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7 p, 196.7 KB |
Relationship between the Use of Inhaled Steroids for Chronic Respiratory Diseases and Early Outcomes in Community-Acquired Pneumonia
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Almirall i Pujol, Jordi (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Bolibar i Ribas, Ignasi (Institut d'Investigació Biomèdica Sant Pau) ;
Serra-Prat, Mateu (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Palomera, Elisabet (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Roig, Jordi (Hospital Nostra Senyora de Meritxell (Principat d'Andorra)) ;
Hospital, Imma (Institut Català de la Salut. Atenció Primària Barcelona Ciutat) ;
Carandell, Eugenia (IB-SALUT Balears, Palma de Mallorca) ;
Agustí, Mercè (Institut Català de la Salut. Atenció Primària Barcelona Ciutat) ;
Ayuso, Pilar (INSALUD, Valencia) ;
Estela, Andreu (IB-SALUT Balears, Palma de Mallorca) ;
Torres, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Universitat Autònoma de Barcelona
The role of inhaled steroids in patients with chronic respiratory diseases is a matter of debate due to the potential effect on the development and prognosis of community-acquired pneumonia (CAP). We assessed whether treatment with inhaled steroids in patients with chronic bronchitis, COPD or asthma and CAP may affect early outcome of the acute pneumonic episode. [...]
2013 -  10.1371/journal.pone.0073271
PloS one, Vol. 8 (september 2013)
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10 p, 1.2 MB |
Impact of Lymphocyte and Neutrophil Counts on Mortality Risk in Severe Community-Acquired Pneumonia with or without Septic Shock
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Güell, Estel (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Martín-Fernandez, Marta (Hospital Clínico Universitario de Valladolid) ;
de la Torre, Maria del Carmen (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Palomera, Elisabet (Consorci Sanitari del Maresme) ;
Serra, Mateu (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Martinez, Rafael (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Solsona, Manel (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Miró, Gloria (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Vallès, Jordi (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Fernández, Samuel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Cortés, Edgar (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ferrer, Vanessa (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Morales, Marc (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Yébenes, Juan C. (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Almirall i Pujol, Jordi (Consorci Sanitari del Maresme) ;
Bermejo-Martin, Jesús F.. (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Universitat Autònoma de Barcelona
Background: Community-acquired pneumonia (CAP) is a frequent cause of death worldwide. As recently described, CAP shows different biological endotypes. Improving characterization of these endotypes is needed to optimize individualized treatment of this disease. [...]
2019 - 10.3390/jcm8050754
Journal of clinical medicine, Vol. 8 (may 2019)
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3.
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7 p, 497.0 KB |
Lower Respiratory Tract Infection and Short-Term Outcome in Patients With Acute Respiratory Distress Syndrome
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Zampieri, Fernando G. (Hospital do Coração, São Paulo, Brazil) ;
Póvoa, Pedro (Nova Medical School, CEDOC, New University of Lisbon, Lisbon, Portugal) ;
Salluh, Jorge I. (Programa de Pós-graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio Janeiro, Brazil) ;
Rodríguez, Alejandro (Hospital Universitari Joan XXIII de Tarragona) ;
Valade, Sandrine (Intensive Care Unit, Saint-Louis University Hospital, AP-HP and Paris-Diderot University, Sorbonne Paris Cité, Paris, France) ;
Andrade Gomes, José (Hospital da Luz (Lisboa, Portugal)) ;
Reignier, Jean (Medical ICU, CHU de Nantes, Nantes, France) ;
Molinos, Elena (Serviço de Medicina Intensiva, Hospital Pedro Hispano, ULS de Matosinhos, Matosinhos, Portugal) ;
Almirall i Pujol, Jordi (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Boussekey, Nicolas (Service de Réanimation Médicale et Maladies Infectieuses, Hôpital Chatiliez, Tourcoing, France) ;
Socias, Lorenzo (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Ramirez, Paula (Hospital Universitari i Politècnic La Fe (València)) ;
Viana, William N. (Hospital Copa D'Or, Copacabana, Rio de Janeiro, Brazil) ;
Rouzé, Anahita (University Hospital of Lille (França)) ;
Nseir, Saad (University Hospital of Lille (França)) ;
Martin-Loeches, Ignacio (Welcome Trust-HRB Clinical Research Facility, St James Hospital, Dublin, Ireland)
To assess whether ventilator-associated lower respiratory tract infections (VA-LRTIs) are associated with mortality in critically ill patients with acute respiratory distress syndrome (ARDS). Post hoc analysis of prospective cohort study including mechanically ventilated patients from a multicenter prospective observational study (TAVeM study); VA-LRTI was defined as either ventilator-associated tracheobronchitis (VAT) or ventilator-associated pneumonia (VAP) based on clinical criteria and microbiological confirmation. [...]
