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4 p, 551.6 KB |
Regions of homozygosity confer a worse prognostic impact in myelodysplastic syndrome with normal karyotype
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Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tuechler, Heinz (Boltzmann Institute for Leukaemia Research and Hematology) ;
Arenillas, Leonor (Hospital del Mar (Barcelona, Catalunya)) ;
Raynaud, Sophie (Cote d'Azur University) ;
Cluzeau, Thomas (Cote d'Azur University) ;
Shih, Lee-Yung (Chang Gung University) ;
Tung-Liang, Chiang (Chang Gung University) ;
Ganster, Christina (University Medical Center Göttingen) ;
Shirneshan, Katayoon (University Medical Center Göttingen) ;
Haase, Detlef (University Medical Center Göttingen) ;
Mascaró, Martí (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Palomo Sanchís, Laura (Vall d'Hebron Institut d'Oncologia) ;
Cervera, José (Hospital Universitari i Politècnic La Fe (València)) ;
Such, Esperanza (Hospital Universitari i Politècnic La Fe (València)) ;
Trim, Nicola (Birmingham Women's Hospital) ;
Jeffries, Sally (Birmingham Women's Hospital) ;
Ridgway, Emma (Birmingham Women's Hospital) ;
Marconi, Giovanni (IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori") ;
Martinelli, Giovanni (IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori") ;
Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Half of the myelodysplastic syndromes (MDS) have normal karyotype by conventional banding analysis. The percentage of true normal karyotype cases can be reduced by 20-30% with the complementary application of genomic microarrays. [...]
2023 -  10.1002/jha2.651
EJHaem, Vol. 4 (february 2023) , p. 446-449
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2.
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14 p, 1.0 MB |
CD34 + CD19 − CD22 + B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies
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Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Barrera, Susana (Universidad de Salamanca) ;
Bataller, Alex (Hospital Clínic i Provincial de Barcelona) ;
Ortiz-Maldonado, Valentín (Hospital Clínic i Provincial de Barcelona) ;
Elliot, Natalina (John Radcliffe Hospital (Oxford, Regne Unit)) ;
O'Byrne, Sorcha (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Wang, Guanlin (University of Oxford) ;
Rovira, Montse (University of Oxford) ;
Gutiérrez-Agüera, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Trincado Alonso, Juan Luis, 1987- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
González-González, María (Universidad de Salamanca) ;
Morgades, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sorigue, Marc (Universitat Autònoma de Barcelona) ;
Bárcena, Paloma (Universidad de Salamanca) ;
Zanetti, S. R (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Torrebadell, Montse (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Vega-Garcia, Nerea (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Rives, Susana (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Mallo, Maria del Mar (Universitat Autònoma de Barcelona) ;
Sole, F (Universitat Autònoma de Barcelona) ;
Mead, Adam J. (Centro Nacional de Investigaciones Oncológicas Carlos III (Espanya)) ;
Roberts, Irene (Oxford Biomedical Research Centre) ;
Thongjuea, Supat (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Psaila, Bethan (Oxford Biomedical Research Centre) ;
Juan, Manel (Hospital Clínic i Provincial de Barcelona) ;
Delgado, Julio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Urbano-Ispizúa, Alvaro (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ribera, Jose-Maria (Universitat Autònoma de Barcelona) ;
Orfao, Alberto (Universidad de Salamanca) ;
Roy, Anindita (Oxford Biomedical Research Centre) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Three article in this issue present preclinical data aimed at improving immunotherapeutic approaches for relapsed B- and T-cell acute lymphoblastic leukemia (T-ALL). Chimeric antigen receptor T (CAR-T) cell therapy directed against relapsed T-ALL is hampered by difficulty in identifying a target antigen that is not also expressed on healthy T cells, risking "fratricide" with T-cell aplasia and loss of the CAR-T cells. [...]
2022 - 10.1182/blood.2021014840
Blood, Vol. 140 (july 2022) , p. 38-44
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3.
