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23 p, 719.8 KB |
Increased Antimicrobial Resistance in a Novel CMY-54 AmpC-Type Enzyme with a GluLeu217-218 Insertion in the Ω-Loop
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Pérez-Llarena, Francisco José (Complejo Hospitalario Universitario de A Coruña) ;
Vázquez-Ucha, Juan Carlos (Complejo Hospitalario Universitario de A Coruña) ;
Kerff, Frédéric (Université de Liège) ;
Zamorano, Laura (Hospital Universitari Son Dureta (Palma de Mallorca, Balears)) ;
Miró, Elisenda (Institut d'Investigació Biomèdica Sant Pau) ;
Cabral, María Póvoa (Complejo Hospitalario Universitario de A Coruña) ;
Fleites, Ana (Universidad de Oviedo) ;
Lantero, Marta (Universidad de Oviedo) ;
Martínez-Martínez, Luis (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Oliver, Antonio (Hospital Universitari Son Dureta (Palma de Mallorca, Balears)) ;
Galleni, Moreno (Université de Liège) ;
Navarro Risueño, Ferran (Institut d'Investigació Biomèdica Sant Pau) ;
Beceiro, Alejandro (Complejo Hospitalario Universitario de A Coruña) ;
Bou, German (Complejo Hospitalario Universitario de A Coruña)
During a Spanish surveillance study, a natural variant of a CMY-type β-lactamase related to CMY-2 with a GluLeu217-218 insertion in the Ω-loop (designated CMY-54) was found to increase the minimum inhibitory concentractions to β-lactams in a clinical strain of Escherichia coli. [...]
2018 -  10.1089/mdr.2017.0017
Microbial Drug Resistance, Vol. 24, Issue 5 (June 2018) , p. 527-533
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17 p, 299.7 KB |
Characterization of the Genetic Environment of the blaVEB-4 Gene, Associated with a Transposable Region in a Proteus mirabilis Clinical Isolate
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Espinal, Paula (Institut d'Investigació Biomèdica Sant Pau) ;
Miró, Elisenda (Institut d'Investigació Biomèdica Sant Pau) ;
Ramoneda, Laia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Flores, Manel (Institut d'Investigació Biomèdica Sant Pau) ;
Rivera, Alba (Institut d'Investigació Biomèdica Sant Pau) ;
Coll Figa, Pedro (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Navarro Risueño, Ferran (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Proteus mirabilis is the second most common cause of urinary tract infections and is also an important cause of nosocomial infections. TEM-type and CTX-M-type extended-spectrum β-lactamases (ESBLs) are the most widely distributed in this bacterial species, but minor ESBLs such as the VEB-type have also been identified. [...]
2017 - 10.1089/mdr.2016.0262
Microbial Drug Resistance, Vol. 23, Issue 7 (October 2017) , p. 833-837
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12 p, 752.8 KB |
Lysosome-mediated chemoresistance in acute myeloid leukemia
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Cuesta-Casanovas, Laia (Universitat Autònoma de Barcelona) ;
Delgado-Martínez, Jennifer (Universitat de Barcelona) ;
Cornet-Masana, Josep Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Carbó, José María (Leukos Biotech) ;
Clément-Demange, Lise (Leukos Biotech (Barcelona)) ;
Risueño, Ruth M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Despite the outstanding advances in understanding the biology underlying the pathophysiology of acute myeloid leukemia (AML) and the promising preclinical data published lastly, AML treatment still relies on a classic chemotherapy regimen largely unchanged for the past five decades. [...]
