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11.
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16 p, 3.7 MB |
Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
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Pitrez, Patricia R. (University of Coimbra) ;
Estronca, Luís (University of Coimbra) ;
Monteiro, Luís Miguel (University of Coimbra) ;
Colell, Guillem (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vazão, Helena (University of Coimbra) ;
Santinha, Deolinda (University of Coimbra) ;
Harhouri, Karim (Aix Marseille Univ) ;
Thornton, Daniel (University of Liverpool) ;
Navarro, Claire (Progelife (França)) ;
Egesipe, Anne-Laure (Institute for Stem Cell Therapy and Exploration of Monogenic Diseases) ;
Carvalho, Tânia (Universidade de Lisboa) ;
Dos Santos, Rodrigo L. (Cambridge Science Park) ;
Lévy, Nicolas (La Timone Children's Hospital) ;
Smith, James C. (Francis Crick Institute) ;
de Magalhaes, Joao Pedro (University of Liverpool. Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease) ;
Ori, Alessandro (Leibniz Institute on Aging) ;
Bernardo, Andreia (Francis Crick Institute) ;
De Sandre-Giovannoli, Annachiara (CRB Assistance Publique des Hôpitaux de Marseille) ;
Nissan, Xavier (Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (França)) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferreira, Lino (University of Coimbra) ;
Universitat Autònoma de Barcelona
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS individuals, although the reason for such vulnerability remains poorly understood. [...]
2020 -  10.1038/s41467-020-17901-2
Nature communications, Vol. 11 (august 2020)
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12.
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11 p, 887.1 KB |
Major Bleeding Predictors in Patients with Left Atrial Appendage Closure : The Iberian Registry II
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López-Mínguez, José Ramón (Hospital Universitario de Badajoz) ;
Nogales-Asensio, Juan Manuel (Hospital Universitario de Badajoz) ;
Infante De Oliveira, Eduardo (Hospital de Santa María, 1649-028 Lisbon, Portugal) ;
Santos, Lino (Centro Hospitalario de Vila Nova de Gaia, 4430-999 Vila Nova de Gaia Oporto, Portugal) ;
Ruiz-Salmerón, Rafael (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Arzamendi, Dabit (Institut d'Investigació Biomèdica Sant Pau) ;
Costa, Marco (Centro Hospitalar e Universitário de Coimbra, 3004-561 Coimbra, Portugal) ;
Gutiérrez-García, Hipólito (Hospital Clínico Universitario de Valladolid) ;
Fernández-Díaz, Jose Antonio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Freixa, Xavier (Hospital Clínic i Provincial de Barcelona) ;
Cruz-González, Ignacio (Hospital Universitario de Salamanca) ;
Moreno, Raúl (Hospital Universitario La Paz (Madrid)) ;
Íñiguez-Romo, Andrés (Hospital Álvaro Cunqueiro (Vigo)) ;
Alfonso, Fernando (Hospital Universitario de la Princesa (Madrid)) ;
Universitat Autònoma de Barcelona
Introduction and objective: Major bleeding events in patients undergoing left atrial appendage closure (LAAC) range from 2. 2 to 10. 3 per 100 patient-years in different series. This study aimed to clarify the bleeding predictive factors that could influence these differences. [...]
2020 - 10.3390/jcm9072295
Journal of clinical medicine, Vol. 9 (july 2020)
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13.
