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Protein-only Nanoparticles for T Cell Expansion and Activation
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Fornt Suñé, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lázaro Bermejo, Gonzalo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gil Garcia, Marcos (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Aran, Andrea (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Garcia Pardo, Javier (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Martí, Mercè (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
The in vitro expansion and activation of T cells utilizing synthetic nanosized artificial antigen presenting cells (aAPCs) have emerged as a promising technique for cancer treatment. Although diverse nanomaterials have been explored as aAPC scaffolds, protein-only nanoparticles have been largely overlooked, despite their high designability and biocompatibility. [...]
2024 -  10.1021/acsanm.4c00698
ACS applied nano materials, Vol. 7 Núm. 6 (22 2024) , p. 6669-6680
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14 p, 952.1 KB |
Decrease in climatic disequilibrium associated with climate change and species abundance shifts in Mediterranean plant communities
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Pérez Navarro, María Ángeles (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Lloret Maya, Francisco (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Ogaya Inurrigarro, Romà (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Estiarte, Marc (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Peñuelas, Josep (Centre de Recerca Ecològica i d'Aplicacions Forestals)
Climate change induces changes in plant communities according to species' climatic requirements. These changes can be assessed by community climatic disequilibrium (CD), which corresponds to the difference between the climate inferred from the climatic requirements of the species in a community (community-inferred climate, CIC) and the local observed climate. [...]
2023 - 10.1111/1365-2745.14233
Journal of Ecology, Vol. 112, Issue 2 (February 2024) p. 291-304
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63 p, 25.7 MB |
A draft human pangenome reference
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Liao, Wen-Wei (Washington University School of Medicine) ;
Asri, Mobin (University of California) ;
Ebler, Jana (Heinrich Heine University) ;
Doerr, Daniel (Heinrich Heine University) ;
Haukness, Marina (University of California) ;
Hickey, Glenn (University of California) ;
Lu, Shuangjia (Yale University School of Medicine) ;
Lucas, Julian K. (University of California) ;
Monlong, Jean (University of California) ;
Abel, Haley J. (Washington University School of Medicine) ;
Buonaiuto, Silvia (Consiglio Nazionale delle Ricerche. Istituto di Genetica e Biofisica) ;
Chang, Xian H. (University of California) ;
Cheng, Haoyu (Harvard Medical School) ;
Chu, Justin (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Colonna, Vincenza (University of Tennessee Health Science Center) ;
Eizenga, Jordan (University of California) ;
Feng, Xiaowen (Harvard Medical School) ;
Fischer, Christian (University of Tennessee Health Science Center) ;
Fulton, Robert S. (Washington University School of Medicine) ;
Garg, Shilpa (Technical University of Denmark) ;
Groza, Cristian (McGill University) ;
Guarracino, Andrea (Tecnopolo umano. Centro di ricerca sulla genomica) ;
Harvey, William T. (University of Washington School of Medicine) ;
Heumos, Simon (University of Tübingen) ;
Howe, Kerstin (Wellcome Trust Sanger Institute (Regne Unit)) ;
Jain, Miten (Northeastern University (USA)) ;
Lu, Tsung-Yu (University of Southern California) ;
Markello, Charles (University of California) ;
Martin, Fergal J. (Wellcome Genome Campus (UK)) ;
Mitchell, Matthew W. (Coriell Institute for Medical Research (USA)) ;
Munson, Katherine M. (University of Washington School of Medicine) ;
Mwaniki, Moses Njagi (Università di Pisa) ;
Novak, Adam M. (University of California) ;
Olsen, Hugh E. (University of California) ;
