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8 p, 3.1 MB |
Lkb1 Loss Promotes Tumor Progression of BRAF V600E -Induced Lung Adenomas
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González-Sánchez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martín-Caballero, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Flores, Juana María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Cortés, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Marés, Roso (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Barbacid, Mariano (Centro Nacional de Investigaciones Oncológicas) ;
Recio Conde, Juan Ángel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Aberrant activation of MAP kinase signaling pathway and loss of tumor suppressor LKB1 have been implicated in lung cancer development and progression. Although oncogenic KRAS mutations are frequent, BRAF mutations (BRAF V600E) are found in 3% of human non-small cell lung cancers. [...]
2013 -  10.1371/journal.pone.0066933
PloS one, Vol. 8 (june 2013)
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13.
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6 p, 348.3 KB |
Fluorescence In Situ Hybridization and Immunohistochemistry as Diagnostic Methods for ALK Positive Non-Small Cell Lung Cancer Patients
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Martinez, Pablo (Vall d'Hebron Institut d'Oncologia) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cedrés, Susana (Vall d'Hebron Institut d'Oncologia) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Marti, Alex (Vall d'Hebron Institut d'Oncologia) ;
Tallada, Natalia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Murtra-Garrell, Nuria (Vall d'Hebron Institut d'Oncologia) ;
Navarro, Alejandro (Vall d'Hebron Institut d'Oncologia) ;
Rodriguez-Freixinos, Victor (Vall d'Hebron Institut d'Oncologia) ;
Canela, Mercedes (Vall d'Hebron Institut d'Oncologia) ;
Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Felip, Enriqueta (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
Anaplastic Lymphoma Kinase (ALK) positivity represents a novel molecular target in a subset of Non-Small Cell Lung Cancers (NSCLC). We explore Fluorescence in situ Hybridization (FISH) and Immunohistochemistry (IHC) as diagnostic methods for ALK positive patients and to describe its prevalence and outcomes in a population of NSCLC patients. [...]
2013 - 10.1371/journal.pone.0052261
PloS one, Vol. 8 (january 2013)
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14.
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10 p, 2.5 MB |
Myo5b knockout mice as a model of microvillus inclusion disease
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Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Overeem, Arend W. (University Medical Center Groningen) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Schwartz, Simo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
van Ijzendoorn, Sven C. D. (University Medical Center Groningen) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Inherited MYO5B mutations have recently been associated with microvillus inclusion disease (MVID), an autosomal recessive syndrome characterized by intractable, life-threatening, watery diarrhea appearing shortly after birth. [...]
2015 - 10.1038/srep12312
Scientific reports, Vol. 5 (07 2015)
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15.
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22 p, 4.8 MB |
Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T : A Rationale for Novel Therapeutic Approaches
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Martínez, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sesé, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Robichaud, Nathaniel (McGill University) ;
Sonenberg, Nahum (McGill University) ;
Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Phosphorylation of the eukaryotic translation initiation factor eIF4E is associated with malignant progression and poor cancer prognosis. Accordingly, here we have analyzed the association between eIF4E phosphorylation and cellular resistance to oxidative stress, starvation, and DNA-damaging agents in vitro. [...]
2015 - 10.1371/journal.pone.0123352
PloS one, Vol. 10 (april 2015)
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16.
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12 p, 2.3 MB |
Loss of the EPH receptor B6 contributes to colorectal cancer metastasis
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Mateo-Lozano, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mazzolini, Rocco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andretta, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández Caparrós, Yolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
del Llano, Edgar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Suárez-López, Lucía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jimenez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nuñez, Yaiza (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Afonso, Elsa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cacci, Karina (Hospital Universitari Vall d'Hebron) ;
Hernández-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
Mariadason, John M. (La Trobe University) ;
Schwartz, Simo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Matsui, Toshimitsu (Kobe University Graduate School of Medicine) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Although deregulation of EPHB signaling has been shown to be an important step in colorectal tumorigenesis, the role of EPHB6 in this process has not been investigated. We found here that manipulation of EPHB6 levels in colon cancer cell lines has no effect on their motility and growth on a solid substrate, soft agar or in a xenograft mouse model. [...]
