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17 p, 3.2 MB The Toxic Effects of Ppz1 Overexpression Involve Nha1-Mediated Deregulation of K+ and H+ Homeostasis / Albacar, Marcel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sacka, Lenka (Institute of Physiology of the Czech Academy of Sciences. Laboratory of Membrane Transport) ; Calafí, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Velázquez, Diego (Institute of Physiology of the Czech Academy of Sciences. Laboratory of Membrane Transport) ; Casamayor Gracia, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Zimmermannova, Olga (Institute of Physiology of the Czech Academy of Sciences. Laboratory of Membrane Transport)
The alteration of the fine-tuned balance of phospho/dephosphorylation reactions in the cell often results in functional disturbance. In the yeast Saccharomyces cerevisiae, the overexpression of Ser/Thr phosphatase Ppz1 drastically blocks cell proliferation, with a profound change in the transcriptomic and phosphoproteomic profiles. [...]
2021 - 10.3390/jof7121010
Journal of Fungi, Vol. 7, Issue 12 (December 2021) , art. 1010  

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