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15 p, 3.0 MB |
Simple Measurement of IgA Predicts Immunity and Mortality in Ataxia-Telangiectasia
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Zielen, Stefan (Goethe University. Division of Allergology, Pulmonology and Cystic Fibrosis) ;
Duecker, Ruth Pia (Goethe University. Division of Allergology, Pulmonology and Cystic Fibrosis) ;
Woelke, Sandra (Goethe University. Division of Allergology, Pulmonology and Cystic Fibrosis) ;
Donath, Helena (Goethe University. Division of Allergology, Pulmonology and Cystic Fibrosis) ;
Bakhtiar, Shahrzad (Goethe University. Division for Stem Cell Transplantation, Immunology and Intensive Care Unit) ;
Buecker, Aileen (Goethe University. Division of Allergology, Pulmonology and Cystic Fibrosis) ;
Kreyenberg, Hermann (Goethe University. Division for Stem Cell Transplantation, Immunology and Intensive Care Unit) ;
Huenecke, Sabine (Goethe University. Division for Stem Cell Transplantation, Immunology and Intensive Care Unit) ;
Bader, Peter (Goethe University. Division for Stem Cell Transplantation, Immunology and Intensive Care Unit) ;
Mahlaoui, Nizar (Necker Children's University Hospital. Pediatric Immunology-Hematology and Rheumatology Unit) ;
Ehl, Stephan (University of Freiburg. Institute for Immunodeficiency) ;
El-Helou, Sabine M. (Hannover Medical School. Department of Rheumatology and Immunology) ;
Pietrucha, Barbara (The Children's Memorial Health Institute. Department of Immunology) ;
Plebani, Alessandro (University of Brescia. Department of Clinical and Experimental Sciences) ;
van der Flier, Michiel (Radboud University Medical Center. Section Pediatric Infectious Diseases) ;
van Aerde, Koen (Radboud University Medical Center. Department of Pediatrics) ;
Kilic, Sara S. (Uludag University. Department of Pediatric Immunology and Rheumatology) ;
Reda, Shereen M. (Ain Shams University. Department of Pediatrics) ;
Kostyuchenko, Larysa (Western Ukrainian Specialized Children's Medical Centre) ;
McDermott, Elizabeth (Nottingham University Hospitals NHS Trust (Regne Unit)) ;
Galal, Nermeen (Cairo University Specialized Pediatric Hospital. Department of Pediatrics) ;
Pignata, Claudio (Federico II University. Department of Translational Medical Sciences) ;
Santos-Pérez, Juan Luis (Hospital Universitario Virgen de las Nieves (Granada)) ;
Laws, Hans-Juergen (Heinrich-Heine University. Department of Pediatric Oncology, Hematology and Clinical Immunology) ;
Niehues, Tim (Centre for Child and Adolescent Health (Krefeld, Germany)) ;
Kutukculer, Necil (Ege University. Department of Pediatric Immunology) ;
Seidel, Markus G. (Medical University Graz. Department of Pediatrics and Adolescent Medicine) ;
Marques, Laura (Porto Hospital Center. Pediatric Department) ;
Ciznar, Peter (Comenius University in Bratislava. Pediatric Department) ;
Edgar, John David M. (The Royal Hospitals & Queen's University) ;
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
von Bernuth, Horst (Charité - Universitätsmedizin Berlin) ;
Krueger, Renate (Charité - Universitätsmedizin Berlin) ;
Meyts, Isabelle (University Hospitals Leuven (Bèlgica)) ;
Baumann, Ulrich (Hannover Medical School. Department of Paediatric Pulmonology, Allergy and Neonatology) ;
Kanariou, Maria ("Aghia Sophia" Children's Hospital. Department of Immunology and Histocompatibility) ;
Grimbacher, Bodo (Albert-Ludwigs University) ;
Hauck, Fabian (Ludwig-Maximilians-University Munich. Department of Pediatrics) ;
Graf, Dagmar (MVZ Dr. Reising-Ackermann Und Kollegen (Leipzig, Germany)) ;
Granado, Luis Ignacio Gonzalez (Universidad Complutense de Madrid) ;
Prader, Seraina (University Children's Hospital Zurich. Division of Immunology and Children's Research Center) ;
Reisli, Ismail (Necmettin Erbakan University. Department of Pediatrics) ;
Slatter, Mary (Newcastle University. Primary Immunodeficiency Group, Paediatric Immunology and Haematopoietic Stem Cell Transplantation) ;
Rodríguez-Gallego, Carlos (University Fernando Pessoa Canarias. Department of Immunology) ;
Arkwright, Peter D. (University of Manchester. Lydia Becker Institute of Immunology and Inflammation) ;
Bethune, Claire (University Hospitals Plymouth NHS Trust (Regne Unit)) ;
Deripapa, Elena (National Medical Research Center of Pediatric Hematology, Oncology and Immunology (Moscow, Russia)) ;
Sharapova, Svetlana O. (Belarusian Research Center for Pediatric Oncology, Hematology and Immunology. Research Department) ;
Lehmberg, Kai (University Medical Center Hamburg-Eppendorf. Division for Pediatric Stem Cell Transplantation and Immunology) ;
Davies, E. Graham (Great Ormond Street Hospital for Children (Londres)) ;
Schuetz, Catharina (Technische Universität Dresden. Department of Pediatrics) ;
Kindle, Gerhard (University of Freiburg. FREEZE Biobank) ;
Schubert, Ralf (Goethe University. Division of Allergology, Pulmonology and Cystic Fibrosis) ;
Universitat Autònoma de Barcelona
Patients with ataxia-telangiectasia (A-T) sufer from progressive cerebellar ataxia, immunodefciency, respiratory failure, and cancer susceptibility. From a clinical point of view, A-T patients with IgA defciency show more symptoms and may have a poorer prognosis. [...]