2018 - 10.1177/0885066618772498
Journal of Intensive Care Medicine, Vol. 35 (april 2018) , p. 588-594
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11 p, 838.8 KB |
Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia : a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)
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Welte, Tobias (Carl-Neuberg-Str. 1, 30625 Hannover, Germany) ;
Dellinger, R. Phillip (Cooper Medical School of Rowan University. Department of Medicine) ;
Ebelt, Henning (Universitätsklinikum Halle (Saale). Klinik und Poliklinik für Innere Medizin III) ;
Ferrer, Miguel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Opal, Steven M. (Rhode Island Hospital. Infectious Disease Division) ;
Singer, Mervyn (University College London. Bloomsbury Institute of Intensive Care Medicine) ;
Vincent, Jean-Louis (Erasme University Hospital. Department of Intensive Care) ;
Werdan, Karl (St. James's Hospital. Trinity Centre for Health Sciences) ;
Martin-Loeches, Ignacio (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Almirall i Pujol, Jordi (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ignacio Ayestarán, Jose (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Nuding, Sebastian (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sirgo Rodríguez, Gonzalo (Hospital Universitari Joan XXIII de Tarragona) ;
Shankar-Hari, Manu (Guy's and St. Thomas' NHS Foundation Trust. Intensive Care Medicine) ;
Álvarez Lerma, Francisco (Hospital del Mar (Barcelona, Catalunya)) ;
Riessen, Reimer (Universitätsklinikum Tübingen. Internistische Intensivstation) ;
Sirvent, Josep-Maria (Hospital Universitari de Girona Doctor Josep Trueta) ;
Kluge, Stefan (Universitätsklinikum Hamburg-Eppendorf. Klinik für Intensivmedizin) ;
Zacharowski, Kai (Universitätsklinikum Frankfurt. Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie) ;
Bonastre Mora, Juan (Hospital Universitari i Politècnic La Fe (València)) ;
Lapp, Harald (Medizinische Klinik, Kardiologie und Intensivmedizin, Helios Klinikum Erfurt, Erfurt, Germany) ;
Wöbker, Gabriele (Klinik für Intensivmedizin, Helios Universitätsklinikum Wuppertal, Wuppertal, Germany) ;
Achtzehn, Ute (Klinikum Chemnitz gGmbH. Innere Medizin IV - Pneumologie) ;
Brealey, David (Critical Care Unit, NIHR University College London Hospitals Biomedical Research Centre, University College London Hospitals, NHS Foundation Trust, London, UK) ;
Kempa, Axel (Katharinenhospital, Stuttgart. Klinik für Allgemeine Innere Medizin) ;
Sánchez García, Miguel (Hospital Clínico San Carlos (Madrid)) ;
Brederlau, Jörg (Helios Klinikum Berlin-Buch, Klinik für Intensivmedizin) ;
Kochanek, Matthias (University Hospital of Cologne. Department I of Internal Medicine) ;
Reschreiter, Henrik Peer (Poole Hospital NHS Foundation Trust) ;
Wise, Matthew P. (Heath Park, Cardiff) ;
Belohradsky, Bernd H. (University Children's Hospital Munich) ;
Bobenhausen, Iris (Biotest AG) ;
Dälken, Benjamin (Biotest AG) ;
Dubovy, Patrick (Biotest AG) ;
Langohr, Patrick (Biotest AG) ;
Mayer, Monika (Biotest AG) ;
Schüttrumpf, Jörg (Biotest AG) ;
Wartenberg-Demand, Andrea (Biotest AG) ;
Wippermann, Ulrike (Biotest AG) ;
Wolf, Daniele (Biotest AG) ;
Torres, Antoni (Hospital Clínic i Provincial de Barcelona)
The CIGMA study investigated a novel human polyclonal antibody preparation (trimodulin) containing ~ 23% immunoglobulin (Ig) M, ~ 21% IgA, and ~ 56% IgG as add-on therapy for patients with severe community-acquired pneumonia (sCAP). [...]