Pesout, Trevor (University of California) ;
Porubsky, David (University of Washington School of Medicine) ;
Prins, Pjotr (University of Tennessee Health Science Center) ;
Sibbesen, Jonas A. (University of Copenhagen) ;
Sirén, Jouni (University of California) ;
Tomlinson, Chad (Washington University School of Medicine) ;
Villani, Flavia (University of Tennessee Health Science Center) ;
Vollger, Mitchell R. (University of Washington School of Medicine) ;
Antonacci-Fulton, Lucinda L. (Washington University School of Medicine) ;
Baid, Gunjan (Google (USA)) ;
Baker, Carl A. (University of Washington School of Medicine) ;
Belyaeva, Anastasiya (Google (USA)) ;
Billis, Konstantinos (Wellcome Genome Campus (UK)) ;
Carroll, Andrew (Google (USA)) ;
Chang, Pi-Chuan (Google (USA)) ;
Cody, Sarah (Washington University School of Medicine) ;
Cook, Daniel E. (Google (USA)) ;
Cook-Deegan, Robert M. (Arizona State University) ;
Cornejo, Omar E. (University of California) ;
Diekhans, Mark (University of California) ;
Ebert, Peter (Heinrich Heine University) ;
Fairley, Susan (Wellcome Genome Campus (UK)) ;
Fedrigo, Olivier (The Rockefeller University) ;
Felsenfeld, Adam L. (National Institutes of Health (USA)) ;
Formenti, Giulio (The Rockefeller University) ;
Frankish, Adam (Wellcome Genome Campus (UK)) ;
Gao, Yan (The Children's Hospital of Philadelphia) ;
Garrison, Nanibaa' A. (University of California) ;
Giron, Carlos Garcia (Wellcome Genome Campus (UK)) ;
Green, Richard E. (Dovetail Genomics) ;
Haggerty, Leanne (Wellcome Genome Campus (UK)) ;
Hoekzema, Kendra (University of Washington School of Medicine) ;
Hourlier, Thibaut (Wellcome Genome Campus (UK)) ;
Ji, Hanlee P. (Stanford University School of Medicine) ;
Kenny, Eimear E. (Icahn School of Medicine at Mount Sinai) ;
Koenig, Barbara A. (University of California) ;
Kolesnikov, Alexey (Google (USA)) ;
Korbel, Jan O. (European Molecular Biology Laboratory) ;
Kordosky, Jennifer (University of Washington School of Medicine) ;
Koren, Sergey (National Institutes of Health (USA)) ;
Lee, HoJoon (Stanford University School of Medicine) ;
Lewis, Alexandra P. (University of Washington School of Medicine) ;
Magalhães, Hugo (Heinrich Heine University) ;
Marco-Sola, Santiago (Universitat Autònoma de Barcelona. Departament d'Arquitectura de Computadors i Sistemes Operatius) ;
Marijon, Pierre (Heinrich Heine University) ;
McCartney, Ann (National Institutes of Health (USA)) ;
McDaniel, Jennifer (National Institute of Standards and Technology (USA)) ;
Mountcastle, Jacquelyn (The Rockefeller University) ;
Nattestad, Maria (Google (USA)) ;
Nurk, Sergey (National Institutes of Health (USA)) ;
Olson, Nathan D. (National Institute of Standards and Technology (USA)) ;
Popejoy, Alice B. (University of California) ;
Puiu, Daniela (Johns Hopkins University) ;
Rautiainen, Mikko (National Institutes of Health (USA)) ;
Regier, Allison A. (Washington University School of Medicine) ;
Rhie, Arang (National Institutes of Health (USA)) ;
Sacco, Samuel (University of California) ;
Sanders, Ashley D. (Max Delbrück Center for Molecular Medicine in the Helmholtz Association) ;
Schneider, Valerie A. (National Institutes of Health (USA)) ;
Schultz, Baergen I. (National Institutes of Health (USA)) ;
Shafin, Kishwar (Google (USA)) ;
Smith, Michael W. (National Institutes of Health (USA)) ;
Sofia, Heidi J. (National Institutes of Health (USA)) ;
Abou Tayoun, Ahmad N. (Mohammed Bin Rashid University of Medicine and Health Sciences) ;
Thibaud-Nissen, Françoise (National Institutes of Health (USA)) ;
Tricomi, Francesca Floriana (Wellcome Genome Campus (UK)) ;
Wagner, Justin (National Institute of Standards and Technology (USA)) ;
Walenz, Brian (National Institutes of Health (USA)) ;
Wood, Jonathan M. D. (Wellcome Trust Sanger Institute (Regne Unit)) ;
Zimin, Aleksey V. (Johns Hopkins University) ;
Bourque, Guillaume (Kyoto University) ;
Chaisson, Mark (University of Southern California) ;
Flicek, Paul (Wellcome Genome Campus (UK)) ;
Phillippy, Adam M. (National Institutes of Health (USA)) ;
Zook, Justin M. (National Institute of Standards and Technology (USA)) ;
