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Artículos, Encontrados 4 registros
Artículos Encontrados 4 registros  
1.
0 p, 567.1 KB Molecular correlates of response to capmatinib in advanced non-small-cell lung cancer : clinical and biomarker results from a phase I trial / Schuler, M. (German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany) ; Berardi, R. (Università Politecnica delle Marche-Ospedali Riuniti) ; Lim, W.-T (National Cancer Centre Singapore) ; de Jonge, M. (Erasmus MC Cancer Center, Rotterdam) ; Bauer, Todd M (Sarah Cannon Research Institute, and Tennessee Oncology) ; Azaro, Analía (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Gottfried, M. (Oncology Institute of Meir Medical Center) ; Han, J.Y (Center for Lung Cancer, National Cancer Center (Corea del Sud)) ; Lee, D. H. (University of Ulsan College of Medicine (República de Corea)) ; Wollner, M. (Rambam Health Care Campusm (Israel)) ; Hong, David (MD Anderson Cancer Center (Estats Units d'Amèrica)) ; Vogel, A. (Hannover Medical School (Alemanya)) ; Delmonte, A. (Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori) ; Akimov, Mikhail (Novartis Pharma (Siïssa)) ; Ghebremariam, S. (Oncology Global Development-BDM) ; Cui, X. (Novartis Institutes for Biomedical Research) ; Nwana, N. (Oncology Precision Medicine) ; Giovannini, M. (Novartis Pharmaceuticals Corporation(Estats Units d'Amèrica)) ; Kim, T. M. (Seoul National University Hospital)
Dysregulation of receptor tyrosine kinase MET by various mechanisms occurs in 3%-4% of non-small-cell lung cancer (NSCLC) and is associated with unfavorable prognosis. While MET is a validated drug target in lung cancer, the best biomarker strategy for the enrichment of a susceptible patient population still remains to be defined. [...]
2020 - 10.1016/j.annonc.2020.03.293
Annals of oncology, Vol. 31 (march 2020) , p. 789-797  
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2.
12 p, 435.5 KB Phase 1 study of capmatinib in MET-positive solid tumor patients : Dose escalation and expansion of selected cohorts / Bang, Yung-Jue (Seoul National University College of Medicine) ; Su, Wu-Chou (National Cheng Kung University Hospital) ; Schuler, Martin (University Duisburg-Essen and German Cancer Consortium (DKTK)) ; Nam, Do-Hyun (Samsung Medical Center) ; Lim, Wan Teck (National Cancer Centre) ; Bauer, Todd M. (PLLC) ; Azaro, Analía (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Poon, Ronnie Tung Ping (Queen Mary Hospital) ; Hong, David (University of Texas/MD Anderson Cancer Center) ; Lin, Chia-Chi (National Taiwan University Hospital (Taipei, Taiwan)) ; Akimov, Mikhail (Novartis Pharma AG) ; Ghebremariam, Samson (Novartis Pharmaceuticals Corporation) ; Zhao, Sylvia (China Novartis Institutes for Biomedical Research) ; Giovannini, Monica (Novartis Pharmaceuticals Corporation) ; Ma, Brigette (The Chinese University of Hong Kong)
Capmatinib is an oral, ATP-competitive, and highly potent, type 1b MET inhibitor. Herein, we report phase 1 dose-escalation results for capmatinib in advanced MET-positive solid tumor patients and dose expansion in advanced non-lung tumors. [...]
2019 - 10.1111/cas.14254
Cancer Science, Vol. 111 (december 2019) , p. 536-547  
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3.
10 p, 426.6 KB A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies / Spreafico, A. (University of Toronto. Princess Margaret Cancer Centre. Division of Medical Oncology and Hematology (Canada)) ; Delord, Jean-Pierre (Institut Claudius Regaud (France)) ; Mattos Arruda, Leticia de (Hospital Universitari Vall d'Hebron) ; Berge, Y. (Institut Claudius Regaud (France)) ; Pérez Rodon, Jordi (Hospital Universitari Vall d'Hebron) ; Cottura, E. (Institut Claudius Regaud (France)) ; Bedard, Philippe L (University of Toronto. Princess Margaret Cancer Centre. Division of Medical Oncology and Hematology (Canada)) ; Akimov, Mikhail (Novartis Pharma AG (Switzerland)) ; Lu, H. (Novartis Pharmaceuticals Corp (USA)) ; Pain, S. (Novartis Pharmaceuticals Corp (USA)) ; Kaag, A. (Novartis Pharma AG (Switzerland)) ; Siu, L. L. (University of Toronto. Princess Margaret Cancer Centre. Division of Medical Oncology and Hematology (Canada)) ; Cortés, Javier (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Heat-shock protein 990 (HSP990) is a potent and selective synthetic small-molecule HSP90 inhibitor. The primary objectives of this phase I first-in-human study were to determine dose-limiting toxicities (DLTs), maximum-tolerated dose (MTD) and recommended phase II dose (RP2D). [...]
2015 - 10.1038/bjc.2014.653
British Journal of Cancer, Vol. 112 (February 2015) , p. 650-659  
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4.
6 p, 263.8 KB A multicentre phase II gene expression profiling study of putative relationships between tumour biomarkers and clinical response with erlotinib in non-small-cell lung cancer / Tan, E. H. (National Cancer Centre (Singapur). Department of Medical Oncology) ; Ramlau, Rodryg (Regional Lung Disease Centre (Poznan). Department of Oncology) ; Pluzanska, A. (Regional Oncology Centre (Lodz, Polònia). Oncological Chemotherapy Clinic) ; Kuo, H. -P. (Chang Gung Memorial Hospital (Linkou, Taiwan). Department of Thoracic Medicine) ; Reck, Martin (Hospital Grosshansdorf (Grosshansdorf, Alemanya). Department of Thoracic Oncology) ; Milanowski, J. (Akademia Medyczna w Lublinie (Lublin, Polònia). Department of Pneumology, Oncology and Allergology) ; Au, J. S. -K. (Queen Elizabeth Hospital (Hong Kong). Department of Clinical Oncology) ; Felip, Enriqueta (Hospital Universitari Vall d'Hebron) ; Yang, P. -C. (National Taiwan University Hospital (Taipei, Taiwan)) ; Damyanov, D. (Specialized Hospital for Active Treatment in Oncology (Sofia, Bulgaria)) ; Orlov, S. (Pavlov State Medical University. Research Institute of Pulmonology (Sant Petersburg, Rússia)) ; Akimov, Mikhail (Hoffmann-La Roche (Basel, Suïssa)) ; Delmar, P. (Hoffmann-La Roche (Basel, Suïssa)) ; Essioux, L. (Hoffmann-La Roche (Basel, Suïssa)) ; Hillenbach, C. (Hoffmann-La Roche (Basel, Suïssa)) ; Klughammer, B. (Hoffmann-La Roche (Basel, Suïssa)) ; McLoughlin, P. (Hoffmann-La Roche (Basel, Suïssa)) ; Baselga Torres, Josep, 1959-2021, (Hospital Universitari Vall d'Hebron)
Background: Identification of appropriate markers for predicting clinical benefit with erlotinib in non-small-cell lung cancer (NSCLC) may be able to guide patient selection for treatment. This open-label, multicentre, phase II trial aimed to identify genes with potential use as biomarkers for clinical benefit from erlotinib therapy. [...]
2010
Annals of oncology, Vol. 21, Issue 2 (2010) , p. 217-222  
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