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13 p, 3.0 MB |
Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q
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Ademà, Vera (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute) ;
Palomo Sanchís, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Walter, Wencke (Munich Leukemia Laboratory) ;
Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Hutter, Stephan (Munich Leukemia Laboratory) ;
La Framboise, Thomas (Department of Genetics and Genome Sciences. Case Western Reserve University) ;
Arenillas, Leonor (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Meggendorfer, Manja (Munich Leukemia Laboratory) ;
Radivoyevitch, Tomas (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute) ;
Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pellagatti, Andrea (Blood Cancer UK Molecular Haematology Unit. Nuffield Division of Clinical Laboratory Sciences. Radcliffe Department of Medicine. University of Oxford and Oxford BRC Haematology Theme) ;
Haferlach, Claudia (Munich Leukemia Laboratory) ;
Boultwood, Jacqueline (University of Oxford. Radcliffe Department of Medicine) ;
Kern, Wolfgang (Munich Leukemia Laboratory) ;
Visconte, Valeria (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute) ;
Sekeres, Mikkael (Leukemia Program. Department of Hematology and Medical Oncology. Cleveland Clinic. Cleveland Clinic Taussig Cancer Institute) ;
Barnard, John (Department of Quantitative Health Sciences. Cleveland Clinic. Lerner Research Institute) ;
Haferlach, Torsten (Munich Leukemia Laboratory) ;
Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Maciejewski, Jaroslaw (Department of Translational Hematology and Oncology Research. Lerner Research Institute. Cleveland Clinic. Taussig Cancer Institute)
Background: Haploinsufficiency (HI) resulting from deletion of the long arm of chromosome 5 [del(5q)] and the accompanied loss of heterozygosity are likely key pathogenic factors in del(5q) myeloid neoplasia (MN) although the consequences of del(5q) have not been yet clarified. [...]
2022 - 10.1016/j.ebiom.2022.104059
EBioMedicine, Vol. 80 (june 2022) , art. 104059
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11 p, 1.5 MB |
Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18
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Maher, Michael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Le Pannérer, Marguerite Marie (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cabezón, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vergara, Sara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Méndez López, Aleix (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mesa Tudel, Alba (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sorigue, Marc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Haematopoietic malignancies are frequently characterized by karyotypic abnormalities. The development of targeted drugs has been pioneered with compounds against gene products of fusion genes caused by chromosomal translocations. [...]
2021 - 10.1038/s41598-021-00623-w
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 21145
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12 p, 1.0 MB |
Guiding the global evolution of cytogenetic testing for hematologic malignancies
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Akkari, Yassmine M.N. (Departments of Cytogenetics and Molecular Pathology. Legacy Health (Estats Units d'Amèrica)) ;
Baughn, Linda B. (Mayo Clinic) ;
Dubuc, Adrian M. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Smith, Adam C. (University of Toronto) ;
Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Dal Cin, Paola (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Diez-Campelo, María (Instituto de Investigación Biomédica de Salamanca) ;
Gallego, Marta S. (Italian Hospital) ;
Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Haase, Detlef (University Medical Center Göttingen) ;
Schlegelberger, Brigitte (Department of Human Genetics. Hannover Medical School) ;
Slavutsky, Irma (Institute of Experimental Medicine) ;
Mecucci, Cristina (Hematology University of Perugia) ;
Levine, Ross L. (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica)) ;
Hasserjian, Robert P. (Massachusetts General Hospital (Boston)) ;
Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Levy, Brynn (Columbia University Medical Center) ;
Xu, Xinjie (Mayo Clinic) ;
Universitat Autònoma de Barcelona
2022 - 10.1182/blood.2021014309
Blood, Vol. 139 Núm. 15 (14 2022) , p. 2273-2284
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6.
