1.
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44 p, 10.1 MB |
Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes
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Mielczarek, O. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Rogers, C.H. (Immunology Programme. Babraham Institute. Babraham Research Campus) ;
Zhan, Y. (Friedrich Miescher Institute for Biomedical Research) ;
Matheson, L.S. (Immunology Programme. Babraham Institute. Babraham Research Campus) ;
Stubbington, M.J.T. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Schoenfelder, S. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Bolland, D.J. (Immunology Programme. Babraham Institute. Babraham Research Campus) ;
Javierre, B. M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Wingett, S.W. (Bioinformatics Group. Babraham Institute. Babraham Research Campus) ;
Várnai, C. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Segonds-Pichon, A. (Bioinformatics Group. Babraham Institute. Babraham Research Campus) ;
Conn, S.J. (Flinders Health and Medical Research Institute. College of Medicine and Public Health. Flinders University) ;
Krueger, F. (Babraham Institute) ;
Andrews, S. (Babraham Institute) ;
Fraser, P. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Giorgetti, L. (Friedrich Miescher Institute for Biomedical Research) ;
Corcoran, A.E. (Immunology Programme. Babraham Institute. Babraham Research Campus)
To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (V), diversity (D), and joining (J) genes. [...]
2023 - 10.1016/j.celrep.2023.113074
Cell reports, Vol. 42 Núm. 9 (26 2023) , p. 113074
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2.
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11 p, 474.2 KB |
Phase 1/2 Study of the CD56-Targeting Antibody-Drug Conjugate Lorvotuzumab Mertansine (IMGN901) in Combination With Carboplatin/Etoposide in Small-Cell Lung Cancer Patients With Extensive-Stage Disease
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Socinski, Mark A. (Univeristy of Pittsburgh Cancer Institute) ;
Kaye, Frederic J. (University of Florida College of Medicine) ;
Spigel, David R. (Sarah Cannon Research Institute) ;
Kudrik, Fred J. (South Carolina Oncology Associates) ;
Ponce, Santiago (Hospital 12 de Octubre (Madrid)) ;
Ellis, Peter M. (Juravinski Cancer Centre) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Lorigan, Paul (University of Manchester/Christie NHS Foundation Trust) ;
Gandhi, Leena (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Gutierrez, Martin E. (Holy Cross Hospital) ;
Nepert, Dale (Clinical Development. ImmunoGen Inc) ;
Corral, Jesus (Hospital 12 de Octubre (Madrid)) ;
Ares, Luis Paz (Hospital 12 de Octubre (Madrid)) ;
Universitat Autònoma de Barcelona
Lorvotuzumab mertansine (LM, IMGN901) is a CD56-targeting antibody-drug conjugate developed for tumor-selective delivery of the cytotoxic maytansinoid DM1. This phase 1/2 study evaluated the combination of LM with first-line carboplatin/etoposide chemotherapy in patients with extensive-disease small-cell lung cancer. [...]
2017 - 10.1016/j.cllc.2016.09.002
Clinical Lung Cancer, Vol. 18 Núm. 1 (january 2017) , p. 68-76.e2
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3.
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19 p, 8.7 MB |
Complex Evolutionary History With Extensive Ancestral Gene Flow in an African Primate Radiation
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Jensen, Axel (Uppsala University. Department of Ecology and Genetics, Animal Ecology) ;
Swift, Frances (University of Edinburgh. School of Biological Sciences) ;
de Vries, Dorien (University of Salford. School of Science, Engineering and Environment) ;
Beck, Robin (University of Salford. School of Science, Engineering & Environment) ;
Kuderna, Lukas (Illumina Inc) ;
Knauf, Sascha (Federal Research Institute for Animal Health) ;
Chuma, Idrissa S. (Tanzania National Parks) ;
Keyyu, Julius (Tanzania Wildlife Research Institute) ;
Kitchener, Andrew (University of Edinburgh. University of Edinburgh) ;
Farh, Kyle (Illumina Inc) ;
Rogers, Jeffrey (Baylor College of Medicine. Human Genome Sequencing Center) ;
Marques-Bonet, Tomas, 1975- (Institut Català de Paleontologia Miquel Crusafont) ;
Detwiler, Kate (Florida Atlantic University. Department of Biological Sciences) ;
Roos, Christian (Leibniz Institute for Primate Research. German Primate Center) ;
Guschanski, Katerina (Uppsala University. Department of Ecology and Genetics)
Understanding the drivers of speciation is fundamental in evolutionary biology, and recent studies highlight hybridization as an important evolutionary force. Using whole-genome sequencing data from 22 species of guenons (tribe Cercopithecini), one of the world's largest primate radiations, we show that rampant gene flow characterizes their evolutionary history and identify ancient hybridization across deeply divergent lineages that differ in ecology, morphology, and karyotypes. [...]
2023 - 10.1093/molbev/msad247
Molecular Biology and Evolution, Vol. 40, Issue 12 (December 2023) , art. msad247
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5.
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18 p, 1.7 MB |
Addition of Immune Checkpoint Inhibitors to Chemotherapy vs Chemotherapy Alone as First-Line Treatment in Extensive-Stage Small-Cell Lung Carcinoma : A Systematic Review and Meta-Analysis
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Arriola, Edurne (Hospital del Mar (Barcelona, Catalunya)) ;
González-Cao, María (Hospital Dexeus) ;
Domine, Manuel (Hospital Universitario Fundación Jiménez Díaz) ;
de Castro, Javier (Hospital Universitario La Paz (Madrid)) ;
Cobo, Manuel (Instituto de Investigación Biomédica de Málaga) ;
Bernabé, Reyes (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Navarro, Alejandro (Vall d'Hebron Institut d'Oncologia) ;
Sullivan, Ivana (Institut d'Investigació Biomèdica Sant Pau) ;
Trigo, José Manuel (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Mosquera, Joaquín (Complejo Hospitalario Universitario de A Coruña) ;
Crama, Leonardo (Medical Department Roche) ;
Isla, Dolores (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Introduction: The addition of immune checkpoint inhibitors (ICIs) to conventional chemotherapy (CT) as first-line treatment improves survival in extensive-stage small-cell lung cancer (ES-SCLC). The aim of this meta-analysis was to determine the relative efficacy of first-line ICIs compared with CT in patients with ES-SCLC. [...]
