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13 p, 938.1 KB |
Cost-Effectiveness Analysis of Triple Therapy with Budesonide/ Glycopyrronium/ Formoterol Fumarate versus Dual Therapy in Patients with Chronic Obstructive Pulmonary Disease in Spain
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Trigueros, Juan Antonio (Servicio de Salud de Castilla-La Mancha) ;
Garin, Noe (Institut d'Investigació Biomèdica Sant Pau) ;
Baloira, Adolfo (Hospital Universitario de Pontevedra) ;
Aceituno, Susana (Outcomes'10) ;
Calvo, Ana (Outcomes'10) ;
Prades, Miriam (Outcomes'10) ;
Touron, Carolina (AstraZeneca Farmacéutica España) ;
Martínez, Anisia (AstraZeneca Farmacéutica España) ;
Torres, Covadonga (AstraZeneca Farmacéutica España) ;
Universitat Autònoma de Barcelona
To evaluate the cost-effectiveness of Budesonide/Glycopyrronium/Formoterol (BUD/GLY/FOR) versus LAMA/LABA and ICS/ LABA, respectively, in patients with moderate to severe COPD, from the Spanish National Healthcare System (NHS) perspective. [...]
2022 -  10.2147/COPD.S384591
International journal of COPD, Vol. 17 (2022) , p. 2905-2917
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10 p, 1.8 MB |
A proposed approach to chronic airway disease (CAD) using therapeutic goals and treatable traits : A look to the future
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Pérez de Llano, Luis (University Hospital Lucus Augusti (Lugo, Galícia)) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Golpe, Rafael (University Hospital Lucus Augusti (Lugo, Galícia)) ;
Alvarez Gutiérrez, Francisco Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Cisneros, Carolina (Hospital Universitario La Princesa (Madrid)) ;
Almonacid, Carlos (Hospital Universitario Ramón y Cajal (Madrid)) ;
Martínez-Moragón, Eva (Hospital Universitari Doctor Peset (València)) ;
González-Barcala, Francisco-Javier (Universidade de Santiago de Compostela) ;
Ramos-Barbón, David (Institut d'Investigació Biomèdica Sant Pau) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
López-Campos, José Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
De Torres, Juan Pablo (Queen's University) ;
Casanova Macario, Ciro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
García-Rivero, J. L. (Hospital de Laredo) ;
Rodriguez Hermosa, Juan Luis (Hospital Clínico San Carlos (Madrid)) ;
Calle Rubio, Myriam (Hospital Clínico San Carlos (Madrid)) ;
Soler-Cataluña, Juan José (Hospital Arnau de Vilanova (València)) ;
Cosio, Borja G (Clínica Quirón-Rotger) ;
Universitat Autònoma de Barcelona
Chronic airflow obstruction affects a wide range of airway diseases, the most frequent of which are asthma, COPD, and bronchiectasis; they are clearly identifiable in their extremes, but quite frequently overlap in some of their pathophysiological and clinical characteristics. [...]
2020 - 10.2147/COPD.S263430
International journal of COPD, Vol. 15 (2020) , p. 2091-2100
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12 p, 2.1 MB |
Long-Term Risk of Mortality Associated with Isolation of Pseudomonas aeruginosa in COPD : A Systematic Review and Meta-Analysis
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Martinez-García, Miguel Angel (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Rigau, David (Institut d'Investigació Biomèdica Sant Pau) ;
Barrecheguren, Miriam (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Ortega, Alberto (Hospital Universitari i Politècnic La Fe (València)) ;
Nuñez, Alexa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Oscullo Yepez, Grace (Hospital Universitari i Politècnic La Fe (València)) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Background: Chronic bronchial infection is frequent in chronic obstructive pulmonary disease (COPD), but the impact of the isolation of pathogenic bacteria, and in particular Pseudomonas aeruginosa (PA) in respiratory samples on the prognosis of COPD is unclear. [...]
2022 - 10.2147/COPD.S346294
International journal of COPD, Vol. 17 (2022) , p. 371-382
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11 p, 2.2 MB |
Trends in Diagnosis of Alpha-1 Antitrypsin Deficiency Between 2015 and 2019 in a Reference Laboratory
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Belmonte, Irene (Hospital Universitari Vall d'Hebron) ;
Núñez, Alexa (Universitat Autònoma de Barcelona) ;
Barrecheguren, Miriam (Hospital Universitari Vall d'Hebron) ;
Esquinas, Cristina (Hospital Universitari Vall d'Hebron) ;
Pons Delgado, Mònica (Hospital Universitari Vall d'Hebron) ;
Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ;
Ruiz, Gerard (Hospital Universitari Vall d'Hebron) ;
Blanco-Grau, Albert (Hospital Universitari Vall d'Hebron) ;
Ferrer-Costa, Roser (Hospital Universitari Vall d'Hebron) ;
Genescà Ferrer, Joan (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Miravitlles, Marc (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron)
Alpha-1 antitrypsin deficiency (AATD) remains largely underdiagnosed despite recommendations of healthcare institutions and programmes designed to increase awareness. The objective was to analyse the trends in AATD diagnosis during the last 5 years in a Spanish AATD reference laboratory. [...]
