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12 p, 3.2 MB Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type / Karnezis, Anthony N (University of British Columbia. Department of Pathology and Laboratory Medicine) ; Wang, Yemin (University of British Columbia. Department of Pathology and Laboratory Medicine) ; Ramos, Pilar (Translational Genomics Research Institute (TGen). Division of Integrated Cancer Genomics) ; Hendricks, William PD (Translational Genomics Research Institute (TGen). Division of Integrated Cancer Genomics) ; Oliva, Esther (Massachusetts General Hospital. Department of Pathology) ; D'Angelo, Emanuela (Hospital de la Santa Creu i Sant Pau. Departament de Patologia) ; Prat, Jaime (Hospital de la Santa Creu i Sant Pau. Departament de Patologia) ; Nucci, Marisa R (Brigham and Women's Hospital. Department of Pathology) ; Nielsen, Torsten O (University of British Columbia. Department of Pathology and Laboratory Medicine) ; Chow, Christine (University of British Columbia. Genetic Pathology Evaluation Centre) ; Leung, Samuel (University of British Columbia. Genetic Pathology Evaluation Centre) ; Kommoss, Friedrich (Synlab MVZ Pathologie) ; Kommoss, Stefan (University Hospital of Tuebingen. Department of Obstetrics and Gynecology) ; Silva, Annacarolina (Harvard Medical School. The James Homer Wright Pathology Laboratories) ; Ronnett, Brigitte M (The Johns Hopkins Hospital. Department of Pathology) ; Rabban, Joseph T (University of California San Francisco. Department of Anatomic Pathology) ; Bowtell, David D (Peter MacCallum Cancer Centre) ; Weissman, Bernard E (University of North Carolina. Department of Pathology and Laboratory Medicine) ; Trent, Jeffrey M (Translational Genomics Research Institute (TGen). Division of Integrated Cancer Genomics) ; Gilks, C Blake (University of British Columbia. Department of Pathology and Laboratory Medicine) ; Huntsman, David G (University of British Columbia. Department of Pathology and Laboratory Medicine) ; Universitat Autònoma de Barcelona
Small cell carcinoma of the ovary, hypercalcaemic type () is a lethal and sometimes familial ovarian tumour of young women and children. We and others recently discovered that over 90% of harbour inactivating mutations in the chromatin remodelling gene with concomitant loss of its encoded protein (), one of two mutually exclusive of the / chromatin remodelling complex. [...]
2015 - 10.1002/path.4633
The Journal of Pathology, Vol. 238, Issue 3 (december 2015) , p. 389-400  

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