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1.
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15 p, 2.7 MB |
Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccination
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Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prats, Anna (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Oriol-Tordera, Bruna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Muñoz-Moreno, Jose A. (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Hanke, Thomas (University of Oxford. The Jenner Institute) ;
Moltó, José (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Biomarkers predicting the outcome of HIV-1 virus control in natural infection and after therapeutic interventions in HIV-1 cure trials remain poorly defined. The BCN02 trial (NCT02616874), combined a T-cell vaccine with romidepsin (RMD), a cancer-drug that was used to promote HIV-1 latency reversal and which has also been shown to have beneficial effects on neurofunction. [...]
2023 -  10.1016/j.ebiom.2023.104732
EBioMedicine, Vol. 95 (september 2023)
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2.
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13 p, 849.9 KB |
Altered T-cell subset distribution in the viral reservoir in HIV-1-infected individuals with extremely low proviral DNA (LoViReTs)
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Gálvez, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Guerrero, María del Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bernal, Sílvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Benet, Susana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bailón, Lucía (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martinez, Andrea (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nieto Gil-Ortega, Aroa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Leal, Lorna (Hospital Clínic i Provincial de Barcelona) ;
García, Felipe (Hospital Clínic i Provincial de Barcelona) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Salgado, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
HIV cure strategies aim to eliminate viral reservoirs that persist despite successful antiretroviral therapy (ART). We have previously described that 9% of HIV-infected individuals who receive ART harbor low levels of provirus (LoViReTs). [...]
2022 - 10.1111/joim.13484
Journal of Internal Medicine, Vol. 292 (march 2022) , p. 308-320
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3.
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20 p, 11.4 MB |
Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections
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Romero-Martín, Luis (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olivella, Mireia (Universitat de Vic - Universitat Central de Catalunya) ;
Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sanchez, Jorge (Impacta) ;
Hartigan-O'Connor, Dennis (University of California) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
The contribution of the HLA-E/NKG2X axis in NK-mediated control of HIV infection remains unclear. We have studied the relationship between HLA-E expression and phenotypical as well as functional characteristics of NK cells, in the context of chronic HIV infection and in an in vitro model of acute infection. [...]
2022 - 10.3389/fimmu.2022.1027855
Frontiers in immunology, Vol. 13 (november 2022)
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4.
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17 p, 3.2 MB |
Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction
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Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano Montero, Anuska (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Kawana-Tachikawa, Ai (National Institute of Infectious Diseases (Tokio)) ;
Prats, Anna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Zalacain, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ;
Kobayashi-Ishihara, Mie (Universitat Pompeu Fabra) ;
Oriol-Tordera, Bruna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Peña, Ruth (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Silva-Arrieta, Sandra (Silva-Arrieta, Sandra) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sanchez, Jorge (Centro de Investigaciones Tecnologicas Biomedicas y Medioambientales (Perú)) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hartigan-O'Connor, Dennis (University of California. Department of Medical Microbiology and Immunology) ;
Wyss-Coray, Tony (Stanford University School of Medicine. Department of Neurology and Neurological Science) ;
Meyerhans, Andreas (University of Gothenburg. Department of Infectious Diseases) ;
Gisslén, Magnus (University of Gothenburg. Department of Infectious Diseases) ;
Price, Richard W. (University of California San Francisco. Department of Neurology) ;
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Muñoz-Moreno, José Antonio (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The implementation and access to combined antiretroviral treatment (cART) have dramatically improved the quality of life of people living with HIV (PLWH). However, some comorbidities, such as neurological disorders associated with HIV infection still represent a serious clinical challenge. [...]
2023 - 10.1128/jvi.01655-22
Journal of Virology, Vol. 97 (January 2023)
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5.
