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8 p, 255.3 KB |
Payments for ecosystem services and the fatal attraction of win-win solutions
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Muradian, Roldan (Radboud University Nijmegen) ;
Arsel, Murat (Erasmus University of Rotterdam) ;
Pellegrini, Lorenzo (Erasmus University of Rotterdam) ;
Adaman, Fikret (Bogǎziçi University) ;
Aguilar González, Bernardo (Fundación Neotrópica) ;
Agarwal, Bina (University of Mancheste) ;
Corbera, Esteve (Universitat Autònoma de Barcelona) ;
Ezzine-de-Blas, Driss (Centre de coopération internationale en recherche agronomique pour le développement (CIRAD)) ;
Farley, Joshua (University of Vermont) ;
Froger, Géraldine (Université de Versailles Saint-Quentin-en-Yvelines) ;
Garcia-Frapolli, Eduardo (Universidad Nacional Autónoma de México) ;
Gómez-Baggethun, Erik (Universitat Autònoma de Barcelona) ;
Gowdy, John (Rensselaer Polytechnic Institute) ;
Kosoy, Nicolas (McGill University) ;
Le Coq, Jean-François (Centre de coopération internationale en recherche agronomique pour le développement (CIRAD)) ;
Leroy, Philippe (Radboud University Nijmegen) ;
May, Peter (Universidade Federal Rural do Rio de Janeiro) ;
Méral, Philippe (Institut de Recherche pour le Développement) ;
Mibielli, Paulo (Universidade Estácio de Sá) ;
Norgaard, Richard (University of California) ;
Ozkaynak, Begüm (Bogǎziçi University) ;
Pascual, Unai 1973- (University of Cambridge) ;
Pengue, Walter (Universidad de General Sarmiento) ;
Perez, Mario (Universidad del Valle) ;
Pesche, Denis (Centre de coopération internationale en recherche agronomique pour le développement (CIRAD)) ;
Pirard, Romain (Institut du Développement Durable et des Relations Internationales (IDDRI)) ;
Ramos Martín, Jesús (Universitat Autònoma de Barcelona) ;
Rival, Laura (University of Oxford) ;
Sáenz-Segura, Fernando (Universidade Federal Rural do Rio de Janeiro) ;
Van Hecken, Gert (Universiteit van Antwerpen) ;
Vatn, Arild (Norwegian University of Life Sciences) ;
Vira, Bhaskar (University of Cambridge) ;
Urama, Kevin (African Technology Policy Studies Network)
In this commentary we critically discuss the suitability of payments for ecosystem services and the most important challenges they face. While such instruments can play a role in improving environmental governance, we argue that over-reliance on payments as win-win solutions might lead to ineffective outcomes, similar to earlier experience with integrated conservation and development projects. [...]
2013 -  10.1111/j.1755-263X.2012.00309.x
Conservation letters, Vol. 6 (2013) , p. 274-279
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9 p, 1.7 MB |
KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer
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Sclafani, Francesco (The Royal Marsden NHS Foundation Trust) ;
Chau, Ian (The Royal Marsden NHS Foundation Trust) ;
Cunningham, David (The Royal Marsden NHS Foundation Trust) ;
Hahne, Jens Claus (The Institute of Cancer Research) ;
Vlachogiannis, George (The Institute of Cancer Research) ;
Eltahir, Zakaria (The Royal Marsden NHS Foundation Trust) ;
Lampis, Andrea (The Institute of Cancer Research) ;
Braconi, Chiara (The Institute of Cancer Research) ;
Kalaitzaki, Eleftheria (The Royal Marsden NHS Foundation Trust) ;
De Castro, David Gonzalez (The Royal Marsden NHS Foundation Trust) ;
Wotherspoon, Andrew (The Royal Marsden NHS Foundation Trust) ;
Capdevila Castillón, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Glimelius, Bengt (University of Uppsala) ;
Tarazona, Noelia (Universitat de València) ;
Begum, Ruwaida (The Royal Marsden NHS Foundation Trust) ;
Lote, Hazel (The Institute of Cancer Research) ;
Hulkki Wilson, Sanna (The Royal Marsden NHS Foundation Trust) ;
Mentrasti, Giulia (The Institute of Cancer Research) ;
Brown, Gina (The Royal Marsden NHS Foundation Trust) ;
Tait, Diana (The Royal Marsden NHS Foundation Trust) ;
Oates, Jacqueline (The Royal Marsden NHS Foundation Trust) ;
Valeri, Nicola (The Institute of Cancer Research) ;
Universitat Autònoma de Barcelona
There are limited data on circulating, cell-free, tumour (ct)DNA analysis in locally advanced rectal cancer (LARC). Digital droplet (dd)PCR was used to investigate KRAS/BRAF mutations in ctDNA from baseline blood samples of 97 LARC patients who were treated with CAPOX followed by chemoradiotherapy, surgery and adjuvant CAPOX ± cetuximab in a randomised phase II trial. [...]