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11 p, 1.7 MB |
In silico validation of RNA-Seq results can identify gene fusions with oncogenic potential in glioblastoma
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Hernández, Ainhoa (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Muñoz-Mármol, Ana Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Esteve-Codina, Anna (Universitat Pompeu Fabra) ;
Alameda, Francesc (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pineda, Estela (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Arpí Lluciá, Oriol (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Martinez-García, Maria (Hospital del Mar (Barcelona, Catalunya)) ;
Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gut, Marta (Universitat Pompeu Fabra) ;
Del Barco Berrón, Sonia (Hospital Universitari de Girona Doctor Josep Trueta) ;
Gallego Rubio, Oscar (Institut d'Investigació Biomèdica Sant Pau) ;
Dabad, Marc (Universitat Pompeu Fabra) ;
Mesia, Carlos (Institut d'Investigació Biomèdica de Bellvitge) ;
Bellosillo Paricio, Beatriz (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Domènech Viñolas, Marta (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Vidal, Noemí (Hospital Universitari de Bellvitge) ;
Aldecoa, Iban (Universitat de Barcelona) ;
de la Iglesia, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Balañá, Carmen (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Universitat Autònoma de Barcelona
RNA-Sequencing (RNA-Seq) can identify gene fusions in tumors, but not all these fusions have functional consequences. Using multiple data bases, we have performed an in silico analysis of fusions detected by RNA-Seq in tumor samples from 139 newly diagnosed glioblastoma patients to identify in-frame fusions with predictable oncogenic potential. [...]
2022 - 10.1038/s41598-022-18608-8
Scientific reports, Vol. 12 Núm. 1 (december 2022) , p. 14439
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469.5 KB |
Targeted deep sequencing of CD34+ cells from peripheral blood can reproduce bone marrow molecular profile in myelodysplastic syndromes
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Martin, Roman (University Medical Center Göttingen) ;
Acha, Pamela (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ganster, Christina (University Medical Center Göttingen) ;
Palomo Sanchís, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Dierks, Sascha (University Medical Center Göttingen) ;
Fuster-Tormo, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ademà, Vera (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gómez-Marzo, Paula (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
De Haro, Nuri (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Solanes, Neus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Shirneshan, Katayoon (University Medical Center Göttingen) ;
Flach, Johanna (University Medical Center Göttingen) ;
Braulke, Friederike (University Medical Center Göttingen) ;
Schanz, Julie (University Medical Center Göttingen) ;
Kominowski, Arkadiusz (University Medical Center Göttingen) ;
Stromburg, Martin (University Medical Center Göttingen) ;
Brockmann, Alina (University Medical Center Göttingen) ;
Trümper, Lorenz (University Medical Center Göttingen) ;
Sole, F. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Haase, Detlef (University Medical Center Göttingen) ;
Universitat Autònoma de Barcelona
2018 - 10.1002/ajh.25089
American Journal of Hematology, Vol. 93 (april 2018) , p. E152-E154
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17 p, 2.3 MB |
Analysis of Intratumoral Heterogeneity in Myelodysplastic Syndromes with Isolated del(5q) Using a Single Cell Approach
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Acha, Pamela (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Manzanares Mileo, Ana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Grau Cat, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Marcé, Silvia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez-Luaces, Marta (Hospital de Tortosa Verge de la Cinta) ;
Diez-Campelo, María (Hospital Universitario de Salamanca) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sole, F. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Palomo Sanchís, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fuster-Tormo, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematological diseases. Among them, the most well characterized subtype is MDS with isolated chromosome 5q deletion (MDS del(5q)), which is the only one defined by a cytogenetic abnormality that makes these patients candidates to be treated with lenalidomide. [...]