2017 - 10.1038/srep43702
Scientific reports, Vol. 7 (03 2017)
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17.
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14 p, 4.2 MB |
STK11 (LKB1) missense somatic mutant isoforms promote tumor growth, motility and inflammation
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Granado-Martínez, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Ortega, Sara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González-Sánchez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
McGrail, Kimberley (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Selgas, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Grueso, Judit (Vall d'Hebron Institut d'Oncologia) ;
Gil, Rosa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Naldaiz-Gastesi, Neia (Present Address: Biodonostia, Neurosciences Area, Group of Neuromuscular Diseases) ;
Rhodes, Ana C. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Ferrer, Berta (Hospital Universitari Vall d'Hebron) ;
Canals, Francesc (Vall d'Hebron Institut d'Oncologia) ;
Villanueva, Josep (Vall d'Hebron Institut d'Oncologia) ;
Méndez Fernández, Olga (Vall d'Hebron Institut d'Oncologia) ;
Espinosa-Gil, Sergio (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Muñoz Couselo, Eva (Vall d'Hebron Institut d'Oncologia) ;
García-Patos Briones, Vicente (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Recio Conde, Juan Ángel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Elucidating the contribution of somatic mutations to cancer is essential for personalized medicine. STK11 (LKB1) appears to be inactivated in human cancer. However, somatic missense mutations also occur, and the role/s of these alterations to this disease remain unknown. [...]
2020 - 10.1038/s42003-020-1092-0
Communications Biology, Vol. 3 (july 2020)
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18.
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255 p, 9.2 MB |
Educación Superior y Pandemia : Aprendizajes y buenas prácticas en Iberoamérica
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Gairín Sallán, Joaquín, coord. (Universitat Autònoma de Barcelona) ;
Muñoz Moreno, José Luis, 1980- coord. (Universitat Autònoma de Barcelona) ;
Aguilar Chávez, Nohemy Scarleth ;
Alburquerque Moreira, Ana Maria de ;
Alcántara Zapata, Elsa ;
Amarilla Gaette, María Luján ;
Arce González, Consuelo ;
Assis de Miranda, Nonato ;
Benavides Meneses, Matías ;
Bizelli, José Luís ;
Capocasale, Alejandra ;
Castillo G., Carolina ;
Contreras Chacón, Azael Eduardo ;
Corea Tórrez, Norma Cándida ;
Correa, Gladys ;
Fernandes Costa, Ana Sheila ;
Jerónimo, Miguel ;
González Rubio, Janeth ;
Guerrero Rodríguez, Lilia Esther ;
Hernández Sánchez, Isaías Javier ;
Jacobina Aires, Carmenisia ;
Medrano Rodríguez, Hernán ;
Lopes Reis, Márcia ;
Lorena Reyes, Carmen ;
Marenco, Paola ;
Molina Yuncosa, Nuby ;
Nossar, Karina ;
Palmeros y Avila, Guadalupe ;
Pinheiro, Fernanda Paula ;
Questa-Torterolo, Mariela ;
Ramón González, Victor ;
Román Medina, Luciano ;
Sajevicius, Dora ;
Santacruz Zárate, Venialdo ;
Soligo, Marina ;
Soria-Valencia, Edith ;
Tafur Puente, Rosa María ;
Tejera Techera, Andrea ;
Terreros Barrios, Nicolasa ;
Vázquez Clavera, María Inés ;
Leiva-Guerrero, María Verónica ;
Valdés Gázquez, María
La aportación actual no entra en analizar aspectos generales de la pandemia (naturaleza, origen, extensión general y en el país, etc. ) o de otras situaciones que se derivan del confinamiento, por considerar que son suficientemente conocidos. [...]
Barcelona EDO-SERVEIS - Universitat Autònoma de Barcelona 2021 (Informes)
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19.
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15 p, 379.1 KB |
El viaje del escritor fronterizo al "otro lado"
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Hernández Quezada, Francisco Javier (Universidad Autónoma de Baja California)
Este artículo revisa la temática del viaje realizado por escritores de Tijuana al cruzar la frontera México-Estados Unidos y plasmar las percepciones que el Estado de California y algunas de sus ciudades les genera. [...]