2021 - 10.1007/s10875-021-01090-8
Journal of Clinical Immunology, Vol. 41 (september 2021) , p. 1878-1892
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14.
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10 p, 1.6 MB |
Quantitative assessment of the vertebral pneumaticity in an anhanguerid pterosaur using micro-CT scanning
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Buchmann, Richard (Universidade Federal do Estado do Rio de Janeiro. Departamento de Zoologia. Laboratório de Mastozoologia) ;
Holgado, Borja (Institut Català de Paleontologia Miquel Crusafont) ;
Sobral, Gabriela (Staatliches Museum für Naturkunde in Stuttgart) ;
dos Santos Avilla, Leonardo (Universidade Federal do Estado do Rio de Janeiro. Departamento de Zoologia. Laboratório de Mastozoologia) ;
Rodrigues, Taissa (Universidade Federal do Espírito Santo (Brazil). Departamento de Ciências Biológicas. Laboratório de Paleontologia)
Research on the postcranial skeletal pneumaticity in pterosaurs is common in the literature, but most studies present only qualitative assessments. When quantitative, they are done on isolated bones. [...]
2021 - 10.1038/s41598-021-97856-6
Scientific reports, Vol. 11 (September 2021) , art. 18718
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15.
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24 p, 344.7 KB |
Conscientização e serviços ambientalmente adequados
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Santos, Patrick Leite (Universidade Federal de Uberlândia. Instituto de Economia e Relações Internacionais) ;
Saiani, Carlos Cesar Santejo (Universidade Federal de Uberlândia. Instituto de Economia e Relações Internacionais) ;
Vieira, Ednando Batista (Universidade Estadual de Goiás (Brasil)) ;
Piorski, Cesar Ricardo Leite (Universidade Federal de Uberlândia. Instituto de Economia e Relações Internacionais)
A educação (conhecimento) é um condicionante da conscientização ambiental, influenciando a demanda e a oferta de produtos menos degradantes, como o acesso ambientalmente mais adequado a saneamento básico. [...]
La educación (conocimiento) es una condición para la conciencia ambiental, que influye en la demanda y oferta de productos menos degradantes, como un acceso más ecológico al saneamiento básico. El objetivo de este estudio es evaluar esta hipótesis utilizando el acceso a la información a través de los medios de comunicación (conocimiento informal) en conjunto con la instrucción (conocimiento formal) como proxy para la sensibilización en las investigaciones de los determinantes del acceso a los servicios de saneamiento en Brasil, que todavía están, en general, lejos de ser universalizados. [...]
Education (knowledge) is a condition for environmental awareness that influences the demand and supply of less degrading products, such as more environmentally friendly access to basic sanitation. The aim of this study is to evaluate this hypothesis using access to information through means of communication (informal knowledge) together with instruction (formal knowledge) as proxies for environmental awareness in analyzes of determinants of access to sanitation services in Brazil, which in general, they are still far from universal. [...]
2021
Revibec : revista de la Red Iberoamericana de Economia Ecológica, Vol. 34 (2021) , p. 1-24 (Articles)
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16.
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22 p, 5.2 MB |
Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment
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Urdinguio, Rocío G. (Instituto de Oncología de Asturias-IUOPA) ;
López, Virginia (Centro de Investigación en Nanociencia y Nanotecnología (Oviedo, Astúries)) ;
Fernández Bayón, Gustavo (Instituto de Oncología de Asturias-IUOPA) ;
Díaz de la Guardia, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sierra, Marta I. (Instituto de Oncología de Asturias-IUOPA) ;
García-Toraño, Estela (Instituto de Oncología de Asturias-IUOPA) ;
Pérez, Raúl F. (Instituto de Oncología de Asturias-IUOPA) ;
García, María G. (Instituto de Oncología de Asturias-IUOPA) ;
Carella, Antonella (Instituto de Oncología de Asturias-IUOPA) ;
Pruneda, Patricia C. (Instituto de Oncología de Asturias-IUOPA) ;
Prieto, Cristina (Instituto de Oncología de Asturias-IUOPA) ;
Dmitrijeva, Marija (Instituto de Oncología de Asturias-IUOPA) ;
Santamarina-Ojeda, Pablo (Instituto de Oncología de Asturias-IUOPA) ;
Belmonte, Thalia (Instituto de Oncología de Asturias-IUOPA) ;
Mangas, Cristina (Instituto de Oncología de Asturias-IUOPA) ;