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19 p, 1.9 MB |
Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals
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Ainsua-Enrich, Erola (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pedreño-López, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bracke Manzanares, Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Avila-Nieto, Carlos (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodríguez de la Concepción, María Luisa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pradenas, Edwards (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Trinité, Benjamin (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marfil, Sílvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Miranda, Cristina (Fight AIDS Foundation, Badalona) ;
González, Sandra (Fight AIDS Foundation, Badalona) ;
Toledo, Ruth (Fight AIDS Foundation, Badalona) ;
Font, Marta (Fight AIDS Foundation, Badalona) ;
Benet, Susana (Fight AIDS Foundation, Badalona) ;
Escribà, Tuixent (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Jiménez-Moyano, Esther (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Peña, Ruth (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vergara-Alert, Júlia (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Massanella, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Benítez Díaz, Rosa María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Romero, Alba (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Molina-Morant, Daniel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mateu, Lourdes (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Pedro-Botet, Maria Luisa (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Mass vaccination campaigns reduced COVID-19 incidence and severity. Here, we evaluated the immune responses developed in SARS-CoV-2-uninfected patients with predominantly antibody-deficiencies (PAD) after three mRNA-1273 vaccine doses. [...]
2022 - 10.1016/j.isci.2022.105455
iScience, october 2022
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6.
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19 p, 3.7 MB |
Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome
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Oriol-Tordera, Bruna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Esteve-Codina, Anna (Universitat Pompeu Fabra) ;
Berdasco, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rosás-Umbert, Míriam (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Gonçalves, Elena (Sorbonne Université) ;
Duran-Castells, Clara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (CIBERINFEC) ;
Tolstrup, Martin (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Søgaard, Ole S. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol) ;
Martínez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Hanke, Tomáš (Kumamoto University) ;
Combadiere, Behazine (Sorbonne Université) ;
Paredes, Roger (Institut Germans Trias i Pujol) ;
Hartigan-O'Connor, Dennis (UC Davis School of Medicine(Estats Units d'Amèrica)) ;
Esteller, M (Universitat de Barcelona. Departament de Ciències Fisiològiques II) ;
Meulbroek, Michael (Projecte dels NOMS-Hispanosida, BCN Checkpoint (Barcelona)) ;
Calle, M. Luz (Universitat de Vic) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Moltó, José (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
European Commission. Horizon 2020 $a The BCN02-trial combined therapeutic vaccination with a viral latency reversing agent (romidepsin, RMD) in HIV-1-infected individuals and included a monitored antiretroviral pause (MAP) as an efficacy read-out identifying individuals with an early or late (< or > 4weeks) viral-rebound. [...]
2022 - 10.1016/j.ebiom.2022.103956
EBioMedicine, Vol. 78 (march 2022)
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7.
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15 p, 4.3 MB |
Gut microbiome signatures linked to HIV-1 reservoir size and viremia control
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Borgognone, Alessandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Noguera-Julian, Marc (Universitat de Vic - Universitat Central de Catalunya) ;
Oriol, Bruna (Universitat Autònoma de Barcelona) ;
Noël-Romas, Laura (University of Manitoba) ;
Ruiz-Riol, Marta (CIBERINFEC (Madrid)) ;
Guillén, Yolanda (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Parera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Casadellà, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Duran-Castells, Clara (Universitat Autònoma de Barcelona) ;
Puertas, Maria C. (CIBERINFEC, Madrid, Spain) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
De Leon, Marlon (Case Western Reserve University) ;
Knodel, Samantha (University of Manitoba) ;
Birse, Kenzie (University of Manitoba) ;
Manzardo, Christian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Miró, José M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Moltó, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Burgener, Adam (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ;
Paredes, Roger (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The potential role of the gut microbiome as a predictor of immune-mediated HIV-1 control in the absence of antiretroviral therapy (ART) is still unknown. In the BCN02 clinical trial, which combined the MVA. [...]
2022 - 10.1186/s40168-022-01247-6
Microbiome, Vol. 10 (april 2022)
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8.
