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11 p, 1.0 MB |
Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin
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Blasco, Natividad (Cell Signaling and Apoptosis group, Universitat de Lleida - IRBLleida, Lleida, Spain) ;
Cámara, Yolanda (Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona and CIBERER, Barcelona, Spain) ;
Núñez, Estefanía (Cardiovascular Proteomics group, Spanish National Center for Cardiovascular Research (CNIC) and CIBERCV Madrid, Spain) ;
Beà, Aida (Cell Signaling and Apoptosis group, Universitat de Lleida - IRBLleida, Lleida, Spain) ;
Barés, Gisel (Cell Signaling and Apoptosis group, Universitat de Lleida - IRBLleida, Lleida, Spain) ;
Forné, Carles (Universitat de Lleida, Institut de Recerca Biomèdica de Lleida (IRBLleida)) ;
Ruíz-Meana, Marisol (Cardiovascular Diseases Research Group, VHIR and CIBERCV, Barcelona, Spain) ;
Girón, Cristina (Cell Signaling and Apoptosis group, Universitat de Lleida - IRBLleida, Lleida, Spain) ;
Barba, Ignasi (Cardiovascular Diseases Research Group, VHIR and CIBERCV, Barcelona, Spain) ;
García-Arumí, Elena (Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona and CIBERER, Barcelona, Spain) ;
García Dorado, David (Cardiovascular Diseases Research Group, VHIR and CIBERCV, Barcelona, Spain) ;
Vázquez, Jesús (Cardiovascular Proteomics group, Spanish National Center for Cardiovascular Research (CNIC) and CIBERCV Madrid, Spain) ;
Martí Seves, Ramon (Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona and CIBERER, Barcelona, Spain) ;
Llovera, Marta (Cell Signaling and Apoptosis group, Universitat de Lleida - IRBLleida, Lleida, Spain) ;
Sanchis, Daniel (Cell Signaling and Apoptosis group, Universitat de Lleida - IRBLleida, Lleida, Spain)
The endonuclease G gene (Endog), which codes for a mitochondrial nuclease, was identified as a determinant of cardiac hypertrophy. How ENDOG controls cardiomyocyte growth is still unknown. Thus, we aimed at finding the link between ENDOG activity and cardiomyocyte growth. [...]
2018 -  10.1016/j.redox.2018.02.021
Redox biology, Vol. 16 (march 2018) , p. 146-156
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23 p, 4.0 MB |
MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria
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Dalla Rosa, Ilaria (MRC Mill Hill Laboratory, London, United Kingdom) ;
Cámara, Yolanda (Vall d'Hebron Institut de Recerca. Laboratori de Trastorns Mitocondrials) ;
Durigon, Romina (MRC Mill Hill Laboratory) ;
Moss, Chloe F. (MRC Mill Hill Laboratory) ;
Vidoni, Sara (MRC Mitochondrial Biology Unit, Wellcome Trust-MRC Building) ;
Akman, Gokhan (MRC Mill Hill Laboratory) ;
Hunt, Lilian (MRC Mill Hill Laboratory) ;
Johnson, Mark A. (MRC Mitochondrial Biology Unit, Wellcome Trust-MRC Building) ;
Grocott, Sarah (Mitochondrial Genetics Group, Nuffield Department of Obstetrics and Gynaecology, Women's Centre, The John Radcliffe Hospital, Oxford, United Kingdom) ;
Wang, Liya (Department of Anatomy, Physiology and Biochemistry, The Swedish University of Agricultural Sciences, Biomedical Center) ;
Thorburn, David R. (Murdoch Childrens Research Institute and University of Melbourne Department of Paediatrics, Royal Children's Hospital) ;
Hirano, Michio (Department of Neurology, Columbia University Medical Center, New York, New York, United States of America) ;
Poulton, Joanna (Mitochondrial Genetics Group, Nuffield Department of Obstetrics and Gynaecology, Women's Centre, The John Radcliffe Hospital) ;
Taylor, Robert W. (Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, The Medical School, Newcastle upon Tyne) ;
Elgar, Greg (MRC Mill Hill Laboratory) ;
Martí Seves, Ramon (Biomedical Network Research Centre on Rare Diseases, Instituto de Salud Carlos III) ;
Voshol, Peter (Institute of Metabolic Science, University of Cambridge) ;
Holt, Ian J. (MRC Mill Hill Laboratory, London) ;
Spinazzola, Antonella (MRC Mill Hill Laboratory) ;
Universitat Autònoma de Barcelona
MPV17 is a mitochondrial inner membrane protein whose dysfunction causes mitochondrial DNA abnormalities and disease by an unknown mechanism. Perturbations of deoxynucleoside triphosphate (dNTP) pools are a recognized cause of mitochondrial genomic instability; therefore, we determined DNA copy number and dNTP levels in mitochondria of two models of MPV17 deficiency. [...]
2016 - 10.1371/journal.pgen.1005779
PLoS Genetics, Vol. 12 (january 2016)
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