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Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia : a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)
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Welte, Tobias (Carl-Neuberg-Str. 1, 30625 Hannover, Germany) ;
Dellinger, R. Phillip (Camden, NJ USA) ;
Ebelt, Henning (Halle (Saale), Germany) ;
Ferrer, Miguel (Barcelona, Spain) ;
Opal, Steven M. (Providence, RI USA) ;
Singer, Mervyn (London, UK) ;
Vincent, Jean-Louis (Brussels, Belgium) ;
Werdan, Karl (Halle (Saale), Germany) ;
Martin-Loeches, Ignacio (Sabadell, Spain) ;
Almirall, Jordi (Hospital de Mataró) ;
Artigas, Antonio (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ignacio Ayestarán, Jose (Palma de Mallorca, Spain) ;
Nuding, Sebastian (Halle (Saale), Germany) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sirgo Rodríguez, Gonzalo (Tarragona, Spain) ;
Shankar-Hari, Manu (London, UK) ;
Álvarez-Lerma, Francisco (Hospital del Mar (Barcelona)) ;
Riessen, Reimer (Tübingen, Germany) ;
Sirvent, Josep-Maria (Servicio de Medicina Intensiva, Hospital U. Girona Dr. Josep Trueta, Avinguda França, Girona, Spain) ;
Kluge, Stefan (Hamburg, Germany) ;
Zacharowski, Kai (Frankfurt, Germany) ;
Bonastre Mora, Juan (Valencia, Spain) ;
Lapp, Harald (Medizinische Klinik, Kardiologie und Intensivmedizin, Helios Klinikum Erfurt, Erfurt, Germany) ;
Wöbker, Gabriele (Klinik für Intensivmedizin, Helios Universitätsklinikum Wuppertal, Wuppertal, Germany) ;
Achtzehn, Ute (Chemnitz, Germany) ;
Brealey, David (Critical Care Unit, NIHR University College London Hospitals Biomedical Research Centre, University College London Hospitals, NHS Foundation Trust, London, UK) ;
Kempa, Axel (Stuttgart, Germany) ;
Sánchez García, Miguel (Madrid, Spain) ;
Brederlau, Jörg (Helios Klinikum Berlin-Buch, Klinik für Intensivmedizin, Berlin, Germany) ;
Kochanek, Matthias (Cologne, Germany) ;
Reschreiter, Henrik Peer (Poole, Dorset UK) ;
Wise, Matthew P. (Heath Park, Cardiff, UK) ;
Belohradsky, Bernd H. (Munich, Germany) ;
Bobenhausen, Iris (Dreieich, Germany) ;
Dälken, Benjamin (Dreieich, Germany) ;
Dubovy, Patrick (Dreieich, Germany) ;
Langohr, Patrick (Dreieich, Germany) ;
Mayer, Monika (Dreieich, Germany) ;
Schüttrumpf, Jörg (Dreieich, Germany) ;
Wartenberg-Demand, Andrea (Dreieich, Germany) ;
Wippermann, Ulrike (Dreieich, Germany) ;
Wolf, Daniele (Dreieich, Germany) ;
Torres, Antoni (Barcelona, Spain)
The CIGMA study investigated a novel human polyclonal antibody preparation (trimodulin) containing ~ 23% immunoglobulin (Ig) M, ~ 21% IgA, and ~ 56% IgG as add-on therapy for patients with severe community-acquired pneumonia (sCAP). [...]
2018 -  10.1007/s00134-018-5143-7
Intensive Care Medicine, Vol. 44 (april 2018) , p. 438-448
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