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16 p, 5.9 MB |
Adipokines as New Biomarkers of Immune Recovery : Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy
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Yeregui, Elena (Instituto de Salud Carlos III) ;
Masip, J. (Instituto de Salud Carlos III) ;
Viladés, C. (Instituto de Salud Carlos III) ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Pacheco, Y.M. (Universidad de Sevilla) ;
Blanco, J. (Universitat de Vic - Universitat Central de Catalunya) ;
Mallolas Masferrer, Josep (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Alba, Verónica (Instituto de Salud Carlos III) ;
Vargas, M. (Instituto de Salud Carlos III) ;
García-Pardo, G. (Instituto de Salud Carlos III) ;
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Olona, M. (Instituto de Salud Carlos III) ;
Vidal-González, J. (Universitat de Barcelona) ;
Peraire, M. (Universitat Rovira i Virgili) ;
Martí, A. (Instituto de Salud Carlos III) ;
Reverté, L. (Instituto de Salud Carlos III) ;
Gómez-Bertomeu, F. (Instituto de Salud Carlos III) ;
Leal, M. (Hospital Viamed Santa Ángela de la Cruz) ;
Vidal, F. (Instituto de Salud Carlos III) ;
Peraire, J. (Instituto de Salud Carlos III) ;
Rull, A. (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4 T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. [...]
2022 -  10.3390/ijms23042202
International journal of molecular sciences, Vol. 23 Núm. 4 (2-2 2022) , p. 2202
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17 p, 3.9 MB |
Hypercholesterolemia-Induced HDL Dysfunction Can Be Reversed : The Impact of Diet and Statin Treatment in a Preclinical Animal Model
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Schoch, Leonie (Institut d'Investigació Biomèdica Sant Pau) ;
Sutelman, P. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Suades, Rosa (Institut d'Investigació Biomèdica Sant Pau) ;
Casani, L. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
High-density lipoproteins (HDL) undergo adverse remodeling and loss of function in the presence of comorbidities. We assessed the potential of lipid-lowering approaches (diet and rosuvastatin) to rescue hypercholesterolemia-induced HDL dysfunction. [...]
2022 - 10.3390/ijms23158596
International journal of molecular sciences, Vol. 23 Núm. 15 (august 2022) , p. 8596
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25 p, 6.8 MB |
Role of Ion Channels in the Maintenance of Sperm Motility and Swimming Behavior in a Marine Teleost
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Castro-Arnau, Júlia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Chauvigné, François (Institut de Ciències del Mar) ;
Cerdà, Joan (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
In oviparous marine fishes, the hyperosmotic induction of sperm motility in seawater (SW) is well established, however, the potential function of ion channels in the maintenance of post activated spermatozoon swimming performance remains largely unknown. [...]
2022 - 10.3390/ijms232012113
International journal of molecular sciences, Vol. 23, Issue 20 (October 2022) , art. 12113
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19 p, 2.4 MB |
Global Impairment of Immediate-Early Genes Expression in Rett Syndrome Models and Patients Linked to Myelination Defects
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Petazzi, Paolo (Instituto de Salud Carlos III) ;
Jorge-Torres, Olga Caridad (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gomez, Antonio (Universitat de Vic - Universitat Central de Catalunya) ;
Scognamiglio, Iolanda (Institut d'Investigació Biomèdica de Bellvitge) ;
Serra-Musach, Jordi (Institut d'Investigació Biomèdica de Bellvitge) ;
Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Grases, Daniela (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Xiol, Clara (Hospital Sant Joan de Déu (Manresa)) ;
O'Callaghan, Maria del Mar (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Armstrong, Judith (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Rett syndrome (RTT) is a severe neurodevelopmental disease caused almost exclusively by mutations to the MeCP2 gene. This disease may be regarded as a synaptopathy, with impairments affecting synaptic plasticity, inhibitory and excitatory transmission and network excitability. [...]
2023 - 10.3390/ijms24021453
International journal of molecular sciences, Vol. 24 Núm. 2 (january 2023)
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27 p, 3.9 MB |
The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks
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Pereira, Quélita Cristina (Sao Francisco University Medical School, Brazil) ;
dos Santos, Tanila Wood (Sao Francisco University Medical School, Brazil) ;
Fortunato, Isabela Monique (Sao Francisco University Medical School, Brazil) ;
Ribeiro, Marcelo Lima (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Ageing is a complex process characterized mainly by a decline in the function of cells, tissues, and organs, resulting in an increased risk of mortality. This process involves several changes, described as hallmarks of ageing, which include genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell depletion, and altered intracellular communication. [...]
2023 - 10.3390/ijms24065508
International journal of molecular sciences, Vol. 24 Núm. 6 (march 2023)
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11 p, 771.0 KB |
Do GWAS-Identified Risk Variants for Chronic Lymphocytic Leukemia Influence Overall Patient Survival and Disease Progression?
