Depósito Digital de Documentos de la UAB Encontrados 8 registros  La búsqueda tardó 0.01 segundos. 
1.
40 p, 5.5 MB Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB and Serotonin 5-HT Receptors / Viñals, Xavier (Universitat Pompeu Fabra. Laboratori de Neurofarmacologia) ; Moreno, Estefanía (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Lanfumey, Laurence (Université Paris Descartes. Institut de Psychiatrie et Neurosciences de Paris (UMR 894)) ; Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Pastor, Antoni (IMIM-Institut Hospital del Mar d'Investigacions Médiques. Integrative Pharmacology and Systems Neuroscience) ; de La Torre, Rafael (IMIM-Institut Hospital del Mar d'Investigacions Médiques. Integrative Pharmacology and Systems Neuroscience) ; Gasperini, Paola (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ; Navarro, Gemma (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Howell, Lesley A. (University of East Anglia. School of Pharmacy (United Kingdom)) ; Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Lluís, Carmen (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Canela, Enric I. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; McCormick, Peter J. (University of East Anglia. School of Pharmacy (United Kingdom)) ; Maldonado, Rafael (Universitat Pompeu Fabra. Laboratori de Neurofarmacologia) ; Robledo, Patricia (IMIM-Institut Hospital del Mar d'Investigacions Médiques. Integrative Pharmacology and Systems Neuroscience)
Activation of cannabinoid CB1 receptors (CBR) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis users that constitute important drawbacks for the use of cannabinoids as therapeutic agents. [...]
2015 - 10.1371/journal.pbio.1002194
PLoS Biology, Vol. 13, Num. 7 (July 2015) , art. e1002194  
2.
9 p, 627.3 KB What makes a protein sequence a prion ? / Sabaté, Raimon (Universitat de Barcelona. Departament de Fisicoquímica) ; Rousseau, Frederic (KU Leuven. Department for Cellular and Molecular Medicine) ; Schymkowitz, Joost (KU Leuven. Departement for Cellular and Molecular Medicine) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Typical amyloid diseases such as Alzheimer's and Parkinson's were thought to exclusively result from de novo aggregation, but recently it was shown that amyloids formed in one cell can cross-seed aggregation in other cells, following a prion-like mechanism. [...]
2015 - 10.1371/journal.pcbi.1004013
PLoS computational biology, Vol. 11, Issue 1 (Jan. 2015) , art. e1004013  
3.
15 p, 1.4 MB Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1 / Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Lorizate, Maier (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Contreras, F. Xabier (Heidelberg University Biochemistry Center (BZH), Heidelberg) ; Rodríguez Plata, María T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Glass, Bärbel (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Casas, Josefina (Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC)/CSIC, Barcelona, Spain) ; Fabriàs, Gemma (Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC)/CSIC, Barcelona, Spain) ; Kräusslich, Hans Georg (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Martínez Picado, Javier (Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain)
An accessible sialyllactose moiety on viral membrane gangliosides is shown to be essential for HIV-1 uptake into mature dendritic cells, thereby promoting viral transfer and infection of bystander CD4+ T lymphocytes. [...]
2012 - 10.1371/journal.pbio.1001315
PLoS Biology, Vol. 10 (april 2012)  
4.
25 p, 6.5 MB ATPase-Dependent Control of the Mms21 SUMO Ligase during DNA Repair / Bermúdez-López, Marcelino (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Pociño-Merino, Irene (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Sánchez, Humberto (Erasmus Medical Center, Department of Genetics and Radiation Oncology, Rotterdam) ; Bueno, Andrés (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Guasch, Clàudia (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Almedawar, Seba (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Bru-Virgili, Sergi (Universitat Autònoma de Barcelona, Dept. de Bioquímica i Biologia Molecular) ; Garí, Eloi (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Wyman, Claire (Erasmus Medical Center, Department of Genetics and Radiation Oncology, Rotterdam) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Colomina, Neus (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques) ; Torres-Rosell, Jordi (Universitat de Lleida. Departament de Ciències Mèdiques Bàsiques)
Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid disjunction. [...]
