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14 p, 1.0 MB |
MAGNIMS recommendations for harmonization of MRI data in MS multicenter studies
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De Stefano, Nicola (Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy) ;
Battaglini, Marco (University of Siena) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Cortese, Rosa (University of Siena) ;
Zhang, Jian (University of Siena) ;
Oesingmann, Niels (UK Biobank Stockport) ;
Prados Carrasco, Ferran (Universitat Oberta de Catalunya) ;
Rocca, Maria A. (Vita-Salute San Raffaele University) ;
Valsasina, Paola (IRCCS San Raffaele Scientific Institute (Milà, Itàlia)) ;
Vrenken, Hugo (MS Center Amsterdam) ;
Gandini Wheeler-Kingshott, Claudia A. M. (University of Pavia) ;
Filippi, Massimo (IRCCS San Raffaele Scientific Institute (Milà, Itàlia)) ;
Barkhof, Frederik (MS Center Amsterdam) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
There is an increasing need of sharing harmonized data from large, cooperative studies as this is essential to develop new diagnostic and prognostic biomarkers. In the field of multiple sclerosis (MS), the issue has become of paramount importance due to the need to translate into the clinical setting some of the most recent MRI achievements. [...]
2022 -  10.1016/j.nicl.2022.102972
NeuroImage, Vol. 34 (february 2022)
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13 p, 1.2 MB |
Progression of regional grey matter atrophy in multiple sclerosis
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Eshaghi, Arman (University College London. Department of Computer Science) ;
Marinescu, Razvan V (University College London. Department of Computer Science) ;
Young, Alexandra L. (University College London. Department of Computer Science) ;
Firth, Nicholas C. (University College London. Department of Computer Science) ;
Prados Carrasco, Ferran (University College London. Department of Medical Physics and Bioengineering) ;
Jorge Cardoso, M. (University College London. Department of Medical Physics and Bioengineering) ;
Tur, Carmen (University College London. Faculty of Brain Sciences) ;
De Angelis, Floriana (University College London. Faculty of Brain Sciences) ;
Cawley, Niamh (University College London. Faculty of Brain Sciences) ;
Brownlee, Wallace J. (University College London. Faculty of Brain Sciences) ;
De Stefano, Nicola (University of Siena (Itàlia). Department of Medicine, Surgery and Neuroscience) ;
Laura Stromillo, M. (University of Siena (Itàlia). Department of Medicine, Surgery and Neuroscience) ;
Battaglini, Marco (University of Siena (Itàlia). Department of Medicine, Surgery and Neuroscience) ;
Ruggieri, Serena (University of Rome Sapienza. Department of Neurology and Psychiatry) ;
Gasperini, Claudio (San Camillo Forlanini Hospital) ;
Filippi, Massimo (Vita-Salute San Raffaele University (Milà, Itàlia)) ;
Rocca, Maria A. (Vita-Salute San Raffaele University (Milà, Itàlia)) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Geurts, Jeroen J. G. (Amsterdam UMC. University Medical Center) ;
Vrenken, Hugo (MS Center Amsterdam. Department of Radiology and Nuclear Medicine) ;
Wottschel, Viktor (MS Center Amsterdam. Department of Radiology and Nuclear Medicine) ;
Leurs, Cyra E. (MS Center Amsterdam. Department of Radiology and Nuclear Medicine) ;
Uitdehaag, Bernard (MS Center Amsterdam. Department of Radiology and Nuclear Medicine) ;
Pirpamer, Lukas (Medical University of Graz (Graz, Àustria)) ;
Enzinger, Christian (Medical University of Graz (Graz, Àustria)) ;
Ourselin, Sebastien (University College London Hospitals) ;
Gandini Wheeler-Kingshott, Claudia A. M (IRCCS Mondino Foundation (Pavia, Itàlia)) ;
Chard, Declan (University College London Hospitals) ;
Thompson, Alan J. (University College London. Faculty of Brain Sciences) ;
Barkhof, Frederik (MS Center Amsterdam. Department of Radiology and Nuclear Medicine) ;
Alexander, Daniel C.. (University College London. Department of Computer Science) ;
Ciccarelli, Olga (University College London Hospitals) ;
Universitat Autònoma de Barcelona
See Stankoff and Louapre (doi:) for a scientific commentary on this article. Grey matter atrophy in multiple sclerosis affects certain areas preferentially. Eshaghi et al. use a data-driven computational model to predict the order in which regions atrophy, and use this sequence to stage patients. [...]
2018 - 10.1093/brain/awy088
Brain, Vol. 141 (may 2018) , p. 1665-1677
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10 p, 1.4 MB |
Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI
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Amiri, Houshang (Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands) ;
de Sitter, Alexandra (Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands) ;
Bendfeldt, Kerstin (Medical Image Analysis Center (MIAC AG) Basel, Switzerland) ;
Battaglini, Marco (Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy) ;
Gandini Wheeler-Kingshott, Claudia A. M. (NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, UK) ;
Calabrese, Massimiliano (Multiple Sclerosis Centre, Neurology Section, Department of Neurosciences, Biomedicine and Movements, University of Verona, Italy) ;
Geurts, Jeroen J. G. (Amsterdam UMC. University Medical Center) ;
Rocca, Maria A. (Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Enzinger, Christian (Department of Neurology & Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria) ;
De Stefano, Nicola (Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy) ;
Filippi, Massimo (Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy) ;
Rovira, Álex (Hospital Universitari Vall d'Hebron) ;
Barkhof, Frederik (University College London. Institutes of Neurology & Healthcare Engineering) ;
Vrenken, Hugo (Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands) ;
Universitat Autònoma de Barcelona
Atrophy of the brain grey matter (GM) is an accepted and important feature of multiple sclerosis (MS). However, its accurate measurement is hampered by various technical, pathological and physiological factors. [...]