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Cabrera Serrano, Antonio José (Instituto de Investigación Sanitaria de Granada) ;
Sánchez Maldonado, José Manuel (Instituto de Investigación Sanitaria de Granada) ;
ter Horst, Rob (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences) ;
Macauda, Angelica (German Cancer Research Center) ;
García Martín, Paloma (Hospital Campus de la Salud (Granada)) ;
Benavente, Yolanda (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Landi, Stefano (Department of Biology. University of Pisa) ;
Clay-Gilmour, Alyssa (Department of Epidemiology & Biostatistics. Arnold School of Public Health. University of South Carolina) ;
Niazi, Yasmeen (Hopp Children's Cancer Center) ;
Espinet, Blanca (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodriguez-Sevilla, Juan Jose (Department of Leukemia. The University of Texas MD Anderson Cancer Center) ;
Pérez, Eva María (Hospital Campus de la Salud) ;
Maffei, Rossana (University of Modena and Reggio Emilia) ;
Blanco, Gonzalo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giaccherini, Matteo (Department of Biology. University of Pisa) ;
Cerhan, James R. (Department of Quantitative Health Sciences. Mayo Clinic) ;
Marasca, Roberto (Department of Medical and Surgical Sciences. University of Modena and Reggio Emilia. AOU Policlinico) ;
Lopez Nevot, Miguel Angel (Hospital Universitario Virgen de las Nieves (Granada)) ;
Chen-Liang, Tzu Hua (Hospital Universitario Morales Meseguer (Múrcia)) ;
Thomsen, Hauke (MSB Medical School Berlin) ;
Gámez, Irene (Hematology Department. Morales Meseguer University Hospital) ;
Campa, Daniele (Department of Biology. University of Pisa) ;
Moreno Aguado, Víctor (Facultat de Medicina. Universitat de Barcelona) ;
de Sanjosé, Silvia (Universitat de Barcelona) ;
Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Álvarez, María Flor (Instituto de Investigación Biomédica de Salamanca) ;
Dierssen-Sotos, Trinidad (Universidad de Cantabria) ;
Jerez, Andrés (Vall d'Hebron Institut d'Oncologia) ;
Butrym, Aleksandra (Department of Cancer Prevention and Therapy. Medical University of Wrocław) ;
Norman, Aaron D. (Department of Quantitative Health Sciences. Mayo Clinic) ;
Luppi, Mario (University of Modena and Reggio Emilia) ;
Slager, Susan L. (Mayo Clinic) ;
Hemminki, Kari (Charles University in Prague) ;
Li, Yang (Hannover Medical School) ;
Berndt, Sonja I. (National Institutes of Health (Estats Units d'Amèrica)) ;
Casabonne, Delphine (Universitat de Barcelona) ;
Alcoceba, Miguel (Instituto de Investigación Biomédica de Salamanca) ;
Puiggros, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Netea, Mihai G. (Department for Immunology & Metabolism. University of Bonn) ;
Försti, Asta (Hopp Children's Cancer Center) ;
Canzian, Federico (German Cancer Research Center) ;
Sainz, Juan (Department of Biochemistry and Molecular Biology. Universidad de Granada)
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. Although genome-wide association studies (GWAS) have uncovered the germline genetic component underlying CLL susceptibility, the potential use of GWAS-identified risk variants to predict disease progression and patient survival remains unexplored. [...]
2023 - 10.3390/ijms24098005
International journal of molecular sciences, Vol. 24 Núm. 9 (may 2023) , p. 8005
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15 p, 2.4 MB |
Hyperuricaemia Does Not Interfere with Aortopathy in a Murine Model of Marfan Syndrome
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Rodríguez-Rovira, Isaac (Universitat de Barcelona) ;
López-Sainz, Angela (Hospital Clínic i Provincial de Barcelona) ;
Palomo-Buitrago, Maria Encarnación (Universitat de Barcelona) ;
Pérez, Belén (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Jiménez Altayó, Francesc (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Campuzano, Victoria (Universitat de Barcelona) ;
Egea, Gustavo (Universitat de Barcelona)
Redox stress is involved in the aortic aneurysm pathogenesis in Marfan syndrome (MFS). We recently reported that allopurinol, a xanthine oxidoreductase inhibitor, blocked aortopathy in a MFS mouse model acting as an antioxidant without altering uric acid (UA) plasma levels. [...]
2023 - 10.3390/ijms241411293
International journal of molecular sciences, Vol. 24 Núm. 14 (2023) , p. 11293
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15 p, 1.2 MB |
Programmed death-ligand (PD-L1), epidermal growth factor (EGF), relaxin and metalloproteinase-3 (MMP3), potential biomarkers of malignancy in canine mammary neoplasia
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Galadima, Makchit ;
Teles, Mariana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Pastor Milán, Josep (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Rodríguez Gil, Joan Enric (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Rivera del Álamo, Maria Montserrat (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Gene expression has been suggested as a putative tool for prognosis and diagnosis in canine mammary neoplasia (CMNs). In the present study, 58 formalin-fixed paraffin-embedded (FFPE) paraffined canine mammary neoplasias from 27 different bitches were included. [...]
2024 - 10.3390/ijms25021170
International journal of molecular sciences, Vol. 25 (2024) , p. 1170
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