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Characterization of the denaturation of bovine serum albumin (BSA) protein by means of a differential-mode microwave microfluidic sensor based on slot resonators
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Muñoz Enano, Jonathan (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica) ;
Peytral-Rieu, Olivia (Centre national de la recherche scientifique. Laboratoire d'analyse et d'architecture des systèmes) ;
Vélez Rasero, Paris (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica) ;
Dubuc, David (Centre national de la recherche scientifique. Laboratoire d'analyse et d'architecture des systèmes) ;
Grenier, Katia (Centre national de la recherche scientifique. Laboratoire d'analyse et d'architecture des systèmes) ;
Martín, Ferran (Martín Antolín) (Universitat Autònoma de Barcelona. Departament d'Enginyeria Electrònica)
This paper presents a differential-mode microwave microfluidic sensor useful for the characterization/detection of the denaturation of Bovine Serum Albumin (BSA), a protein with numerous biochemical applications, caused by a chaotropic agent, specifically, urea. [...]
2022 -  10.1109/JSEN.2022.3181542
IEEE sensors journal, Vol. 22, issue 14 (Juliol 2022) , p. 14075-14083
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2.
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43 p, 2.5 MB |
Validation and Applications of Protein-Ligand Docking Approaches Improved for Metalloligands with Multiple Vacant Sites
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Sciortino, Giuseppe (Universitat Autònoma de Barcelona. Departament de Química) ;
Garribba, Eugenio (Università di Sassari. Dipartimento di Chimica e Farmacia) ;
Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química)
Decoding the interaction between coordination compounds and proteins is of fundamental importance in biology, pharmacy, and medicine. In this context, protein-ligand docking represents a particularly interesting asset to predict how small compounds could interact with biomolecules, but to date, very little information is available to adapt these methodologies to metal-containing ligands. [...]
2019 - 10.1021/acs.inorgchem.8b02374
Inorganic chemistry, Vol. 58, Issue 1 (January 2019) , p. 294-306
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3.
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15 p, 1.2 MB |
Unveiling VIVO2+ Binding Modes to Human Serum Albumins by an Integrated Spectroscopic-Computational Approach
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Sciortino, Giuseppe (Universitat Autònoma de Barcelona. Departament de Química) ;
Sanna, Daniele (Consiglio Nazionale delle Ricerche. Istituto di Chimica Biomolecolare) ;
Lubinu, Giuseppe (Università di Sassari. Dipartimento di Chimica e Farmacia) ;
Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química) ;
Garribba, Eugenio (Università di Sassari. Dipartimento di Chimica e Farmacia)
Human serum albumin (HSA) is involved in the transport of metal ions and potential metallodrugs. Depending on the metal, several sites are available, among which are N-terminal (NTS) and multi-metal binding sites (MBS). [...]
2020 - 10.1002/chem.202001492
Chemistry, Vol. 26, Issue 49 (September 2020) , p. 11316-11326
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4.
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12 p, 1.2 MB |
Neuroimaging analyses from a randomized, controlled study to evaluate plasma exchange with albumin replacement in mild-to-moderate Alzheimer's disease : additional results from the AMBAR study
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Cuberas-Borrós, Gemma (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roca, Isabel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castell-Conesa, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Núñez, Laura (Alzheimer's Research Group (Barcelona)) ;
Boada, Mercè (Instituto de Salud Carlos III) ;
López, Oscar L. (University of Pittsburgh School of Medicine) ;
Grifols, Carlota (Alzheimer's Research Group (Barcelona)) ;
Barceló Torns, Miquel (Alzheimer's Research Group (Barcelona)) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Páez, Antonio (Alzheimer's Research Group (Barcelona)) ;
Universitat Autònoma de Barcelona
This study was designed to detect structural and functional brain changes in Alzheimer's disease (AD) patients treated with therapeutic plasma exchange (PE) with albumin replacement, as part of the recent AMBAR phase 2b/3 clinical trial. [...]
2022 - 10.1007/s00259-022-05915-5
European Journal of Nuclear Medicine and Molecular Imaging, Vol. 49 (july 2022) , p. 4589-4600
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5.