2018 - 10.1016/j.nicl.2018.04.023
NeuroImage, Vol. 19 (april 2018) , p. 466-475
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12 p, 1.5 MB |
MAGNIMS consensus recommendations on the use of brain and spinal cord atrophy measures in clinical practice
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Sastre-Garriga, Jaume (Centre d'Esclerosi Mútiple de Catalunya (Cemcat)) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Battaglini, Marco (University of Siena. Department of Medicine, Surgery and Neuroscience) ;
Rocca, Maria A. (IRCCS San Raffaele Scientific Institute (Milà, Itàlia). Institute of Experimental Neurology) ;
Ciccarelli, Olga (University College London Hospitals. National Institute for Health Research Biomedical Research Centre) ;
Enzinger, Christian (Medical University of Graz. Department of Neurology and Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology) ;
Wuerfel, Jens (University of Basel. Medical Image Analysis Center (MIAC AG) and Department of Biomedical Engineering) ;
Sormani, Maria P. (IRCCS, Ospedale Policlinico San Martino, Genoa) ;
Barkhof, Frederik (University College London. Institutes of Neurology and Healthcare Engineering) ;
Yousry, Tarek A. (University College London Hospitals National Hospital for Neurology and Neurosurgery, University College London Institute of Neurology. Lysholm Department of Neuroradiology) ;
De Stefano, Nicola (University of Siena. Department of Medicine, Surgery and Neuroscience) ;
Tintoré, Mar (Centre d'Esclerosi Mútiple de Catalunya (Cemcat)) ;
Filippi, Massimo (Vita-Salute San Raffaele University) ;
Gasperini, Claudio (San Camillo Forlanini Hospital) ;
Kappos, Ludwig (University Hospital Basel (Basilea, Suïssa)) ;
Río, Jordi (Universitat Autònoma de Barcelona) ;
Frederiksen, Jette (University of Copenhagen) ;
Palace, Jackie (University of Oxford. Nuffield Department of Clinical Neurosciences) ;
Vrenken, Hugo (Amsterdam Neuroscience, MS Center Amsterdam, Department of Radiology and Nuclear Medicine, Amsterdam UMC) ;
Montalban, Xavier (University of Toronto. Division of Neurology, St Michael's Hospital) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona ;
Hospital Universitari Vall d'Hebron ;
Centre d'Esclerosi Mútiple de Catalunya (Cemcat)
Early evaluation of treatment response and prediction of disease evolution are key issues in the management of people with multiple sclerosis (MS). In the past 20 years, MRI has become the most useful paraclinical tool in both situations and is used clinically to assess the inflammatory component of the disease, particularly the presence and evolution of focal lesions - the pathological hallmark of MS. [...]
2020 - 10.1038/s41582-020-0314-x
Nature Reviews. Neurology, Vol. 16 (february 2020) , p. 171-182
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13 p, 862.2 KB |
Deep gray matter volume loss drives disability worsening in multiple sclerosis
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Eshaghi, Arman (University College London) ;
Prados Carrasco, Ferran (University College London Hospitals) ;
Brownlee, Wallace J. (University College London) ;
Altmann, Daniel R. (London School of Hygiene & Tropical Medicine) ;
Tur, Carmen (University College London) ;
Cardoso, M. Jorge (University College London) ;
De Angelis, Floriana (University College London) ;
van de Pavert, Steven H. (University College London) ;
Cawley, Niamh (University College London) ;
De Stefano, Nicola (University of Siena) ;
Stromillo, M. Laura (University of Siena) ;
Battaglini, Marco (University of Siena) ;
Ruggieri, Serena (University of Rome Sapienza) ;
Gasperini, Claudio (San Camillo Forlanini Hospital) ;
Filippi, Massimo (Vita-Salute San Raffaele University) ;
Rocca, Maria A. (Vita-Salute San Raffaele University) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Vrenken, Hugo (VU University Medical Centre) ;
Leurs, Cyra E. (Amsterdam UMC. University Medical Center) ;
Killestein, Joep (Amsterdam UMC. University Medical Center) ;
Pirpamer, Lukas (Medical University of Graz) ;
Enzinger, Christian (Medical University of Graz) ;
Ourselin, Sebastien (University College London Hospitals) ;
Wheeler-Kingshott, Claudia A. M. Gandini (C. Mondino National Neurological Institute) ;
Chard, Declan (University College London Hospitals) ;
Thompson, Alan J. (University College London) ;
Alexander, Daniel C.. (University College London) ;
Barkhof, Frederik (VU University Medical Centre) ;
Ciccarelli, Olga (University College London Hospitals) ;
Universitat Autònoma de Barcelona
Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. [...]
2018 - 10.1002/ana.25145
Annals of neurology, Vol. 83, Issue 2 (February 2018) , p. 210-222
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