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1.
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11 p, 2.7 MB |
Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control
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Masip, Jenifer (Hospital Universitari Joan XXIII de Tarragona) ;
Rallón, Norma (Hospital Universitario Rey Juan Carlos (Madrid)) ;
Yeregui, Elena (Hospital Universitari Joan XXIII de Tarragona) ;
Olona, Montserrat (Hospital Universitari Joan XXIII de Tarragona) ;
Resino, Salvador (Instituto de Salud Carlos III) ;
Benito, José M. (Hospital Universitario Rey Juan Carlos (Madrid)) ;
Viladés, Consuelo (Instituto de Salud Carlos III) ;
García-Pardo, Graciano (Hospital Universitari Joan XXIII de Tarragona) ;
Alcami, Jose (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ruiz-Mateos, Ezequiel (Universidad de Sevilla) ;
Gómez-Bertomeu, Frederic (Hospital Universitari Joan XXIII de Tarragona) ;
Vargas, Montserrat (Hospital Universitari Joan XXIII de Tarragona) ;
Navarro, Marta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Oteo, José A. (Hospital Universitario San Pedro) ;
Pineda, Juan A. (Unidad de Investigación Hospital Universitario de Valme) ;
Martí, Anna (Hospital Universitari Joan XXIII de Tarragona) ;
Alba, Verónica (Hospital Universitari Joan XXIII de Tarragona) ;
Vidal, Francesc (Instituto de Salud Carlos III) ;
Peraire, Joaquin (Instituto de Salud Carlos III) ;
Rull, Anna (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunological HIV control in the long term that have been designated as models of an HIV functional cure. [...]
2022 -  10.3389/fimmu.2022.822272
Frontiers in immunology, Vol. 13 (april 2022)
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2.
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14 p, 1.7 MB |
Immunogenic dynamics and SARS-CoV-2 variant neutralisation of the heterologous ChAdOx1-S/BNT162b2 vaccination : Secondary analysis of the randomised CombiVacS study
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García-Pérez, Javier (Instituto de Salud Carlos III) ;
González-Pérez, María (Instituto de Salud Carlos III) ;
Castillo de la Osa, María (Instituto de Salud Carlos III) ;
Borobia, Alberto M. (Universidad Autónoma de Madrid) ;
Castaño, Luis (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Bertrán, María Jesús (Hospital Clínic i Provincial de Barcelona) ;
Campins Martí, Magda (Hospital Universitari Vall d'Hebron) ;
Portolés, Antonio (Universidad Complutense de Madrid) ;
Lora, David (Universidad Complutense de Madrid) ;
Bermejo, Mercedes (Instituto de Salud Carlos III) ;
Conde, Patricia (Instituto de Salud Carlos III) ;
Hernández-Gutierrez, Lourdes (Instituto de Salud Carlos III) ;
Carcas, Antonio (Hospital Universitario La Paz (Madrid)) ;
Arana-Arri, Eunate (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Tortajada, Marta (Hospital Clínic i Provincial de Barcelona) ;
Fuentes Camps, Inmaculada (Hospital Universitari Vall d'Hebron) ;
Ascaso, Ana (Hospital Clínico San Carlos (Madrid)) ;
García-Morales, María Teresa (Universidad Complutense de Madrid) ;
Erick de la Torre-Tarazona, Humberto (Instituto de Salud Carlos III) ;
Arribas, Jose (Hospital Universitario La Paz (Madrid)) ;
Imaz-Ayo, Natale (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Mellado-Pau, Eugènia (Hospital Clínic i Provincial de Barcelona) ;
Agustí Escasany, M. Antònia (Hospital Universitari Vall d'Hebron) ;
Pérez-Ingidua, Carla (Hospital Clínico San Carlos (Madrid)) ;
Gómez de la Cámara, Agustín (Universidad Complutense de Madrid) ;
Ochando, Jordi (Instituto de Salud Carlos III) ;
Belda-Iniesta, Cristobal (Instituto de Salud Carlos III) ;
Frías, Jesús (Hospital Universitario La Paz (Madrid)) ;
Alcami, Jose (Instituto de Salud Carlos III) ;
Pérez-Olmeda, Mayte (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
The CombiVacS study was designed to assess immunogenicity and reactogenicity of the heterologous ChAdOx1-S/BNT162b2 combination, and 14-day results showed a strong immune response. The present secondary analysis addresses the evolution of humoral and cellular response up to day 180. [...]
2022 - 10.1016/j.eclinm.2022.101529
EClinicalMedicine, Vol. 50 (july 2022)
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3.
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24 p, 2.3 MB |
An Efficient Microarray-Based Genotyping Platform for the Identification of Drug-Resistance Mutations in Majority and Minority Subpopulations of HIV-1 Quasispecies
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Martín, Verónica (Centro de Biología Molecular Severo Ochoa) ;
Perales Viejo, Celia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández-Algar, María (Centro de Astrobiología (Madrid)) ;
Dos Santos, Helena G. (Centro de Biología Molecular Severo Ochoa) ;
Garrido, Patricia (Biotherapix (Madrid)) ;
Pernas, María (Biotherapix (Madrid)) ;
Parro, Víctor (Centro de Astrobiología (Madrid)) ;
Moreno, Miguel (Centro de Astrobiología (Madrid)) ;
García-Pérez, Javier (Instituto de Salud Carlos III) ;
Alcami, Jose (Instituto de Salud Carlos III) ;
Torán, José Luis (Biotherapix (Madrid)) ;
Abia, David (Centro de Biología Molecular Severo Ochoa) ;
Domingo, Esteban (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Briones Llorente, Carlos (Centro de Astrobiología (Madrid)) ;
Universitat Autònoma de Barcelona
The response of human immunodeficiency virus type 1 (HIV-1) quasispecies to antiretroviral therapy is influenced by the ensemble of mutants that composes the evolving population. Low-abundance subpopulations within HIV-1 quasispecies may determine the viral response to the administered drug combinations. [...]