Aquest article revisa la temàtica del viatge realitzat per escriptors de Tijuana en travessar la frontera Mèxic-Estats Units i plasmar les percepcions que l'Estat de Califòrnia i algunes de les seves ciutats els genera. [...]
This article reviews the theme of the border trip made by writers of Tijuana when crossing the Mexico-United States border and reflects the perceptions that the state of California and some of its cities generates. [...]
2021 - 10.5565/rev/mitologias.784
Mitologías hoy, Vol. 23 (2021) , p. 119-133 (Dossier)
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20.
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14 p, 502.9 KB |
Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe
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Pinato, David J. (Imperial College London. Department of Surgery & Cancer) ;
Lee, Alvin J. X. (University College London Hospitals) ;
Biello, Federica (University of Piemonte Orientale) ;
Seguí, Elia (Hospital Clínic i Provincial de Barcelona) ;
Aguilar-Company, Juan (Hospital Universitari Vall d'Hebron) ;
Carbó, Anna (Hospital Universitari de Girona Doctor Josep Trueta) ;
Bruna, Riccardo (University of Piemonte Orientale) ;
Bower, Mark (Chelsea & Westminster Hospital) ;
Rizzo, Gianpiero (Fondazione IRCCS Policlinico San Matteo) ;
Benafif, Sarah (University College London Hospitals) ;
Carmona, Carme (Hospital Universitari de Girona Doctor Josep Trueta) ;
Chopra, Neha (University College London Hospitals) ;
Cruz, Claudia Andrea (Hospital Clínic i Provincial de Barcelona) ;
D'avanzo, Francesca (University of Piemonte Orientale) ;
Evans, Joanne S. (Imperial College London) ;
Galazi, Myria (University College London Hospitals) ;
Garcia-Fructuoso, Isabel (Hospital Universitari de Girona Doctor Josep Trueta) ;
Pria, Alessia D. (Chelsea & Westminster Hospital) ;
Newsom-Davis, Thomas (Chelsea & Westminster Hospital) ;
Ottaviani, Diego (University College London Hospitals) ;
Patriarca, Andrea (University of Piemonte Orientale) ;
Reyes, Roxana (Hospital Clínic i Provincial de Barcelona) ;
Sharkey, Rachel (University of Piemonte Orientale) ;
Sng, Christopher C. T. (University College London Hospitals) ;
Wong, Yien Ning Sophia (University College London Hospitals) ;
Ferrante, Daniela (University of Piemonte Orientale) ;
Scotti, Lorenza (University of Piemonte Orientale) ;
Avanzi, Gian Carlo (University of Piemonte Orientale) ;
Bellan, Mattia (University of Piemonte Orientale) ;
Castello, Luigi Mario (University of Piemonte Orientale) ;
Marco-Hernández, Javier (Hospital Clínic i Provincial de Barcelona) ;
Mollà, Meritxell (Hospital Clínic i Provincial de Barcelona) ;
Pirisi, Mario (University of Piemonte Orientale) ;
Ruiz-Camps, Isabel (Hospital Universitari Vall d'Hebron) ;
Sainaghi, Pier Paolo (University of Piemonte Orientale) ;
Gaidano, Gianluca (University of Piemonte Orientale) ;
Brunet, Joan (Hospital Universitari de Girona Doctor Josep Trueta) ;
Tabernero, Josep (Vall d'Hebron Institut d'Oncologia) ;
Prat, Aleix (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gennari, Alessandra (University of Piemonte Orientale) ;
Universitat Autònoma de Barcelona
We describe the outcomes in cancer patients during the initial outbreak of the COVID-19 in Europe from the retrospective, multi-center observational OnCovid study. We identified 204 cancer patients from eight centers in the United Kingdom, Italy, and Spain aged > 18 (mean = 69) and diagnosed with COVID-19 between February 26th and April 1st, 2020. [...]
2020 - 10.3390/cancers12071841
Cancers, Vol. 12 Núm. 7 (july 2020) , p. 1-13
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