Home > Search Results: Appelhans, Dietmar
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Results overview: Found 4 records in 0.02 seconds.
Articles, 4 records found
Articles 4 records found  
1.
9 p, 1.5 MB In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer's disease transgenic mice using synchrotron-based infrared imaging / Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ; Álvarez-Marimon, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Aso, Ester (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Carmona, Margarita (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Klementieva, Oxana (Lund University. Department of Experimental Medical Science) ; Appelhans, Dietmar (Leibniz Institute of Polymer Research) ; Ferrer, Isidro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer Disease. In situ identification of early-stage amyloid aggregates in Alzheimer's disease is relevant for their importance as potential targets for effective drugs. [...]
2021 - 10.1038/s41598-021-96379-4
Scientific reports, Vol. 11 (September 2021) , art. 18368  
Detailed record - Creative Commons
2.
1 p, 745.1 KB Retraction Note : In situ structural characterization of early amyloid aggregates in Alzheimer's disease transgenic mice and Octodon degus / Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ; Álvarez-Marimon, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Aso, Ester (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Carmona, Margarita (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Klementieva, Oxana (Lund University. Medical Microspectroscopy Research Group, Department of Experimental Medical Science) ; Appelhans, Dietmar (Leibniz Institute of Polymer Research) ; Ferrer, Isidro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
2020 - 10.1038/s41598-020-76208-w
Scientific reports, Vol. 10 (november 2020)  
Detailed record - Creative Commons
3.
10 p, 2.4 MB In situ structural characterization of early amyloid aggregates in Alzheimer's disease transgenic mice and Octodon degus / Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ; Álvarez Marimon, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Aso, Ester (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Carmona, Margarita (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Klementieva, Oxana (Lund University) ; Appelhans, Dietmar (Leibniz Institute of Polymer Research) ; Ferrer, Isidro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer's disease. In situ identification of early-stage amyloid aggregates in Alzheimer's disease is relevant for their importance as potential targets for effective drugs. [...]
2020 - 10.1038/s41598-020-62708-2
Scientific reports, Vol. 10 (april 2020)  
Detailed record - Creative Commons
4.
12 p, 3.3 MB Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection / Aso, Ester (ALBA Laboratori de Llum de Sincrotró) ; Martinsson, Isak (Wallenberg Neuroscience Center) ; Appelhans, Dietmar (Leibniz Institute of Polymer Research Dresden) ; Effenberg, Christiane (Leibniz Institute of Polymer Research Dresden) ; Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ; Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Gouras, Gunnar (Wallenberg Neuroscience Center) ; Ferrer, Isidro (Hospital Universitari de Bellvitge) ; Klementieva, Oxana (Wallenberg Neuroscience Center)
Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical and biomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(propylene imine) core and maltose-histidine shell (G4HisMal) assessing if maltose-histidine shell can improve the biocompatibility and the ability to cross the blood-brain barrier, and second, to investigate the potential of G4HisMal to protect Alzheimer disease transgenic mice from memory impairment. [...]
2019 - 10.1016/j.nano.2019.01.010
Nanomedicine, Vol. 17 (April 2019) , p. 198-209  
Detailed record - Creative Commons

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