2016 - 10.1371/journal.pone.0166902
PloS one, Vol. 11 (december 2016)
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4.
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18 p, 4.2 MB |
Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors
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González, Nuria (Instituto de Salud Carlos III) ;
McKee, Krisha (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Washington, United States of America) ;
Lynch, Rebecca M. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Washington, United States of America) ;
Georgiev, Ivelin S. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Washington, United States of America) ;
Jimenez, Laura (Instituto de Salud Carlos III) ;
Grau, Eulàlia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Yuste, Eloísa (Hospital Clínic i Provincial de Barcelona) ;
Kwong, Peter D. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Washington, United States of America) ;
Mascola, John R. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Washington, United States of America) ;
Alcami, Jose (Instituto de Salud Carlos III)
Only a small fraction of HIV-1-infected patients develop broadly neutralizing antibodies (bNAbs), a process generally associated to chronic antigen stimulation. It has been described that rare aviremic HIV-1-infected patients can generate bNAbs but this issue remains controversial. [...]
2018 - 10.1371/journal.pone.0193773
PloS one, Vol. 13 (march 2018)
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5.
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27 p, 2.5 MB |
Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells
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Grau Expósito, Judith (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Perea, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Suppi, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Massana, Núria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vergara, Ander (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Soler, María José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Trinité, Benjamin (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Universitat de Vic) ;
García-Pérez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Alcami, Jose (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Serrano-Mollar, Anna (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Rosado Rodríguez, Joel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Genescà Ferrer, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
The development of physiological models that reproduce SARS-CoV-2 infection in primary human cells will be instrumental to identify host-pathogen interactions and potential therapeutics. Here, using cell suspensions directly from primary human lung tissues (HLT), we have developed a rapid platform for the identification of viral targets and the expression of viral entry factors, as well as for the screening of viral entry inhibitors and anti-inflammatory compounds. [...]
2022 - 10.1371/journal.ppat.1010171
PLOS pathogens, Vol. 18 (january 2022)
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6.
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10 p, 198.4 KB |
HIV Research for Prevention 2018 : From Research to Impact Conference Summary and Highlights
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Shacklett, Barbara L. (University of California. Medical Microbiology and Immunology) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hightow-Weidman, Lisa (University of North Carolina) ;
Mgodi, Nyaradzo (University of Zimbabwe College of Health Sciences) ;
Alcami, Jose (Instituto de Salud Carlos III) ;
Buchbinder, Susan (San Francisco Department of Public Health) ;
Chirenje, Mike (University of Zimbabwe College of Health Sciences) ;
Dabee, Smritee (University of Cape Town) ;
Diallo, Mamadou (University Laval) ;
Dumchev, Kostyantyn (Ukrainian Institute on Public Health Policy) ;
Herrera, Carolina (Imperial College London) ;
Levy, Matthew E. (The George Washington University. Department of Epidemiology and Biostatistics) ;
Martin Gayo, Enrique (Instituto de Investigación Hospital Universitario de la Princesa) ;
Makoah, Nigel Aminake (Centre for HIV and STIs, National Institute for Communicable Diseases) ;
Mitchell, Kate M. (Imperial College London) ;
Mugwanya, Kenneth (University of Washington) ;
Reddy, Krishnaveni (University of the Witwatersrand) ;
Rodríguez, Maria Luisa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodriguez-Garcia, Marta (Geisel School of Medicine at Dartmouth) ;
Shover, Chelsea L. (Stanford University) ;
Shrivastava, Tripti (Translational Health Science and Technology Institute (Índia)) ;
Tomaras, Georgia (Duke University. Departments of Surgery, Immunology, and Molecular Genetics and Microbiology) ;
Van Diepen, Michiel (University of Cape Town) ;
Walia, Monika (Population Council) ;
Warren, Mitchell (AVAC) ;
Manrique, Amapola (Global HIV Vaccine Enterprise) ;
Thyagarajan, Bargavi (Global HIV Vaccine Enterprise) ;
Torri, Tamara (International AIDS Society)
The HIV Research for Prevention (HIVR4P) conference is dedicated to advancing HIV prevention research, responding to a growing consensus that effective and durable prevention will require a combination of approaches as well as unprecedented collaboration among scientists, practitioners, and community workers from different fields and geographic areas. [...]
2019 - 10.1089/aid.2019.0074
AIDS Research and Human Retroviruses, Vol. 35 Num. 7 (2019) , p. 598-607
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7.
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15 p, 676.0 KB |
Mechanisms of abrupt loss of virus control in a cohort of previous HIV controllers
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Rosás Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bellido, Rocío (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fernández, Marco A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cobarsi, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Crespo Casal, Manuel (Complexo Hospitalario Universitario de Vigo) ;
Dorrell, Lucy (Nuffield Department of Medicine, University of Oxford) ;
Del Romero, Jorge (Centro Sanitario Sandoval, Madrid) ;
Alcami, Jose (Instituto de Salud Carlos III) ;
Paredes, Roger (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
A few individuals can control HIV infection without the need for antiretroviral treatment and are referred to as HIV controllers. We have studied HIV controllers who suddenly lose this ability and present with high in vivo viral replication and decays in their CD4 + T-cell counts to identify potential immune and virological factors that were responsible for initial virus control. [...]
2019 - 10.1128/JVI.01436-18
Journal of Virology, Vol. 93 (february 2019)
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