2021 - 10.3390/cancers13040841
Cancers, Vol. 13 Núm. 4 (2021) , p. 841
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15 p, 1.7 MB |
Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications
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Carrillo-Reixach, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torrens, L. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Simón-Coma, Marina (Institut Germans Trias i Pujol) ;
Royo, Laura (Institut Germans Trias i Pujol) ;
Domingo-Sàbat, Montse (Institut Germans Trias i Pujol) ;
Abril-Fornaguera, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Akers, N. (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica)) ;
Sala Llinas, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ragull, Sonia (Institut Germans Trias i Pujol) ;
Arnal, Magdalena (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Villalmanzo, Núria (Institut Germans Trias i Pujol) ;
Cairo, Stefano (Instituto di Ricerca Pediatrica. Corso Stati Uniti 4) ;
Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Kappler, R. (Department of Pediatric Surgery. Dr. von Hauner Children's Hospital. Ludwig-Maximilians-University Munich) ;
Garrido-Pontnou, Marta (Hospital Universitari Vall d'Hebron) ;
Guerra, Laura (Hospital Universitario La Paz (Madrid)) ;
Sábado, Constantino (Hospital Universitari Vall d'Hebron) ;
Guillén, Gabriela (Hospital Universitari Vall d'Hebron) ;
Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Piñeyro, David (Institut Germans Trias i Pujol) ;
Vázquez-Vitali, María (Institut Germans Trias i Pujol) ;
Kuchuk, O. (Mount Sinai Liver Cancer Program. Divisions of Liver Diseases. Tisch Cancer Institute. Icahn School of Medicine at Mount Sinai) ;
Mateos, María Elena (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Ramírez, G. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Santamaría, María (Hospital Universitario La Paz (Madrid)) ;
Mozo, Y. (Hospital Universitario La Paz (Madrid)) ;
Soriano, Aroa (Hospital Universitari Val d'Hebron. Institut de Recerca) ;
Grotzer, M. (Department of Pediatric Oncology. University Children's Hospital Zurich. University of Zurich) ;
Branchereau, S. (Bicêtre Hospital) ;
de Andoin, N. G. (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
López-Ibor, B. (Department of Pediatric Hematology and Oncology. HM Montepríncipe Hospital) ;
López-Almaraz, R. (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Salinas, J. A. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Torres, B. (Hospital Universitari i Politècnic La Fe (València)) ;
Hernández, Francisco (Hospital Universitario La Paz (Madrid)) ;
Uriz, J. J. (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
Fabre, M. (Department of Pathology. Hôpital Universitaire Necker-Enfants Malades. Assistance Publique-Hôpitaux de Paris. Université Paris Descartes) ;
Blanco, J. (Joan) (Joan) (Universitat de Vic - Universitat Central de Catalunya) ;
Paris, C. (Stem Cell Transplant Unit. Hospital Luis Calvo Mackenna) ;
Bajčiová, V. (Department of Pediatric Oncology. Childrens University Hospital Brno) ;
Laureys, G. (Ghent University Hospital. (Bèlgica)) ;
Masnou, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clos, Ariadna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Beléndez, Cristina (Hospital General Universitario Gregorio Marañón) ;
Guettier, C. (Bicêtre Hospital) ;
Sumoy, Lauro (Institut Germans Trias i Pujol) ;
Planas, Ramón (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nonell, Lara (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Czauderna, P. (Department of Surgery and Urology for Children and Adolescents. Medical University of Gdansk) ;
Morland, B. (Birmingham Women's Hospital) ;
Sia, D. (Mount Sinai Liver Cancer Program. Divisions of Liver Diseases. Tisch Cancer Institute. Icahn School of Medicine at Mount Sinai) ;
Losic, B. (Icahn Institute for Data Science and Genomic Technology (Nova York, Estats Units d'Amèrica)) ;
Buendia, M. A. (INSERM. UMR 1193. Paul-Brousse Hospital. Hepatobiliary Centre) ;
Sarrias, Maria-Rosa (Institut Germans Trias i Pujol) ;
Llovet, J. M. (Institució Catalana de Recerca i Estudis Avançats) ;
Armengol, Carolina (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Background & Aims: Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the predominant pediatric liver cancer, with limited therapeutic options for patients with aggressive tumors. Herein, we aimed to uncover the mechanisms of HB pathobiology and to identify new biomarkers and therapeutic targets in a move towards precision medicine for patients with advanced HB. [...]
2020 - 10.1016/j.jhep.2020.03.025
Journal of Hepatology, Vol. 73 Núm. 2 (august 2020) , p. 328-341
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