurice Wohl Clinical Neuroscience Institute. King's College London) ; Leuzy, Antoine (Clinical Memory Research Unit. Department of Clinical Sciences Malmö. Lund University) ; van der Ende, Emma L. (Alzheimer Center Rotterdam and Dept. of Neurology. Erasmus University Medical Center) ; Karikari, Thomas K (Department of Psychiatry and Neurochemistry. Institute of Neuroscience & Physiology. The Sahlgrenska Academy at the University of Gothenburg) ; Benedet, AndreaL. (Montreal Neurological Institute) ; Pascoal, Tharick A. (Montreal Neurological Institute) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Parnetti, Lucilla (Laboratory of Clinical Neurochemistry. Neurology Clinic. University of Perugia) ; Galimberti, Daniela (University of Milan) ; Bonanni, Laura (Department of Neuroscience. Imaging and Clinical Sciences. University G.d'Annunzio of Chieti-Pescara) ; Pilotto, Andrea (Parkinson's Disease Rehabilitation Centre. FERB ONLUS) ; Padovani, Alessandro (Neurology Unit. Department of Clinical and Experimental Sciences. University of Brescia) ; Lycke, Jan (Sahlgrenska University Hospital (Suècia)) ; Novakova, Lenka (Sahlgrenska University Hospital (Suècia)) ; Axelsson, Markus (Sahlgrenska University Hospital (Suècia)) ; Velayudhan, Latha (Department of Health Sciences. University of Leicester) ; Rabinovici, Gil D. (Department of Radiology & Biomedical Imaging. University of California) ; Miller, Bruce L. (University of California San Francisco. Memory and Aging Center) ; Pariante, Carmine M (Stress. Psychiatry and Immunology Lab & Perinatal Psychiatry. Maurice Wohl Clinical Neuroscience Institute. King's College London) ; Nikkheslat, Naghmeh (King's College London (Regne Unit)) ; Resnick, Susan M. (Brain Aging and Behavior Section. Laboratory of Behavioral Neuroscience. National Institute on Aging. National Institutes of Health) ; Thambisetty, Madhav (Clinical and Translational Neuroscience Section. Laboratory of Behavioral Neuroscience. National Institute on Aging. National Institutes of Health) ; Schöll, Michael (Department of Neurodegenerative Disease. Queen Square Institute of Neurology. University College London) ; Fernández-Eulate, Gorka (Department of Neurology. Donostia University Hospital. Osakidetza) ; Gil-Bea, Francisco J. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; López de Munain, Adolfo (Universidad del País Vasco. Departamento de Neurociencias) ; Al-Chalabi, Ammar (King's College Hospital NHS Foundation Trust) ; Rosa-Neto, Pedro (Montreal Neurological Institute) ; Strydom, Andre (London Down Syndrome Consortium (LonDowns)) ; Svenningsson, Per (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ; Stomrud, Erik (Skåne University Hospital (Suècia)) ; Santillo, Alexander (Lund University. Department of Clinical Sciences Malmö) ; Aarsland, Dag (Stavanger University Hospital) ; van Swieten, John C. (Erasmus University Medical Center) ; Palmqvist, Sebastian (Lund University. Skåne University Hospital) ; Zetterberg, Henrik (University College London. UK Dementia Research Institute) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Hye, Abdul (Stavanger University Hospital) ; Hansson, Oskar (Skåne University Hospital (Suècia))
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n = 805) and the Swedish BioFINDER study (n = 1,464). [...]
2021 - DOI (Digital Object Identifier)

10.1038/s41467-021-23620-z
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 3400

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21	Hansson, P.

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