Eichler, Evan E. (Howard Hughes Medical Institute) ;
Haussler, David (Howard Hughes Medical Institute) ;
Wang, Ting (Washington University School of Medicine) ;
Jarvis, Erich (The Rockefeller University) ;
Miga, Karen H. (University of California) ;
Garrison, Erik (University of Tennessee Health Science Center) ;
Marschall, Tobias (Heinrich Heine University) ;
Hall, Ira M. (Yale University School of Medicine) ;
Li, Heng (Harvard Medical School) ;
Paten, Benedict (University of California)
Here the Human Pangenome Reference Consortium presents a first draft of the human pangenome reference. The pangenome contains 47 phased, diploid assemblies from a cohort of genetically diverse individuals1. [...]
2023 - 10.1038/s41586-023-05896-x
Nature, Vol. 617 (May 2023) , p. 312-324
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12 p, 12.0 MB |
Amyloid Fibrils Formed by Short Prion-Inspired Peptides Are Metalloenzymes
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Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Díaz-Caballero, Marta (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Peccati, Francesca (Centre de Recerca Cooperativa en Biociències) ;
Roldán-Martín, Lorena (Universitat Autònoma de Barcelona. Departament de Química) ;
Sodupe Roure, Mariona (Universitat Autònoma de Barcelona. Departament de Química) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Enzymes typically fold into defined 3D protein structures exhibiting a high catalytic efficiency and selectivity. It has been proposed that the earliest enzymes may have arisen from the self-assembly of short peptides into supramolecular amyloid-like structures. [...]
2023 - 10.1021/acsnano.3c04164
ACS nano, Vol. 17, Issue 17 (September 2023) , p. 16968-16979
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25 p, 5.2 MB |
Hybrid Gold Nanorod-Based Nanoplatform with Chemo and Photothermal Activities for Bimodal Cancer Therapy
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Arellano-Galindo, Lilia (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Villar-Alvarez, Eva (Institut Català de Nanociència i Nanotecnologia) ;
Varela, Alejandro (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Figueroa, Valeria (Universidad de Guadalajara. Departamento de Ingeniería Química) ;
Fernandez-Vega, Javier (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Cambón, Adriana (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Prieto, Gerardo (Universidade de Santiago de Compostela. Departamento de Física Aplicada) ;
Barbosa, Silvia (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Taboada, Pablo (Universidade de Santiago de Compostela. Departamento de Física de Partículas)
Metal nanoparticles (NPs), particularly gold nanorods (AuNRs), appear as excellent platforms not only to transport and deliver bioactive cargoes but also to provide additional therapeutic responses for diseased cells and tissues and/or to complement the action of the carried molecules. [...]
2022 - 10.3390/ijms232113109
International journal of molecular sciences, Vol. 23, Issue 21 (October 2022) , art. 13109
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47 p, 5.4 MB |
pH-responsive self-assembly of amyloid fibrils for dual hydrolase-oxidase reactions
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Díaz-Caballero, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Navarro, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Nuez-Martínez, Miquel (Institut de Ciència de Materials de Barcelona) ;
Peccati, Francesca (Basque Research and Technology Alliance) ;
Rodríguez Santiago, Luis (Universitat Autònoma de Barcelona. Departament de Química) ;
Sodupe Roure, Mariona (Universitat Autònoma de Barcelona. Departament de Química) ;
Teixidor, Francesc (Institut de Ciència de Materials de Barcelona) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
There is an increasing interest in synthetic systems that can execute bioinspired chemical reactions without requiring the complex structures that characterize enzymes in their components. The hierarchical self-assembly of peptides provides a means to create catalytic microenvironments. [...]
