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9 p, 267.6 KB Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial / van der Worp, H. B. (Department of Neurology and Neurosurgery. Brain Center. University Medical Center Utrecht) ; Macleod, Malcolm R. (Centre for Clinical Brain Sciences. University of Edinburgh) ; Bath, P. M. W. (Stroke Trials Unit. Division of Clinical Neuroscience. University of Nottingham) ; Bathula, R. (Stroke Department. Northwick Park Hospital) ; Christensen, Hanne (University of Copenhagen) ; Colam, B. (Centre for Clinical Brain Sciences. University of Edinburgh) ; Cordonnier, C. (University of Lille. Inserm U1171. Degenerative and Vascular Cognitive Disorders. Centre Hospitalier Universitaire Lille) ; Demotes-Mainard, J. (ECRIN) ; Durand-Zaleski, I. (APHP URCEco. University Paris Est Creteil & INSERM. UMR 1123) ; Gluud, C. (Copenhagen Trial Unit. Centre for Clinical Intervention Research. Rigshospitalet. Copenhagen University Hospital) ; Jakobsen, J. C. (Holbæk Hospital (Dinamarca)) ; Kallmünzer, B. (Department of Neurology. University Medical Centre Erlangen) ; Kollmar, R. (Klinik für Neurologie und Neurointensivmedizin. Klinikum Darmstadt) ; Krieger, D. W. (Mediclinic Middle East) ; Lees, K. R. (School of Medicine. Dentistry & Nursing. University of Glasgow) ; Michalski, D. (Department of Neurology. University of Leipzig) ; Molina, Carlos (Hospital Universitari Vall d'Hebron) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Roine, R. O. (Turku University Hospital (Finlàndia)) ; Petersson, J. (Skåne University Hospital (Suècia)) ; Perry, Richard (Stroke Service. National Hospital for Neurology & Neurosurgery) ; Sprigg, N. (Stroke Trials Unit. Division of Clinical Neuroscience. University of Nottingham) ; Staykov, D. (Department of Neurology. Hospital of the Brothers of St. John) ; Szabo, I. (European Stroke Research Network for Hypothermia) ; Vanhooren, G. (AZ Sint-Jan Brugge-Oostende) ; Wardlaw, J. M. (Edinburgh Imaging. Centre for Clinical Brain Sciences. UK Dementia Research Institute. University of Edinburgh) ; Winkel, P. (Copenhagen Trial Unit. Centre for Clinical Intervention Research. Rigshospitalet. Copenhagen University Hospital) ; Schwab, S. (Department of Neurology. University Medical Centre Erlangen) ; Universitat Autònoma de Barcelona
Introduction: We assessed whether modest systemic cooling started within 6 hours of symptom onset improves functional outcome at three months in awake patients with acute ischaemic stroke. Patients and methods: In this European randomised open-label clinical trial with blinded outcome assessment, adult patients with acute ischaemic stroke were randomised to cooling to a target body temperature of 34. [...]
2019 - 10.1177/2396987319844690
European Stroke Journal, Vol. 4 Núm. 3 (january 2019) , p. 254-262  

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