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23 p, 4.8 MB

Small neuron-derived extracellular vesicles from individuals with down syndrome propagate tau pathology in the wildtype mouse brain / Ledreux, A. (Knoebel Institute for Healthy Aging. University of Denver) ; Thomas, S. (Knoebel Institute for Healthy Aging. University of Denver) ; Hamlett, E.D. (Department of Pathology and Laboratory Medicine. Medical University of South Carolina) ; Trautman, C. (Knoebel Institute for Healthy Aging. University of Denver) ; Gilmore, A. (Knoebel Institute for Healthy Aging. University of Denver) ; Hager, E.R. (Department of Chemistry and Biochemistry. University of Denver) ; Paredes, D.A. (Knoebel Institute for Healthy Aging. University of Denver) ; Margittai, M. (Department of Chemistry and Biochemistry. University of Denver) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Granholm, A.C. (Knoebel Institute for Healthy Aging. University of Denver)
Individuals with Down syndrome (DS) exhibit Alzheimer's disease (AD) pathology at a young age, including amyloid plaques and neurofibrillary tangles (NFTs). Tau pathology can spread via extracellular vesicles, such as exosomes. [...]
2021 - DOI (Digital Object Identifier)

10.3390/jcm10173931
Journal of clinical medicine, Vol. 10 Núm. 17 (january 2021) , p. 3931

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