Diaconu, Elena (Instituto de Oncología de Asturias-IUOPA) ;
Ferrero, Cecilia (Instituto de Oncología de Asturias-IUOPA) ;
Tejedor, Juan Ramón (Instituto de Oncología de Asturias-IUOPA) ;
Fernandez-Morera, Juan Luis (Instituto de Oncología de Asturias-IUOPA) ;
Bravo, Cristina (Instituto de Oncología de Asturias-IUOPA) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sanjuan-Pla, Alejandra (Instituto de Investigación Sanitaria La Fe) ;
Rodríguez López, Ramón María (Hospital Universitario Central de Asturias) ;
Suárez-Álvarez, Beatriz (Hospital Universitario Central de Asturias) ;
López-Larrea, Carlos (Hospital Universitario Central de Asturias) ;
Bernal, Teresa (Hospital Universitario Central de Asturias) ;
Colado, Enrique (Hospital Universitario Central de Asturias) ;
Balbín, Milagros (Hospital Universitario Central de Asturias) ;
García-Suarez, Olivia (Universidad de Oviedo. Departamento de Morfología y Biología Celular) ;
Chiara, María Dolores (Hospital Universitario Central de Asturias) ;
Sáenz De Santa María, Inés (Hospital Universitario Central de Asturias) ;
Rodríguez, Francisco (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular) ;
Pando-Sandoval, Ana (Hospital Universitario Central de Asturias) ;
Rodrigo-Sáez, Luis (Hospital Universitario Central de Asturias) ;
Santos, Laura. (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Salas, Ana (Universidad de Oviedo. Servicio de Citometría) ;
Vallejo-Díaz, Jesús (Centro Nacional de Biotecnología (CNB-CSIC)) ;
Carrera, Ana C. (Centro Nacional de Biotecnología (CNB-CSIC)) ;
Rico, Daniel (Newcastle University. Institute of Cellular Medicine) ;
Hernández-López, Inmaculada (Newcastle University. Institute of Cellular Medicine) ;
Vayá, Amparo (Hospital Universitari i Politècnic La Fe (València)) ;
Ricart, José María (Quirón Clinic. Dermatology Service) ;
Seto, Edward (George Washington University Cancer Center) ;
Sima, Núria (Institut d'Investigació Biomèdica de Bellvitge) ;
Vaquero, Alejandro (Institut d'Investigació Biomèdica de Bellvitge) ;
Valledor, Luís (Universidad de Oviedo. Facultad de Biología) ;
Cañal Villanueva, María Jesús Fátima (Universidad de Oviedo. Facultad de Biología) ;
Pisano, David (Centro Nacional de Investigaciones Oncológicas) ;
Graña-Castro, Osvaldo (Centro Nacional de Investigaciones Oncológicas) ;
Thomas, Tim (University of Melbourne. Department of Medical Biology (Austràlia)) ;
Voss, Anne Kathrin (University of Melbourne. Department of Medical Biology (Austràlia)) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villar-Garea, Ana (University of Regensburg) ;
Deutzmann, Rainer (University of Regensburg) ;
Fernández, Agustín F (Instituto de Oncología de Asturias-IUOPA) ;
Fraga, Mario F. (Centro de Investigación en Nanociencia y Nanotecnología (Oviedo, Astúries)) ;
Universitat Autònoma de Barcelona
Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. [...]
2019 - 10.1093/nar/gkz195
Nucleic acids research, Vol. 47 Núm. 10 (april 2019) , p. 5016-5037
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17.
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7 p, 1.2 MB |
Immune reactivity to Trypanosoma cruzi chimeric proteins for Chagas disease diagnosis in immigrants living in a non-endemic setting
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Dopico, Eva (Institut Català de la Salut) ;
Del-Rei, Rodrigo Pimenta (Faculty of Technology and Sciences of Bahia) ;
Espinoza, Bertha (Universidad Nacional Autónoma de México. Instituto de Investigaciones Biomédicas) ;
Ubillos, Itziar (Institut Català de la Salut) ;
Zanchin, Nilson Ivo Tonin (Oswaldo Cruz Foundation. Carlos Chagas Institute) ;
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron) ;
Moure García, Zaira (Hospital Universitari Vall d'Hebron) ;
Celedon, Paola Alejandra Fiorani (Molecular Biology Institute of Paraná) ;
Souza, Wayner Vieira (Oswaldo Cruz Foundation. Aggeu Magalhães Institute) ;
da Silva, Edimilson Domingos (Oswaldo Cruz Foundation. Immunobiological Technology Institute) ;
Gomes, Yara Miranda (Oswaldo Cruz Foundation. Aggeu Magalhães Institute) ;
Santos, Fred Luciano Neves (Oswaldo Cruz Foundation. Gonçalo Moniz Institute) ;
Universitat Autònoma de Barcelona
Chronic Chagas Disease (CD) diagnosis is based on serological methods employing crude, semipurified or recombinant antigens, which may result in low sensitivity or cross-reactivity. To reduce these restrictions, we developed a strategy involving use of molecules containing repetitive fragments of Trypanosoma cruzi conserved proteins. [...]
