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13 p, 347.6 KB Prediction of week 4 virological response in hepatitis C for making decision on triple therapy : the Optim study / Romero-Gómez, Manuel (Hospital de Valme (Sevilla)) ; Turnes, Juan (Complejo Hospitalario de Pontevedra) ; Ampuero, Javier (Hospital de Valme (Sevilla)) ; Oyagüez, Itziar (Pharmacoeconomics & Outcomes Research IBeria (Madrid)) ; Cuenca, Beatriz (Hospital Universitario Infanta Cristina (Madrid)) ; Gonzalez-Garcia, Juan (Hospital Universitario La Paz (Madrid)) ; Muñoz-Molina, Belén (Roche Farma) ; Aguilar, Rocio (Fisevi (Sevilla)) ; Leal, Sandra (Fisevi (Sevilla)) ; Planas Vilà, Ramon (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Garcia-Samaniego, Javier (Hospital Carlos III (Madrid)) ; Diago, Moises (Consorci Hospital General Universitari (Valencia)) ; Crespo, Javier (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Calleja, Jose Luis (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ; Casado, Miguel Angel (Pharmacoeconomics & Outcomes Research IBeria (Madrid)) ; Solà Lamoglia, Ricard (Hospital del Mar (Barcelona, Catalunya))
Background: Virological response to peginterferon + ribavirin (P+R) at week 4 can predict sustained virological response (SVR). While patients with rapid virological response (RVR) do not require triple therapy, patients with a decline <1log10 IU/ml HCVRNA (D1L) should have treatment discontinued due to low SVR rate. [...]
2015 - 10.1371/journal.pone.0122613
PloS one, Vol. 10, No 3 (March 2015) , p. e0122613  

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