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10 p, 1.2 MB A new serotonin 5-HT6 receptor antagonist with procognitive activity : importance of a halogen bond interaction to stabilize the binding / González-Vera, Juan A. (Universidad Complutense de Madrid.Departamento de Química Orgánica) ; Medina, Rocio A. (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Martín-Fontecha, Mar (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; González Wong, Angel (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; De La Fuente, Tania (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Vázquez-Villa, Henar (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; García-Cárceles, Javier (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Botta, Joaquín (University of East Anglia. School of Pharmacy (Norwich, Regene Unit)) ; McCormick, Peter J. (University of East Anglia. School of Pharmacy (Norwich, Regene Unit)) ; Benhamú, Bellida (Universidad Complutense de Madrid. Departamento de Química Orgánica) ; Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; López-Rodríguez, Maria L. (Universidad Complutense de Madrid. Departamento de Química Orgánica)
Serotonin 5-HT6 receptor has been proposed as a promising therapeutic target for cognition enhancement though the development of new antagonists is still needed to validate these molecules as a drug class for the treatment of Alzheimer's disease and other pathologies associated with memory deficiency. [...]
2017 - 10.1038/srep41293
Scientific Reports, Vol. 7 (2017) , art. 41293  

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