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1.
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20 p, 3.7 MB |
A Review of Fifteen Years Developing Computational Tools to Study Protein Aggregation
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Pintado-Grima, Carlos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bárcenas, Oriol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bartolomé-Nafría, Andrea (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Fornt Suñé, Marc (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona
The presence of insoluble protein deposits in tissues and organs is a hallmark of many human pathologies. In addition, the formation of protein aggregates is considered one of the main bottlenecks to producing protein-based therapeutics. [...]
2023 -  10.3390/biophysica3010001
Biophysica, Vol. 3 Núm. 1 (January 2023)
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2.
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11 p, 4.1 MB |
A mathematical model of fibrinogen-mediated erythrocyte-erythrocyte adhesion
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Lopes, Catarina Sousa (Universidade de Lisboa. Instituto de Medicina Molecular) ;
Curty, Juliana (University of Coimbra. Department of Physics) ;
Carvalho, Filomena A. (Universidade de Lisboa. Instituto de Medicina Molecular) ;
Hernández-Machado, Aurora (Centre de Recerca Matemàtica) ;
Kinoshita, Koji (University of Southern Denmark. Department of Molecular Medicine) ;
Santos, Nuno C. (Universidade de Lisboa. Instituto de Medicina Molecular) ;
Travasso, Rui D. M. (University of Coimbra. Department of Physics)
Erythrocytes are deformable cells that undergo progressive biophysical and biochemical changes affecting the normal blood flow. Fibrinogen, one of the most abundant plasma proteins, is a primary determinant for changes in haemorheological properties, and a major independent risk factor for cardiovascular diseases. [...]
2023 - 10.1038/s42003-023-04560-4
Communications Biology, Vol. 6 (February 2023) , art. 192
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3.
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15 p, 1.7 MB |
Effect of cryoprotectant concentration on bovine oocyte permeability and comparison of two membrane permeability modelling approaches
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Garcia Martinez, Tania (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Mogas Amorós, Teresa (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Mullen, Steven F. (COOK Medical) ;
Martínez-Rodero, Iris (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Gulieva, Ramila E. (Oregon State University. School of Chemical, Biological and Environmental Engineering) ;
Higgins, Adam Z. (Oregon State University. School of Chemical, Biological and Environmental Engineering)
The plasma membrane permeability to water and cryoprotectant (CPA) significantly impacts vitrification efficiency of bovine oocytes. Our study was designed to determine the concentration-dependent permeability characteristics for immature (GV) and mature (MII) bovine oocytes in the presence of ethylene glycol (EG) and dimethyl sulphoxide (MeSO), and to compare two different modeling approaches: the two parameter (2P) model and a nondilute transport model. [...]
2021 - 10.1038/s41598-021-94884-0
Scientific reports, Vol. 11 (july 2021)
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4.
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19 p, 5.7 MB |
The evolutionary advantage of an aromatic clamp in plant family 3 glycoside exo-hydrolases
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Luang, Sukanya (University of Adelaide) ;
Fernández-Luengo Flores, Xavier (Universitat Autònoma de Barcelona. Departament de Química) ;
Nin-Hill, Alba (Universitat de Barcelona. Departament de Química Inorgànica i Orgànica) ;
Streltsov, Victor A. (University of Melbourne. The Florey Institute) ;
Schwerdt, Julian G. (University of Adelaide) ;
Alonso-Gil, Santiago (Universitat de Barcelona. Departament de Química Inorgànica i Orgànica) ;
Ketudat Cairns, James R. (Suranaree University of Technology. School of Chemistry) ;
Pradeau, Stéphanie (Université Grenoble Alpes. Centre de Recherches sur les Macromolécules Végétales) ;
Fort, Sebastien (Université Grenoble Alpes. Centre de Recherches sur les Macromolécules Végétales) ;
Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química) ;
Masgrau, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rovira, Carme (Institució Catalana de Recerca i Estudis Avançats) ;
Hrmova, Maria (Huaiyin Normal University)
In the barley β-D-glucan glucohydrolase, a glycoside hydrolase family 3 (GH3) enzyme, the Trp286/Trp434 clamp ensures β-D-glucosides binding, which is fundamental for substrate hydrolysis during plant growth and development. [...]
