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13 p, 5.2 MB The Verrucomicrobia LexA-Binding Motif : Insights into the Evolutionary Dynamics of the SOS Response / Erill, Ivan (University of Maryland Baltimore County. Erill Lab, Department of Biological Sciences) ; Campoy Sánchez, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Kiliç, Sefa (University of Maryland Baltimore County. Erill Lab, Department of Biological Sciences) ; Barbé García, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The SOS response is the primary bacterial mechanism to address DNA damage, coordinating multiple cellular processes that include DNA repair, cell division, and translesion synthesis. In contrast to other regulatory systems, the composition of the SOS genetic network and the binding motif of its transcriptional repressor, LexA, have been shown to vary greatly across bacterial clades, making it an ideal system to study the co-evolution of transcription factors and their regulons. [...]
2016 - 10.3389/fmolb.2016.00033
Frontiers in Molecular Biosciences, Vol. 3 (july 2016) , art. 33  

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