2021 - 10.1021/acscatal.0c03093
ACS catalysis, Vol. 11, Issue 2 (January 2021) , p. 595-607
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27 p, 394.1 KB |
Politicising proximity : radical municipalism as a strategy in crisis
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Roth, Laura (Universitat Oberta de Catalunya) ;
Russell, Bertie (Universitat Autònoma de Barcelona) ;
Thompson, Matthew (Cardiff University)
As new municipalism comes of age, prefixes proliferate: from democratic and autonomist to post-growth and care municipalisms. How do all these variegations relate to each other and to the wider movement of which they claim a part? What does all this conceptual creativity amount to, epistemologically and politically? How can we distill the most salient lessons for the further development of theory and practice in the years ahead? This article is our attempt to answer such questions and to define more precisely the contours of this emerging field of praxis. [...]
2023 - 10.1177/00420980231173825
Urban Studies, 2023
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12 p, 11.3 MB |
Influence of the surface chemistry of metal-organic polyhedra in their assembly into ultrathin films for gas separation
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Tejedor, Inés (Universidad de Zaragoza. Departamento de Química Física) ;
Andrés, Miguel A. (Instituto de Ciencia de Materiales de Aragón) ;
Carné-Sánchez, Arnau (Institut Català de Nanociència i Nanotecnologia) ;
Arjona, Mónica (Universidad de Zaragoza. Departamento de Química Física) ;
Pérez-Miana, Marta (Universidad de Zaragoza. Departamento de Ingeniería Química y Tecnologías del Medio Ambiente) ;
Sanchez-Lainez, Javier (Instituto de Nanociencia y Materiales de Aragón) ;
Coronas, Joaquin (Instituto de Nanociencia y Materiales de Aragón) ;
Fontaine, Philippe (Synchrotron SOLEIL) ;
Goldmann, Michel (Synchrotron SOLEIL) ;
Roubeau, Olivier (Instituto de Nanociencia y Materiales de Aragón) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Gascón, Ignacio (Universidad de Zaragoza. Departamento de Química Física)
The formation of ultrathin films of Rh-based porous metal-organic polyhedra (Rh-MOPs) by the Langmuir-Blodgett method has been explored. Homogeneous and dense monolayer films were formed at the air-water interface either using two different coordinatively alkyl-functionalized Rh-MOPs (HRhMOP(diz)and HRhMOP(oiz)) or by in situ incorporation of aliphatic chains to the axial sites of dirhodium paddlewheels of another Rh-MOP (OHRhMOP) at the air-liquid interface. [...]
2022 - 10.1021/acsami.2c06123
ACS applied materials & interfaces, Vol. 14, issue 23 (June 2022) , p. 27495-27506
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20 p, 3.6 MB |
Improved high-quality genome assembly and annotation of pineapple (Ananas comosus) cultivar md2 revealed extensive haplotype diversity and diversified frs/frf gene family
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Yow, Ashley (North Carolina State University. Department of Horticultural Science) ;
Bostan, Hamed (North Carolina State University. Plants for Human Health Institute) ;
Castanera, Raúl (Centre de Recerca en Agrigenòmica) ;
Ruggieri, Valentino (Biomeets Consulting (Barcelona)) ;
Mengist, Mengist F. (North Carolina State University. Plants for Human Health Institute) ;
Curaba, Julien (North Carolina State University. Plants for Human Health Institute) ;
Young, Roberto (Standard Fruit de Honduras. Research Department of Dole) ;
Gillitt, Nicholas (David H. Murdock Research Institute) ;
Iorizzo, Massimo (North Carolina State University. Plants for Human Health Institute)
Pineapple (Ananas comosus (L. ) Merr. ) is the second most important tropical fruit crop globally, and 'MD2' is the most important cultivated variety. A high-quality genome is important for molecular-based breeding, but available pineapple genomes still have some quality limitations. [...]
2022 - 10.3390/genes13010052
Genes, Vol. 13, Issue 1 (January 2022) , art. 52
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