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Resultats globals: 5 registres trobats en 0.02 segons.
Articles, 5 registres trobats
Articles 5 registres trobats  
1.
18 p, 3.4 MB Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection / Barmada, Anis (Department of Medical Genetics. University of Cambridge) ; Handfield, Louis-François (Wellcome Sanger Institute (Regne Unit)) ; Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Arutyunyan, Anna (Wellcome Sanger Institute (Regne Unit)) ; Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ; Hoo, Regina (Wellcome Sanger Institute (Regne Unit)) ; Porter, Tarryn (Wellcome Sanger Institute (Regne Unit)) ; Oszlanczi, Agnes (Wellcome Sanger Institute (Regne Unit)) ; Richardson, Laura (Wellcome Sanger Institute (Regne Unit)) ; Calero-Nieto, Fernando (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ; Wilson, Nicola K. (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ; Marchese, Domenica (Centre de Regulació Genòmica) ; Sancho-Serra, Carmen (Wellcome Sanger Institute. Wellcome Genome Campus) ; Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Presas-Rodríguez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ruiz-Sanmartin, Adolfo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Munera-Campos, Mónica (Institut Germans Trias i Pujol) ; Carrascosa, José Manuel (Institut Germans Trias i Pujol) ; Göttgens, Berthold (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ; Heyn, Holger (Universitat Pompeu Fabra) ; Prigmore, Elena (Wellcome Sanger Institute (Regne Unit)) ; Casafont-Solé, Ivette (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Solanich, Xavier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sánchez-Cerrillo, Idelfonso (Department of Immunology. Hospital Universitario La Princesa) ; González-Álvaro, Isidoro (Rheumatology Service. Hospital Universitario La Princesa) ; Raimondo, Maria Gabriella (Deutsches Zentrum Immuntherapie. Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen) ; Ramming, Andreas (Deutsches Zentrum Immuntherapie. Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen) ; Martin, Javier (Instituto de Parasitología y Biomedicina "López-Neyra") ; Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vento-Tormo1, Roser (Wellcome Sanger Institute. Wellcome Genome Campus) ; Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. [...]
2024 - 10.1002/eji.202350633
European Journal of Immunology, Vol. 54 Núm. 1 (january 2024) , p. 2350633  
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2.
11 p, 4.8 MB Methylome and transcriptome profiling of giant cell arteritis monocytes reveals novel pathways involved in disease pathogenesis and molecular response to glucocorticoids / Estupiñán-Moreno, Elkyn (Instituto de Parasitología y Biomedicina "López-Neyra") ; Ortiz-Fernández, Lourdes (Instituto de Parasitología y Biomedicina "López-Neyra") ; Li, Tianlu (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Hernández-Rodríguez, José (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ; Terron-Camero, Laura Carmen (Instituto de Parasitología y Biomedicina "López-Neyra") ; Prieto-González, Sergio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Espígol-Frigolé, Georgina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Cid, María Cinta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Márquez, Ana (Instituto de Investigación Sanitaria de Granada) ; Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Martín, Javier (Instituto de Parasitología y Biomedicina "López-Neyra")
Objectives Giant cell arteritis (GCA) is a complex systemic vasculitis mediated by the interplay between both genetic and epigenetic factors. Monocytes are crucial players of the inflammation occurring in GCA. [...]
2022 - 10.1136/annrheumdis-2022-222156
Annals of the rheumatic diseases, Vol. 81 Núm. 9 (january 2022) , p. 1290-1300  
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3.
18 p, 9.8 MB Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses / Rodríguez-Ubreva, J. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Arutyunyan, A. (University of Cambridge) ; Bonder, M.J. (German Cancer Research Center) ; Del Pino-Molina, L. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; Clark, S.J. (Babraham Institute) ; de la Calle-Fabregat, Carlos (Institut d'Investigació Biomèdica de Bellvitge) ; Garcia-Alonso, L. (CeWellcome Sanger Institute) ; Handfield, L.F. (Wellcome Trust Sanger Institute (Regne Unit)) ; Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ; Krueger, F. (Babraham Institute) ; Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Rodríguez-Cortez, V.C. (Institut d'Investigació Biomèdica de Bellvitge) ; Polanski, K. (Wellcome Trust Sanger Institute (Regne Unit)) ; Mamanova, L. (Wellcome Trust Sanger Institute (Regne Unit)) ; van Dongen, S. (Wellcome Trust Sanger Institute (Regne Unit)) ; Kiselev, V.Y. (Wellcome Trust Sanger Institute (Regne Unit)) ; Martínez-Saavedra, M.T. (Hospital Universitario de Gran Canaria Dr. Negrín) ; Heyn, Holger (Universitat Pompeu Fabra) ; Martín, Javier (Instituto de Parasitología y Biomedicina "López-Neyra") ; Warnatz, K. (University of Freiburg) ; López-Granados, E. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; Rodríguez-Gallego, C. (University Fernando Pessoa) ; Stegle, O. (Wellcome Trust Sanger Institute (Regne Unit)) ; Kelsey, G. (Babraham Institute) ; Vento Tormo, Roser (University of Cambridge) ; Ballestar, Esteban (East China Normal University) ; Universitat Autònoma de Barcelona
Common variable immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency, displays impaired terminal B-cell differentiation and defective antibody responses. Incomplete genetic penetrance and ample phenotypic expressivity in CVID suggest the participation of additional pathogenic mechanisms. [...]
2022 - 10.1038/s41467-022-29450-x
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 1779  
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4.
17 p, 3.1 MB Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci / Li, Tianlu (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ortiz-Fernández, Lourdes (Instituto de Parasitología y Biomedicina "López-Neyra") ; Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ; Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Javierre, B. M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; López-Isac, E. (Instituto de Parasitología y Biomedicina "López-Neyra") ; Guillén-Del-Castillo, A. (Hospital Universitari Vall d'Hebron) ; Simeón-Aznar, C. P. (Hospital Universitari Vall d'Hebron) ; Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Martín, Javier (Instituto de Parasitología y Biomedicina "López-Neyra") ; Universitat Autònoma de Barcelona
Background: Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the principle drivers of pathogenesis. [...]
2020 - 10.1186/s13073-020-00779-6
Genome Medicine, Vol. 12 Núm. 1 (25 2020) , p. 81  
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5.
13 p, 1.4 MB Novel miRNA-mRNA interactions conserved in essential cancer pathways / Andrés-León, Eduardo (Instituto de Biomedicina de Sevilla) ; Cases, Ildefonso (REDgene Bioinformatics, Sevilla) ; Alonso, Sergio (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Rojas, Ana M. (Instituto de Biomedicina de Sevilla) ; Universitat Autònoma de Barcelona
Cancer is a complex disease in which unrestrained cell proliferation results in tumour development. Extensive research into the molecular mechanisms underlying tumorigenesis has led to the characterization of oncogenes and tumour suppressors that are key elements in cancer growth and progression, as well as that of other important elements like microRNAs. [...]
2017 - 10.1038/srep46101
Scientific reports, Vol. 7 (2017) , p. 1-13  
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