2018 - 10.1038/s41598-018-19212-5
Scientific reports, Vol. 8 (january 2018)
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11 p, 2.5 MB |
Patient-Ventilator Synchronization During Non-invasive Ventilation : A Pilot Study of an Automated Analysis System
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Letellier, Christophe (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Luján, Manel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Arnal, Jean-Michel (Hôpital Sainte Musse) ;
Carlucci, Annalisa (University of Insubria) ;
Chatwin, Michelle (Royal Brompton & Harefield (Regne Unit)) ;
Ergan, Begum (Dokuz Eylul University) ;
Kampelmacher, Mike (University Hospital Antwerp) ;
Storre, Jan Hendrik (University Medical Hospital (Alemanya)) ;
Hart, Nicholas (Lane Fox Clinical Respiratory Physiology Research Centre (Regne Unit)) ;
Gonzalez-Bermejo, Jesus (Sorbonne Université) ;
Nava, Stefano (University of Bologna)
Background: Patient-ventilator synchronization during non-invasive ventilation (NIV) can be assessed by visual inspection of flow and pressure waveforms but it remains time consuming and there is a large inter-rater variability, even among expert physicians. [...]
2021 - 10.3389/fmedt.2021.690442
Frontiers in Medical Technology, Vol. 3 (july 2021)
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11 p, 1.8 MB |
Antidepressant use and stroke or mortality risk in the elderly
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Ön, Begüm Irmak (Institute for Medical Information Processing. Biometry and Epidemiology. LMU Munich) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ;
Berger, Úrsula (Institute for Medical Information Processing. Biometry and Epidemiology. LMU Munich) ;
Sabaté, Mònica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ballarín, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Maisterra Santos, Olga (Hospital Universitari Vall d'Hebron) ;
San-Jose, Antonio (Hospital Universitari Vall d'Hebron) ;
Ibáñez, Luisa (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Background and purpose: Current evidence on antidepressant-related stroke or mortality risk is inconsistent. Because the elderly have the highest exposure to antidepressants, the aim was to quantify their association with stroke and mortality risks in this vulnerable population. [...]
2021 - 10.1111/ene.15137
European Journal of Neurology, Vol. 29 (2021) , p. 469-477
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7 p, 825.9 KB |
Basic concepts for tidal volume and leakage estimation in non-invasive ventilation
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Luján, Manel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Lalmolda, Cristina (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ergan, Begüm (Department of Pulmonary and Critical Care. Dokuz Eylül University School of Medicine)
Non-invasive ventilation (NIV) aims to maintain sufficient alveolar ventilation, improve pulmonary gas exchange, assist respiratory muscles, and decrease work of breathing. Monitoring variables such as leaks, tidal volume, and minute ventilation during therapy is crucial to assess the effectiveness of NIV. [...]
2019 - 10.5152/TurkThoracJ.2018.177
Turkish Thoracic Journal, Vol. 20 Núm. 2 (april 2019) , p. 140-146
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8 p, 196.5 KB |
Comparison between MRI and pathology in the assessment of tumour regression grade in rectal cancer
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Sclafani, Francesco (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Brown, Gina (Department of Radiology, The Royal Marsden NHS Foundation Trust) ;
Cunningham, David (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Wotherspoon, Andrew (Department of Histopathology, The Royal Marsden NHS Foundation Trust) ;
Mendes, Larissa Sena Teixeira (Department of Histopathology, The Royal Marsden NHS Foundation Trust) ;
Balyasnikova, Svetlana (Department of Radiology, The Royal Marsden NHS Foundation Trust) ;
Evans, Jessica (Department of Radiology, The Royal Marsden NHS Foundation Trust) ;
Peckitt, Clare (Clinical Research & Development, The Royal Marsden NHS Foundation Trust) ;
Begum, Ruwaida (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Tait, Diana (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Tabernero, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Glimelius, Bengt (Department of Immunology, Genetics and Pathology, Section of Experimental and Clinical Oncology, University of Uppsala) ;
Roselló, Susana (Department of Haematology and Medical Oncology, Biomedical Research Institute INCLIVA, University of Valencia) ;
Thomas, Janet (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Oates, Jacqui (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Chau, Ian (Department of Medicine, The Royal Marsden NHS Foundation Trust)
Limited data exist regarding the correlation between MRI tumour regression grade (mrTRG) and pathological TRG (pTRG) in rectal cancer. mrTRG and pTRG were compared in rectal cancer patients from two phase II trials (EXPERT and EXPERT-C). [...]