2018 - 10.1007/s00134-018-5143-7
Intensive Care Medicine, Vol. 44 (april 2018) , p. 438-448
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7 p, 824.3 KB |
Serum levels of immunoglobulins and severity of community-acquired pneumonia
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de la Torre, Maria del Carmen (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Torán, Pere (Unitat Suport Recerca Metropolitana Nord ICS, Santa Coloma de Gramanet) ;
Serra-Prat, Mateu (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Palomera, Elisabet (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Güell, Estel (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Vendrell, Ester (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Yébenes, Juan Carlos (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Torres, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Almirall i Pujol, Jordi (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Universitat Autònoma de Barcelona
There is evidence of a relationship between severity of infection and inflammatory response of the immune system. The objective is to assess serum levels of immunoglobulins and to establish its relationship with severity of community-acquired pneumonia (CAP) and clinical outcome. [...]
2016 - 10.1136/bmjresp-2016-000152
BMJ Open Respiratory Research, Vol. 3 (november 2016)
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5 p, 474.6 KB |
Passive smoking at home is a risk factor for community-acquired pneumonia in older adults : a population-based case-control study
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Almirall i Pujol, Jordi (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Serra-Prat, Mateu (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Bolibar i Ribas, Ignasi (Institut d'Investigació Biomèdica Sant Pau) ;
Palomera, Elisabet (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Roig, Jordi (Roig Zárate) (Hospital Nostra Senyora de Meritxell (Principat d'Andorra)) ;
Hospital, Imma (Institut Català de la Salut) ;
Carandell, Eugenia (IB-SALUT Balears) ;
Agustí, Mercè (Institut Català de la Salut) ;
Ayuso, Pilar (INSALUD) ;
Estela, Andreu (IB-SALUT Balears) ;
Torres, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Universitat Autònoma de Barcelona.
Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva
2014 14 years of age. 1003 participants who had never smoked were recruited. Risk factors for CAP, including home exposure to passive smoking, were registered. All new cases of CAP in a well-defined population were consecutively recruited during a 12-month period. A population-based case-control study was designed to assess risk factors for CAP, including home exposure to passive smoking. All new cases of CAP in a well-defined population were consecutively recruited during a 12-month period. The subgroup of never smokers was selected for the present analysis. The study sample included 471 patients with CAP and 532 controls who had never smoked. The annual incidence of CAP was estimated to be 1.14 cases×10 -3 inhabitants in passive smokers and 0.90×10 −3 in non-passive smokers (risk ratio (RR) 1.26; 95% CI 1.02 to 1.55) in the whole sample. In participants ≥65 years of age, this incidence was 2.50×10 −3 in passive smokers and 1.69×10 −3 in non-passive smokers (RR 1.48, 95% CI 1.08 to 2.03). In this last age group, the percentage of passive smokers in cases and controls was 26% and 18.1%, respectively (p=0.039), with a crude OR of 1.59 (95% CI 1.02 to 2.38) and an adjusted (by age and sex) OR of 1.56 (95% CI 1.00 to 2.45). Passive smoking at home is a risk factor for CAP in older adults (65 years or more) - 10.1136/bmjopen-2014-005133
BMJ open, Vol. 4 (june 2014)
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