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13 p, 844.6 KB A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis / Marler, Katharine J. M. (MRC Centre for Developmental Neurobiology) ; Becker-Barroso, Elena (MRC Centre for Developmental Neurobiology) ; Martínez, Albert (Institut de Recerca Biomèdica) ; Llovera, Marta (Institut de Recerca Biomèdica de LLeida) ; Wentzel, Corinna (MRC Centre for Developmental Neurobiology) ; Poopalasundaram, Subathra (MRC Centre for Developmental Neurobiology) ; Hindges, Robert (MRC Centre for Developmental Neurobiology) ; Soriano García, Eduardo (Institut de Recerca Biomèdica) ; Comella i Carnicé, Joan Xavier, 1963- (Institut de Recerca Biomèdica de LLeida) ; Drescher, Uwe (MRC Centre for Developmental Neurobiology)
Toward understanding topographically specific branching of retinal axons in their target area, we have studied the interaction between neurotrophin receptors and members of the Eph family. TrkB and its ligand BDNF are uniformly expressed in the retina and tectum, respectively, and exert a branch-promoting activity, whereas EphAs and ephrinAs are expressed in gradients in retina and tectum and can mediate a suppression of axonal branching. [...]
2008 - 10.1523/JNEUROSCI.1915-08.2008
The Journal of neuroscience, Vol. 28, No. 48 (Nov. 2008) , p. 12700-12712  

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