2017 - 10.1038/bjc.2017.320
British Journal of Cancer, Vol. 117 (09 2017) , p. 1478-1485
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6 p, 1.4 MB |
Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients
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Sclafani, Francesco (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Chau, Ian (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Cunningham, David (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Lampis, Andrea (The Institute of Cancer Research. Department of Molecular Pathology) ;
Hahne, Jens Claus (The Institute of Cancer Research. Department of Molecular Pathology) ;
Ghidini, Michele (The Institute of Cancer Research. Department of Molecular Pathology) ;
Lote, Hazel (The Institute of Cancer Research. Department of Molecular Pathology) ;
Zito, Domenico (The Institute of Cancer Research. Department of Molecular Pathology) ;
Tabernero, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Glimelius, Bengt (University of Uppsala. Genetics and Pathology, Experimental and Clinical Oncology. Department of Immunology) ;
Cervantes, Andrés (University of Valencia. Biomedical Research Institute INCLIVA. Department of Haematology and Medical Oncology) ;
Begum, Ruwaida (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
De Castro, David Gonzalez (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Wilson, Sanna Hulkki (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Peckitt, Clare (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Eltahir, Zakaria (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Wotherspoon, Andrew (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Tait, Diana (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Brown, Gina (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Oates, Jacqueline (The Royal Marsden NHS Foundation Trust. Department of Medicine) ;
Braconi, Chiara (The Institute of Cancer Research. Department of Cancer Therapeutics) ;
Valeri, Nicola (The Institute of Cancer Research. Department of Molecular Pathology) ;
Universitat Autònoma de Barcelona
Analysis of a polymorphism in mature microRNA-608 (rs4919510) in rectal cancer patients enrolled in a randomized phase II clinical trial identified patient subpopulations who might benefit from the use of an intensified neo-adjuvant treatment strategy with Cetuximab. [...]
2016 - 10.1093/carcin/bgw073
Carcinogenesis, Vol. 37 (july 2016) , p. 852-857
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6 p, 225.1 KB |
Prognostic role of the LCS6 KRAS variant in locally advanced rectal cancer : results of the EXPERT-C trial
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Sclafani, Francesco (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Chau, Ian (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Cunningham, David (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Peckitt, C. (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Lampis, Andrea (The Institute of Cancer Research. Division of Molecular Pathology (UK)) ;
Hahne, Jens Claus (The Institute of Cancer Research. Division of Molecular Pathology (UK)) ;
Braconi, Chiara (The Institute of Cancer Research. Division of Cancer Therapeutics (UK)) ;
Tabernero, Josep (Hospital Universitari Vall d'Hebron) ;
Glimelius, B. (University of Uppsala. Department of Immunology, Genetics and Pathology (Sweden)) ;
Cervantes, Andrés (Universitat de València. Departament d'Hematologia i Oncologia Mèdica) ;
Begum, Ruwaida (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
González De Castro, David (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Hulkki Wilson, Sanna (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Eltahir, Zakaria (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Wotherspoon, Andrew (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Tait, D. (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Brown, Gina (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Oates, J. (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ;
Valeri, Nicola (The Institute of Cancer Research. Division of Molecular Pathology (UK)) ;
Universitat Autònoma de Barcelona
Lethal-7 (let-7) is a tumour suppressor miRNA which acts by down-regulating several oncogenes including KRAS. A single-nucleotide polymorphism (rs61764370, T > G base substitution) in the let-7 complementary site 6 (LCS-6) of KRAS mRNA has been shown to predict prognosis in early-stage colorectal cancer (CRC) and benefit from anti-epidermal growth factor receptor monoclonal antibodies in metastatic CRC. [...]
2015 - 10.1093/annonc/mdv285
Annals of oncology, Vol. 26, Issue 9 (September 2015) , p. 1936-1941
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