2022 - 10.1038/s41467-022-33180-5
Nature communications, Vol. 13 (September 2022) , art. 5577
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5.
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16 p, 3.6 MB |
Polarimetric observables for the enhanced visualization of plant diseases
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Rodríguez, Carla (Universitat Autònoma de Barcelona. Departament de Física) ;
Garcia-Caurel, Enrique (Institut Polytechnique de Paris) ;
Garnatje, Teresa (Institut Botànic de Barcelona) ;
Serra i Ribas, Mireia (Universitat Autònoma de Barcelona. Departament de Física) ;
Luque, Jordi (Institut de Recerca i Tecnologia Agroalimentàries) ;
Campos Coloma, Juan (Universitat Autònoma de Barcelona. Departament de Física) ;
Lizana Tutusaus, Ángel (Universitat Autònoma de Barcelona. Departament de Física)
This paper highlights the potential of using polarimetric methods for the inspection of plant diseased tissues. We show how depolarizing observables are a suitable tool for the accurate discrimination between healthy and diseased tissues due to the pathogen infection of plant samples. [...]
2022 - 10.1038/s41598-022-19088-6
Scientific reports, Vol. 12 (August 2022) , art. 14743
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6.
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9 p, 1.5 MB |
In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer's disease transgenic mice using synchrotron-based infrared imaging
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Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ;
Álvarez-Marimon, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Aso, Ester (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Carmona, Margarita (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Klementieva, Oxana (Lund University. Department of Experimental Medical Science) ;
Appelhans, Dietmar (Leibniz Institute of Polymer Research) ;
Ferrer, Isidro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer Disease. In situ identification of early-stage amyloid aggregates in Alzheimer's disease is relevant for their importance as potential targets for effective drugs. [...]
2021 - 10.1038/s41598-021-96379-4
Scientific reports, Vol. 11 (September 2021) , art. 18368
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7.
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14 p, 4.4 MB |
α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
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Santos, Jaime (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Gracia González, Pablo (Universidad de Zaragoza. Instituto de Biocomputación y Física de Sistemas Complejos) ;
Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Peña Díaz, Samuel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pujols Pujol, Jordi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cremades, Nunilo (Universidad de Zaragoza. Instituto de Biocomputación y Física de Sistemas Complejos) ;
Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
α-Synuclein aggregation is a key driver of neurodegeneration in Parkinson's disease and related syndromes. Accordingly, obtaining a molecule that targets α-synuclein toxic assemblies with high affinity is a long-pursued objective. [...]
2021 - 10.1038/s41467-021-24039-2
Nature communications, Vol. 12 (June 2021) , art. 3752
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8.
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9.
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12 p, 1.7 MB |
New applanation tonometer for myopic patients after laser refractive surgery
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Iglesias, María (Instituto Universitario Barraquer) ;
Yebra, Francisco (Universidade de Vigo. Departamento de Física Aplicada) ;
Kudsieh, Bachar (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Laiseca, Andrea (Instituto Universitario Barraquer) ;
Pereira dos Santos, Cristina Maria (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Nadal Reus, Jeroni (Instituto Universitario Barraquer) ;
Barraquer, Rafael I. (Rafael Ignasi) (Instituto Universitario Barraquer) ;
Casaroli-Marano, Ricardo Pedro (Hospital Clínic i Provincial de Barcelona)
This study assesses the agreement between intraocular pressure (IOP) measurements taken with the Goldmann applanation tonometer (GAT) and a new experimental applanation tonometer with a convexly shaped apex (CT) after laser myopic refractive surgery. [...]
2020 - 10.1038/s41598-020-64013-4
Scientific reports, Vol. 10 (April 2020) , art. 7053
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