Artículos publicados

Artículos publicados Encontrados 2 registros  La búsqueda tardó 0.03 segundos. 
1.
15 p, 1.7 MB Structural and computational characterization of disease-related mutations involved in protein-protein interfaces / Navío, D. (Barcelona Supercomputing Center) ; Rosell, M. (Barcelona Supercomputing Center) ; Aguirre, Josu (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de la Cruz, Xavier (Institució Catalana de Recerca i Estudis Avançats) ; Fernández-Recio, Juan (Universidad de La Rioja. Instituto de Ciencias de la Vid y del Vino)
One of the known potential effects of disease-causing amino acid substitutions in proteins is to modulate protein-protein interactions (PPIs). To interpret such variants at the molecular level and to obtain useful information for prediction purposes, it is important to determine whether they are located at protein-protein interfaces, which are composed of two main regions, core and rim, with different evolutionary conservation and physicochemical properties. [...]
2019 - 10.3390/ijms20071583
International journal of molecular sciences, Vol. 20 Núm. 7 (january 2019) , p. 1583  
2.
25 p, 3.0 MB Distinct dopamine D2 receptor antagonists differentially impact D2 receptor oligomerization / Wouters, Elise (Laboratory of Toxicology. Department of Bioanalysis. Faculty of Pharmaceutical Sciences. Ghent University) ; Ricarte Marín, Adrián (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Dalton, James A. R.. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Stove, Christophe. (Laboratory of Toxicology. Department of Bioanalysis. Faculty of Pharmaceutical Sciences. Ghent University)
Dopamine D receptors (DR) are known to form transient homodimer complexes, of which the increased formation has already been associated with development of schizophrenia. Pharmacological targeting and modulation of the equilibrium of these receptor homodimers might lead to a better understanding of the critical role played by these complexes in physiological and pathological conditions. [...]
2019 - 10.3390/ijms20071686
International journal of molecular sciences, Vol. 20 Núm. 7 (january 2019) , p. 1686  

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