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12 p, 1.1 MB |
Effects of albumin on survival after a hepatic encephalopathy episode : Randomized double-blind trial and meta-analysis
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Ventura-Cots, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Simón-Talero, Macarena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Poca Sans, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Ariza, Xavier (Hospital Clínic i Provincial de Barcelona) ;
Masnou, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sánchez-Delgado, Jordi (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Llop, Elba (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Cañete Hidalgo, Nuria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Martín-Llahí, Marta (Hospital de Sant Joan Despí Moisès Broggi) ;
Amador, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Martínez, Javier (Hospital Universitario Ramón y Cajal (Madrid)) ;
Clemente-Sanchez, Ana (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Puente, Angela (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria)) ;
Torrens, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alvarado-Tapias, Edilmar (Institut d'Investigació Biomèdica Sant Pau) ;
Napoleone, Laura (Hospital Clínic i Provincial de Barcelona) ;
Miquel Planas, Mireia (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ardèvol Ribalta, Alba (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Casas Rodrigo, Meritxell (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Calleja, Jose Luis (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Solé, Cristina (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Soriano, German (Institut d'Investigació Biomèdica Sant Pau) ;
Genescà Ferrer, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
No therapies have been proven to increase survival after a hepatic encephalopathy (HE) episode. We hypothesize that two doses of albumin could improve 90-day survival rates after a HE episode. Methods: (1) A randomized double-blind, placebo-controlled trial (BETA) was conducted in 12 hospitals. [...]
2021 - 10.3390/jcm10214885
Journal of clinical medicine, Vol. 10 Núm. 21 (11 2021) , p. 4885
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6.
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24 p, 3.2 MB |
Exogenous albumin is crucial for pig sperm to elicit in vitro capacitation whereas bicarbonate only modulates its efficiency
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Resende Chaves, Bruna (Universitat de Girona. Institut de Tecnologia Agroalimentària) ;
Pavaneli, Ana Paula (University of São Paulo. Department of Animal Reproduction) ;
Blanco Prieto, Olga (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Pinart, Elisabeth (Universitat de Girona. Departament de Biologia) ;
Bonet, Sergi (Universitat de Girona. Departament de Biologia) ;
Zangeronimo, Marcio Gilberto (Federal University of Lavras, Brazil. Department of Veterinary Medicine) ;
Rodríguez Gil, Joan Enric (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Yeste Oliveras, Marc (Universitat de Girona. Departament de Biologia)
This work sought to address whether the presence of exogenous bicarbonate is required for pig sperm to elicit in vitro capacitation and further progesterone-induced acrosome exocytosis. For this purpose, sperm were either incubated in a standard in vitro capacitation medium or a similar medium with different concentrations of bicarbonate (either 0 mM, 5 mM, 15 mM or 38 mM) and BSA (either 0 mg/mL or 5 mg/mL). [...]
2021 - 10.3390/biology10111105
Biology, Vol. 10 Núm. 11 (november 2021) , p. 1105
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9 p, 632.8 KB |
Human Albumin Impairs Amyloid β-peptide Fibrillation Through its C-terminus : From docking Modeling to Protection Against Neurotoxicity in Alzheimer's disease
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Picón-Pagès, Pol (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ;
Bonet, Jaume (Universitat Pompeu Fabra. Grup de Recerca en Bioinformàtica Estructural) ;
García-García, Javier (Universitat Pompeu Fabra. Grup de Recerca en Bioinformàtica Estructural) ;
Garcia-Buendia, Joan (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ;
Gutiérrez, Daniela (Pontificia Universidad Católica de Chile. Departamento de Biología Celular y Molecular) ;
Valle García, Javier (Universitat Pompeu Fabra. Grup de Recerca en Proteòmica i Química de Proteïnes) ;
Gómez-Casuso, Carmen E. S. (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ;
Sidelkivska, Valeriya (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ;
Alvarez, Alejandra (Pontificia Universidad Católica de Chile. Departamento de Biología Celular y Molecular) ;
Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Suades, Albert (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Fernàndez-Busquets, Xavier (Barcelona Institute for Global Health (ISGlobal)) ;
Andreu Martínez, David (Universitat Pompeu Fabra. Grup de Recerca en Proteòmica i Química de Proteïnes) ;
Vicente, Rubén (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ;
Oliva Miguel, Baldomero (Universitat Pompeu Fabra. Grup de Recerca en Bioinformàtica Estructural) ;
Muñoz, Francisco J. (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular)
Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate into β-sheets that are neurotoxic. [...]
2019 - 10.1016/j.csbj.2019.06.017
Computational and Structural Biotechnology Journal, Vol. 17 (2019) , p. 963-971
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10.
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19 p, 2.4 MB |
DFT Protocol for EPR prediction of paramagnetic Cu(II) complexes and application to protein binding sites
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Sciortino, Giuseppe (Universitat Autònoma de Barcelona. Departament de Química) ;
Lubinu, Giuseppe (Dipartimento di Chimica e Farmacia, Università di Sassar) ;
Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química) ;
Garribba, Eugenio (Dipartimento di Chimica e Farmacia, Università di Sassar)
With the aim to provide a general protocol to interpret electron paramagnetic resonance (EPR) spectra of paramagnetic copper(II) coordination compounds, density functional theory (DFT) calculations of spin Hamiltonian parameters g and A for fourteen Cu(II) complexes with different charges, donor sets, and geometry were carried out using ORCA software. [...]
2018 - 10.3390/magnetochemistry4040055
Magnetochemistry, Vol. 4 (2018) , p. 1-19
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