2019 - 10.1186/s12879-019-3872-z
BMC Infectious diseases, Vol. 19 (march 2019)
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18.
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0 p, 658.9 KB |
Expanding the Clinical and Genetic Spectra of Primary Immunodeficiency-Related Disorders With Clinical Exome Sequencing : Expected and Unexpected Findings
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Rudilla, Francesc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Franco-Jarava, Clara (Jeffrey Model Foundation Excellence Center) ;
Martínez Gallo, Mónica (Jeffrey Model Foundation Excellence Center) ;
Garcia-Prat, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martín-Nalda, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rivière, Jacques (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Aguiló-Cucurull, Aina (Jeffrey Model Foundation Excellence Center) ;
Mongay, Laura (Banc de Sang i Teixits) ;
Vidal, Francisco (Instituto de Salud Carlos III) ;
Solanich, Xavier (Hospital Universitari de Bellvitge) ;
Irastorza, Iñaki (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Santos-Pérez, Juan Luis (Hospital Universitario Virgen de las Nieves (Granada)) ;
Tercedor Sánchez, Jesús (Hospital Universitario Virgen de las Nieves (Granada)) ;
Cusco, Ivon (Hospital Universitari Vall d'Hebron) ;
Serra, Clara (Hospital Universitari Vall d'Hebron) ;
Baz-Redón, Noelia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández Cancio, Mónica (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Carreras, Carmen (Hospital Universitari i Politècnic La Fe (València)) ;
Vagace, Manuel (Complejo Hospitalario Universitario de Badajoz) ;
García-Patos Briones, Vicente (Hospital Universitari Vall d'Hebron) ;
Pujol-Borrell, Ricardo (Jeffrey Model Foundation Excellence Center) ;
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Primary immunodeficiencies (PIDs) refer to a clinically, immunologically, and genetically heterogeneous group of over 350 disorders affecting development or function of the immune system. The increasing use of next-generation sequencing (NGS) technology has greatly facilitated identification of genetic defects in PID patients in daily clinical practice. [...]
2019 - 10.3389/fimmu.2019.02325
Frontiers in immunology, Vol. 10 (january 2019) , p. 2325
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19.
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168 p, 16.9 MB |
La ultrasonografia endobronquial en l'estudi del mediastí neoplàsic
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Serra Mitjà, Pere ;
Andreo García, Felipe, dir. ;
Sanz Santos, J. Luis 1969-, (José Luis) dir. ;
Ruiz Manzano, J., dir. ;
Universitat Autònoma de Barcelona.
Departament de Medicina
La present Tesi Doctoral es basa en tres articles que avaluen la idoneïtat de la ultrasonografia endobronquial amb punció aspirativa transbronquial (USEB-PATB) en l'estudi del mediastí neoplàsic, tant d'origen pulmonar com extra-pulmonar. [...]
The present doctoral thesis is based on three articles that evaluate the accuracy of endobronchial ultrasonography with transbronchial needle aspiration in the study of the mediastinum, both pulmonary and extra-pulmonary origin. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.
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20.
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4 p, 495.0 KB |
Complete laparoscopic excision of a hepatic cyst and omentopexy in a Persian cat
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Lafuente, Sofía (Universitat Autònoma de Barcelona. Fundació Hospital Clínic Veterinari) ;
Fresno, Laura (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Anselmi, Carlo (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Lloret Roca, Albert (Universitat Autònoma de Barcelona. Hospital Clínic Veterinari) ;
Espada, Yvonne (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Santos Benito, Laura (Universitat Autònoma de Barcelona. Fundació Hospital Clínic Veterinari)
Congenital or acquired hepatic cystic lesions in cats are a rare condition. Congenital hepatic cysts are often present as part of a systemic polycystic disease involving several organs. Most cats with hepatic cysts remain clinically normal for their lives, although some patients may show abdominal distension, vomiting, abdominal pain and jaundice. [...]
2018 - 10.1177/2055116918817631
Journal of feline medicine and surgery open reports, Vol. 4 (december 2018)
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