2022 - 10.20517/cdr.2021.122
Cancer Drug Resistance, Vol. 5 Núm. 1 (2022) , p. 233-244
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5 p, 226.8 KB |
Impact of changes in the WHO's 2019 update of DDDs on the measurement of adult hospital antibacterial consumption in Catalonia (Spain), 2008-18
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Grau, Santiago (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Hernández Baeza, Sergi (VINCat Vigilància de les infeccions nosocomials als hospitals de Catalunya) ;
Limón, Enric (VINCat Vigilància de les infeccions nosocomials als hospitals de Catalunya) ;
Calbo Sebastián, Esther (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Horcajada, Juan Pablo (Hospital del Mar (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
In 2019 the WHO fully adopted new DDD values. The objective of this study is to analyse their impact on the measurement of consumption of antibacterials in hospitals participating in the Catalan Infection Control and Antimicrobial Stewardship National Program (VINCat-PROA) in Catalonia (Spain) between 2008 and 2018. [...]
2020 - 10.1093/jacamr/dlaa079
JAC-Antimicrobial Resistance, Vol. 2 (october 2020)
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10 p, 491.7 KB |
A Vaccine Against Group B Streptococcus : Recent Advances
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Carreras-Abad, Clara (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Ramkhelawon, Laxmee (St George's, University of London) ;
Heath, Paul T. (St George's, University of London) ;
Le Doare, Kirsty (St George's, University of London)
Group B streptococcus (GBS) causes a high burden of neonatal and infant disease globally. Implementing a vaccine for pregnant women is a promising strategy to prevent neonatal and infant GBS disease and has been identified as a priority by the World Health Organisation (WHO). [...]
2020 - 10.2147/IDR.S203454
Infection and drug resistance, Vol. 13 (april 2020) , p. 1263-1272
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Repurposing bioenergetic modulators against protozoan parasites responsible for tropical diseases
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Martínez-Flórez, Alba (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Galizzi, Melina (University of Georgia. Complex Carbohydrate Research Center) ;
Izquierdo, Luis 1936-2016 (Barcelona Institute for Global Health (ISGlobal)) ;
Bustamante, Juan M. (University of Georgia. Center for Tropical and Emerging Global Diseases.) ;
Rodriguez, Ana (New York University School of Medicine. Department of Microbiology) ;
Rodriguez, Fernando (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Rodríguez-Cortés, Alhelí (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Alberola, Jordi (Alberola i Domingo) (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Malaria, leishmaniasis and trypanosomiasis are arthropod-borne, parasitic diseases that constitute a major global health problem. They are generally found in developing countries, where lack of access to preventive tools and treatment hinders their management. [...]
2020 - 10.1016/j.ijpddr.2020.07.002
International Journal for Parasitology: Drugs and Drug Resistance, Vol. 14 (july 2020) , p. 17-27
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9 p, 193.1 KB |
Genetic characterization of Mycobacterium tuberculosis complex isolates circulating in Abuja, Nigeria
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Molina-Moya, Barbara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Abdurrahman, Saddiq T. (National TB, Buruli Ulcer and Leprosy Control Programme, Abuja, Nigeria) ;
Madukaji, Laura I (Bingham University, Nasarawa State, Nigeria) ;
Gomgnimbou, Michel Kiréopori (Centre Muraz, Bobo-Dioulasso, Burkina Faso) ;
Spinasse, Lizania (Université Paris Sud. Institut for Integrative Biology of the Cell) ;
Gomes Fernandes, Meissiner (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gomes, Harrison Magdinier (Université Paris Sud. Institut for Integrative Biology of the Cell) ;
Kacimi, Sarah (Université Paris Sud. Institut for Integrative Biology of the Cell) ;
Dacombe, Russell (Liverpool School of Tropical Medicine, Liverpool, UK) ;
Bimba, John (Bingham University. Zankli Research Centre and Department of Community Medicine) ;
Lawson, Lovett (Bingham University (Nigèria)) ;
Sola, Christophe (Université Paris Sud. Institut for Integrative Biology of the Cell) ;
Cuevas, Luis E.. (Liverpool School of Tropical Medicine) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Nigeria ranks fourth among the high tuberculosis (TB) burden countries. This study describes the prevalence of drug resistance and the genetic diversity of Mycobacterium tuberculosis in Abuja's Federal Capital Territory. [...]
2018 - 10.2147/IDR.S166986
Infection and drug resistance, Vol. 11 (october 2018) , p. 1617-1625
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