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9 p, 1.3 MB |
Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
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Prats, Anna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez-Zalacaín, Ignacio (Universitat de Barcelona. Departament de Ciències Clíniques) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Garolera, Maite (Universitat de Barcelona) ;
Domènech-Puigcerver, Sira (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Meulbroek, Michael (Projecte dels NOMS - Hispanosida, BCN Checkpoint) ;
Chamorro, Anna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fumaz, Carmina R. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ferrer, Maria Jose (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Soriano-Mas, Carles (Institut d'Investigació Biomèdica de Bellvitge) ;
Muñoz-Moreno, Jose A. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Integrase strand transfer inhibitors (INSTI) are a main component of the current antiretroviral regimens recommended for treatment of HIV infection. However, little is known about the impact of INSTI on neurocognition and neuroimaging. [...]
2021 - 10.1038/s41598-021-90678-6
Scientific reports, Vol. 11 (may 2021)
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9.
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11 p, 844.7 KB |
Effect of Maraviroc Intensification on HIV-1-Specific T Cell Immunity in Recently HIV-1-Infected Individuals
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Kawana-Tachikawa, Ai (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llibre, Josep M.. (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Bravo, Isabel (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Escrig, Roser (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Puig, Jordi (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Manzardo, Christian (Hospital Clínic i Provincial de Barcelona) ;
Miro, Jose M. (Hospital Clínic i Provincial de Barcelona) ;
Iwamoto, Aikichi (The Institute of Medical Science, The University of Tokyo, Japan) ;
Pozniak, Anton L. (HIV/GUM Department, Chelsea and Westminster Hospital, London, United Kingdom) ;
Gatell, Jose M. (Hospital Clínic i Provincial de Barcelona) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Brander, Christian (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
The effect of maraviroc on the maintenance and the function of HIV-1-specific T cell responses remains unknown. Subjects recently infected with HIV-1 were randomized to receive anti-retroviral treatment with or without maraviroc intensification for 48 weeks, and were monitored up to week 60. [...]
2014 - 10.1371/journal.pone.0087334
PloS one, Vol. 9 (january 2014)
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10.
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13 p, 1.1 MB |
Altered Response Hierarchy and Increased T-Cell Breadth upon HIV-1 Conserved Element DNA Vaccination in Macaques
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Kulkarni, Viraj (National Cancer Institute, Frederick, Maryland, United States of America) ;
Valentin, Antonio (National Cancer Institute, Frederick, Maryland, United States of America) ;
Rosati, Margherita (National Cancer Institute, Frederick, Maryland, United States of America) ;
Alicea, Cándido (National Cancer Institute, Frederick, Maryland, United States of America) ;
Singh, Ashish K. (National Cancer Institute, Frederick, Maryland, United States of America) ;
Jalah, Rashmi (National Cancer Institute, Frederick, Maryland, United States of America) ;
Broderick, Kate E. (Inovio Pharmaceuticals, Inc., Blue Bell, Pennsylvania, United States of America) ;
Sardesai, Niranjan Y. (Inovio Pharmaceuticals, Inc., Blue Bell, Pennsylvania, United States of America) ;
Le Gall, Sylvie (Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rolland, Morgane (University of Washington, Seattle, Washington, United States of America) ;
Mullins, James I. (University of Washington, Seattle, Washington, United States of America) ;
Pavlakis, George N. (National Cancer Institute, Frederick, Maryland, United States of America) ;
Felber, Barbara K. (National Cancer Institute, Frederick, Maryland, United States of America) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
HIV sequence diversity and potential decoy epitopes are hurdles in the development of an effective AIDS vaccine. A DNA vaccine candidate comprising of highly conserved p24 gag elements (CE) induced robust immunity in all 10 vaccinated macaques, whereas full-length gag DNA vaccination elicited responses to these conserved elements in only 5 of 11 animals, targeting fewer CE per animal. [...]
2014 - 10.1371/journal.pone.0086254
PloS one, Vol. 9 (january 2014)
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