2022 - 10.1007/s40487-021-00182-0
Oncology and Therapy, Vol. 10 Núm. 1 (june 2022) , p. 167-184
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6.
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20 p, 3.6 MB |
Improved high-quality genome assembly and annotation of pineapple (Ananas comosus) cultivar md2 revealed extensive haplotype diversity and diversified frs/frf gene family
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Yow, Ashley (North Carolina State University. Department of Horticultural Science) ;
Bostan, Hamed (North Carolina State University. Plants for Human Health Institute) ;
Castanera, Raúl (Centre de Recerca en Agrigenòmica) ;
Ruggieri, Valentino (Biomeets Consulting (Barcelona)) ;
Mengist, Mengist F. (North Carolina State University. Plants for Human Health Institute) ;
Curaba, Julien (North Carolina State University. Plants for Human Health Institute) ;
Young, Roberto (Standard Fruit de Honduras. Research Department of Dole) ;
Gillitt, Nicholas (David H. Murdock Research Institute) ;
Iorizzo, Massimo (North Carolina State University. Plants for Human Health Institute)
Pineapple (Ananas comosus (L. ) Merr. ) is the second most important tropical fruit crop globally, and 'MD2' is the most important cultivated variety. A high-quality genome is important for molecular-based breeding, but available pineapple genomes still have some quality limitations. [...]
2022 - 10.3390/genes13010052
Genes, Vol. 13, Issue 1 (January 2022) , art. 52
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13 p, 1.3 MB |
Functional Analyses Reveal Extensive RRE Plasticity in Primary HIV-1 Sequences Selected under Selective Pressure
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Cunyat, Francesc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Beerens, Nancy (Aarhus University, Aarhus, Denmark) ;
García Rodríguez, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kjems, Jørgen (Aarhus University, Aarhus, Denmark) ;
Cabrera Navarro, Cecilia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
HIV-1 Rev response element (RRE) is a functional region of viral RNA lying immediately downstream to the junction of gp120 and gp41 in the env coding sequence. The RRE is essential for HIV replication and binds with the Rev protein to facilitate the export of viral mRNA from nucleus to cytoplasm. [...]
2014 - 10.1371/journal.pone.0106299
PloS one, Vol. 9 (august 2014)
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18 p, 1.7 MB |
Expansion of the SOS regulon of Vibrio cholerae through extensive transcriptome analysis and experimental validation
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Krin, Evelyne (Institut Pasteur. Département Génomes et Génétique) ;
Pierlé, Sebastian Aguilar (Institut Pasteur. Département Génomes et Génétique) ;
Sismeiro, Odile (Institut Pasteur. Biomics Center for Innovation and Technological Research) ;
Jagla, Bernd (Institut Pasteur. UtechS CB and Hub Bioinformatique et Biostatistique) ;
Dillies, Marie-Agnès (Institut Pasteur. Hub Bioinformatique et Biostatistique) ;
Varet, Hugo (Institut Pasteur. Biomics Center for Innovation and Technological Research) ;
Irazoki, Oihane (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Campoy Sánchez, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Rouy, Zoé (Université Evry-Val-d'Essonne. Institut de Biologie François Jacob) ;
Cruveiller, Stéphane (Université Evry-Val-d'Essonne. Institut de Biologie François Jacob) ;
Médigue, Claudine (Université Evry-Val-d'Essonne. Institut de Biologie François Jacob) ;
Coppée, Jean-Yves (Institut Pasteur. Biomics Center for Innovation and Technological Research) ;
Mazel, Didier (Institut Pasteur. Département Génomes et Génétique)
The SOS response is an almost ubiquitous response of cells to genotoxic stresses. The full complement of genes in the SOS regulon for Vibrio species has only been addressed through bioinformatic analyses predicting LexA binding box consensus and in vitro validation. [...]
2018 - 10.1186/s12864-018-4716-8
BMC genomics, Vol. 19 (May 2018) , art. 373
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10.
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10 p, 1.9 MB |
Extensive dickitization of the Permo-Triassic fluvial sandstones from the eastern Iberian Range, Spain
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Martín-Martín, J. D. (Uppsala University. Department of Earth Sciences) ;
Gómez-Gras, David (Universitat Autònoma de Barcelona. Departament de Geologia) ;
Sanfeliu, T. (Universitat Jaume I. Departament de Ciències Experimentals) ;
Thiry, M. (École des Mines de Paris. Centre de Géociences) ;
Ruiz-Cruz, M. D. (Universidad de Málaga. Departamento de Química Inorgánica, Cristalografía y Mineralogía) ;
Franco, F. (Universidad de Málaga. Departamento de Química Inorgánica, Cristalografía y Mineralogía)
Diagenetic kaolin minerals are very common in the Permo-Triassic succession from the SE Iberian Range, Spain. The morphology and crystal structure of kaolin minerals has been examined in four size fractions (<1 μm, <2 μm, <6. [...]
2007 - 10.1346/CCMN.2007.0550503
Clays and Clay Minerals, Vol. 55, Núm. 5 (2007) , p. 481-490
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