2020 - 10.2147/COPD.S269641
International journal of COPD, Vol. 15 (october 2020) , p. 2421-2431
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10 p, 685.5 KB |
Association Between Routine Blood Biomarkers and Clinical Phenotypes and Exacerbations in Chronic Obstructive Pulmonary Disease
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Núñez, Alexa (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Marras, Viviana (Respiratory Unit, AOU Sassari) ;
Harlander, Matevz (University Medical Centre Ljubljana) ;
Mekov, Evgeni (Medical University of Sofia) ;
Esquinas, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Turel, Matjaz (University Medical Centre Ljubljana) ;
Lestan, David (University Medical Centre Ljubljana) ;
Petkov, Rosen (Medical University of Sofia) ;
Yanev, Nikolay (Medical University of Sofia) ;
Pirina, Pietro (Respiratory Unit, AOU Sassari) ;
Negri, Silvia (Respiratory Unit, AOU Sassari) ;
Miravitlles, Marc (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Barrecheguren, Miriam (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Chronic obstructive pulmonary disease (COPD) is associated with increased lung and systemic inflammation. We aimed to identify associations between easy-to-obtain blood biomarkers and the frequency and severity of exacerbations. [...]
2020 - 10.2147/COPD.S240720
International journal of COPD, Vol. 15 (march 2020) , p. 681-690
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10 p, 5.1 MB |
Does the Efficacy of High Intensity Ventilation in Stable COPD Depend on the Ventilator Model? A Bench-to-Bedside Study
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Lalmolda, Cristina (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Flórez, Pablo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Corral, Marta (Hospital Universitario 12 de Octubre (Madrid)) ;
Hernández Voth, Ana (Hospital Universitario 12 de Octubre (Madrid)) ;
Grimau, Carles (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Sayas, Javier (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Luján, Manel (Universitat Autònoma de Barcelona) ;
Universitat Autònoma de Barcelona
The European Task Force for chronic non-invasive ventilation in stable COPD recommends the use of high pressure-support (PS) level to maximize the decrease in PaCO2. It is possible that the ventilator model can influence the need for higher or lower pressure levels. [...]
2022 - 10.2147/COPD.S327994
International journal of COPD, Vol. 17 (january 2022) , p. 155-164
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7 p, 681.5 KB |
Bispectral index in hypercapnic encephalopathy associated with COPD exacerbation : a pilot study
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Chalela, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gallart, Lluís (Universitat Autònoma de Barcelona. Departament de Cirurgia) ;
Pascual-Guardia, Sergi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sancho-Muñoz, Antonio (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gea Guiral, Joaquim (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Orozco-Levi, Mauricio (Institut Hospital del Mar d'Investigacions Mèdiques)
Hypercapnic encephalopathy is relatively frequent in severe exacerbations of COPD (ECOPDs), with its intensity usually being evaluated through clinical scales. Bispectral index (BIS) is a relatively new technique, based on the analysis of the electroencephalographic signal, which provides a good approximation to the level of consciousness, having already been validated in anesthesia. [...]
2018 - 10.2147/COPD.S167020
International journal of COPD, Vol. 13 (september 2018) , p. 2961-2967
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4 p, 174.2 KB |
Is iron deficiency modulating physical activity in COPD?
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Martín-Ontiyuelo, Clara (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodó-Pin, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sancho-Muñoz, Antonio (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Martinez-Llorens, Juana María (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Admetlló, Mireia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Molina, Lluis (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gea Guiral, Joaquim (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Barreiro, Esther (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Chiaradía, Diego A. Rodríguez (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
There is evidence that iron plays a key role in the adequate functioning of skeletal muscle. While it has been demonstrated that nonanemic iron deficiency (NAID) affects exercise tolerance and response to exercise training in patients with COPD, the impact on daily physical activities (DPAs) remains unknown. [...]
2019 - 10.2147/COPD.S182700
International journal of COPD, Vol. 14 (january 2019) , p. 211-214
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9 p, 2.6 MB |
Nebulized colistin and continuous cyclic azithromycin in severe COPD patients with chronic bronchial infection due to pseudomonas aeruginosa : A retrospective cohort study
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Montón, Concepción (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Prina, Elena (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pomares, Xavier (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Cugat, Jose R. (Department of Respiratory Medicine. Fundació Althaia) ;
Casabella Pernas, Antonio (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Oliva, Joan Carles (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Gallego, Miguel (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Monsó, Eduard (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Introduction: Long-term use of nebulized or oral antibiotics is common in the treatment of cystic fibrosis and non-cystic fibrosis bronchiectasis. To date, however, few studies have focused on the use of nebulized antibiotics in COPD patients. [...]
2019 - 10.2147/COPD.S209513
International journal of COPD, Vol. 14 (2019) , p. 2365-2373
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14 p, 1.0 MB |
Withdrawal of inhaled corticosteroids in COPD patients : Rationale and algorithms
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Avdeev, S. (Clinical Department. Federal Pulmonology Research Institute. Federal Medical and Biological Agency of Russia) ;
Aisanov, Z. (Department of Pulmonology. N.I. Pirogov Russian State National Research Medical University) ;
Arkhipov, V. (Department of Clinical Pharmacology and Therapy. Russian Medical Academy of Continuous Professional Education) ;
Belevskiy, A. (Department of Pulmonology. N.I. Pirogov Russian State National Research Medical University) ;
Leshchenko, I. (Department of Phthisiology. Pulmonology and Thoracic Surgery. Ural State Medical University) ;
Ovcharenko, S. (Department of Internal Diseases No.1. I.M. Sechenov First Moscow State Medical University) ;
Shmelev, E. (Department of Differential Diagnostics. Federal Central Research Institute of Tuberculosis) ;
Miravitlles, Marc. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Observational studies indicate that overutilization of inhaled corticosteroids (ICS) is common in patients with chronic obstructive pulmonary disease (COPD). Overprescription and the high risk of serious ICS-related adverse events make withdrawal of this treatment necessary in patients for whom the treatment-related risks outweigh the expected benefits. [...]
2019 - 10.2147/COPD.S207775
International journal of COPD, Vol. 14 (2019) , p. 1267-1280
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