2015 - 10.1371/journal.pbio.1002089
PLoS biology, Vol. 13 Issue 3 (march 2015) , p. 1-25  
5.
11 p, 7.8 MB Understanding the molecular determinants driving the immunological specificity of the protective pilus 2a backbone protein of Group B Streptococcus / Nuccitelli, Annalisa (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ; Rinaudo, C. Daniela (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ; Brogioni, Barbara (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ; Cozzi, Roberta (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ; Ferrer Navarro, Mario (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yero Corona, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Telford, John L. (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ; Grandi, Guido (Novartis Vaccines and Diagnostics (Siena, Itàlia)) ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Zacharias, Martin (Technical University Munich. Physics Department) ; Maione, Domenico (Novartis Vaccines and Diagnostics (Siena, Itàlia))
The pilus 2a backbone protein (BP-2a) is one of the most structurally and functionally characterized components of a potential vaccine formulation against Group B Streptococcus. It is characterized by six main immunologically distinct allelic variants, each inducing variant-specific protection. [...]
2013 - 10.1371/journal.pcbi.1003115
PLOS Computational Biology, Vol. 9, Issue 6 (June 2013) , p. e1003115  
6.
11 p, 609.4 KB Potassium starvation in yeast : mechanisms of homeostasis revealed by mathematical modeling / Kahm, Matthias (University of Applied Sciences. Department of Mathematics and Technology (Koblenz, Alemanya)) ; Navarrete, Clara (Universidad de Córdoba. Departmento de Microbiologia) ; Llopis Torregrosa, Vicent (Instituto de Biologia Molecular y Celular de Plantas (València, Espanya)) ; Herrera, Rito (Universidad de Córdoba. Departmento de Microbiologia) ; Barreto, Lina (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Yenush, Lynne (Instituto de Biologia Molecular y Celular de Plantas (València, Espanya)) ; Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ramos, José (Universidad de Córdoba. Departmento de Microbiologia) ; Kschischo, Maik (University of Applied Sciences. Department of Mathematics and Technology (Koblenz, Alemanya))
The intrinsic ability of cells to adapt to a wide range of environmental conditions is a fundamental process required for survival. Potassium is the most abundant cation in living cells and is required for essential cellular processes, including the regulation of cell volume, pH and protein synthesis. [...]
2012 - 10.1371/journal.pcbi.1002548
PLOS Computational Biology, Vol. 8, Issue 6 (June 2012) , p. e1002548  
7.
16 p, 1.6 MB Amyloidogenic regions and interaction surfaces overlap in globular proteins related to conformational diseases / Castillo Cano, Virginia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Protein aggregation underlies a wide range of human disorders. The polypeptides involved in these pathologies might be intrinsically unstructured or display a defined 3D-structure. Little is known about how globular proteins aggregate into toxic assemblies under physiological conditions, where they display an initially folded conformation. [...]
2009 - 10.1371/journal.pcbi.1000476
PLOS Computational Biology, Vol. 5, Issue 8 (August 2009) , p. e1000476  
8.
15 p, 1.1 MB Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland / González, Sergio (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Moreno Delgado, David (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Moreno, Estefanía (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Pérez-Capote, Kamil (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Franco, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Mallol, Josefa (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Cortés, Antoni (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Casadó, Vicent (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Lluís, Carme (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ortiz de Pablo, Jordi (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ferré, Sergi (National Institute on Drug Abuse (Baltimore, Estats Units d'Amèrica)) ; Canela, Enric (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; McCormick Peter J. (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular)
The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and release. [...]
2012 - 10.1371/journal.pbio.1001347
PLoS biology, Vol. 10 Issue 6 (June 2012) , p. e1001347  

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