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22 p, 8.7 MB |
Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer
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Waryah, Charlene (University of Western Australia) ;
Cursons, Joseph (Monash University, Australia) ;
Foroutan, Momeneh (Department of Biochemistry and Molecular Biology. Monash University, Australia) ;
Pflueger, Christian (University of Western Australia) ;
Wang, Edina (University of Western Australia) ;
Molania, Ramyar (University of Melbourne, Australia) ;
Woodward, Eleanor (Harry Perkins Institute of Medical Research, Australia) ;
Sorolla, Anabel (University of Western Australia) ;
Wallis, Christopher (University of Western Australia) ;
Moses, Colette (University of Amsterdam, The Netherlands) ;
Glas, Irina (Harry Perkins Institute of Medical Research, Australia) ;
Magalhães, Leandro (University of Pará, Brazil) ;
Thompson, Erik W. (Queensland University of Technology, Brisbane, Australia) ;
Fearnley, Liam G. (University of Melbourne, Australia) ;
Chaffer, Christine L. (St Vincent's Clinical School. UNSW Medicine, Australia) ;
Davis, Melissa (University of Melbourne, Australia) ;
Papenfuss, Anthony T. (University of Melbourne, Australia) ;
Redfern, Andrew (University of Western Australia) ;
Lister, Ryan (The University of Western Australia) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Blancafort, Pilar (University of Western Australia)
Epithelial-mesenchymal transition (EMT) is a reversible transcriptional program invoked by cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of EMT, driving disease recurrence in poor-outcome triple negative breast cancers (TNBCs). [...]
2023 -  10.1002/advs.202301802
Advanced science, Vol. 10 Núm. 22 (august 2023)
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13 p, 551.6 KB |
Possible EU futures for CRISPR-edited plants : Little margin for optimism?
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Escajedo San-Epifanio, Leire (Universidad del País Vasco. Departamento de Derecho Público, Ciencias Histórico-Jurídicas e Historia del Pensamiento Político) ;
Filibi, Igor (Universidad del País Vasco. Departamento de Derecho Público, Ciencias Histórico-Jurídicas e Historia del Pensamiento Político) ;
Lasa López, Ainhoa (Universidad del País Vasco. Departamento de Derecho Público, Ciencias Histórico-Jurídicas e Historia del Pensamiento Político) ;
Puigdomènech, Pere 1948- (Centre de Recerca en Agrigenòmica) ;
Uncetabarrenechea Larrabe, Javier (Universidad del País Vasco. Departamento de Derecho Público, Ciencias Histórico-Jurídicas e Historia del Pensamiento Político)
This article addresses the scenarios that may be encountered by the first application for pre-market approval of a CRISPR-edited plant in the EU. Two alternative scenarios are considered in the short and medium term. [...]
2023 - 10.3389/fpls.2023.1141455
Frontiers in plant science, Vol. 14 (March 2023) , art. 1141455
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11 p, 1.5 MB |
Costa Rican consumer perceptions of gene-editing
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Macall, Diego Maximiliano (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Madrigal-Pana, Johnny (University of Costa Rica) ;
Smyth, Stuart J. (University of Saskatchewan. Department of Agricultural and Resource Economics) ;
Gatica Arias, Andrés (University of Costa Rica)
Costa Rica's rice production, a large determinant of the country's food security, is being negatively impacted by frequently increasing periods of intense drought. Costa Rican scientists have applied CRISPR/Cas9 to develop drought resistant rice varieties they believe the country's rice producers could benefit from. [...]
2023 - 10.1016/j.heliyon.2023.e19173
Heliyon, Vol. 9, Issue 8 (August 2023) , art. e19173
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14 p, 2.6 MB |
Analysis of Cancer Genomic Amplifications Identifies Druggable Collateral Dependencies within the Amplicon
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Pons, Guillem (Hospital Universitari Vall d'Hebron) ;
Gallo-Oller, Gabriel (Hospital Universitari Vall d'Hebron) ;
Navarro Barea, Natalia (Hospital Universitari Vall d'Hebron) ;
Zarzosa, Patricia (Hospital Universitari Vall d'Hebron) ;
Sansa-Girona, Júlia (Hospital Universitari Vall d'Hebron) ;
García-Gilabert, Lia (Hospital Universitari Vall d'Hebron) ;
Magdaleno, Ainara (Hospital Universitari Vall d'Hebron) ;
Segura, Miguel F. (Hospital Universitari Vall d'Hebron) ;
Sánchez de Toledo Codin, Josep (Hospital Universitari Vall d'Hebron) ;
Gallego, Soledad (Hospital Universitari Vall d'Hebron) ;
Moreno, Lucas (Hospital Universitari Vall d'Hebron) ;
Roma, Josep (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
The identification of novel therapeutic targets for specific cancer molecular subtypes is crucial for the development of precision oncology. In the last few years, CRISPR/Cas9 screens have accelerated the discovery and validation of new targets associated with different tumor types, mutations, and fusions. [...]
2023 - 10.3390/cancers15061636
Cancers, Vol. 15 (march 2023)
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5.
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15 p, 3.3 MB |
ABO gene editing for the conversion of blood type A to universal type O in Rh donor-derived human-induced pluripotent stem cells
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Petazzi, Paolo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Miquel-Serra, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Huertas, Sergio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González, Cecilia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Boto, Neus (Laboratorio de Immunohematología (Barcelona)) ;
Muñiz-Diaz, Eduardo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sevilla, Ana (Universitat de Barcelona) ;
Nogués Gálvez, Núria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
The limited availability of red cells with extremely rare blood group phenotypes is one of the global challenges in transfusion medicine that has prompted the search for alternative self-renewable pluripotent cell sources for the in vitro generation of red cells with rare blood group types. [...]
2022 - 10.1002/ctm2.1063
Clinical and Translational Medicine, Vol. 12 (october 2022)
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19 p, 13.1 MB |
Effects of impaired steryl ester biosynthesis on tomato growth and developmental processes
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Burciaga-Monge, Alma (Centre de Recerca en Agrigenòmica) ;
López-Tubau, Joan Manel (Centre de Recerca en Agrigenòmica) ;
Laibach, Natalie (Centre de Recerca en Agrigenòmica) ;
Deng, Cuiyun (Centre de Recerca en Agrigenòmica) ;
Ferrer, Albert (Centre de Recerca en Agrigenòmica) ;
Altabella Artigas, Teresa (Centre de Recerca en Agrigenòmica)
Steryl esters (SE) are stored in cytoplasmic lipid droplets and serve as a reservoir of sterols that helps to maintain free sterols (FS) homeostasis in cell membranes throughout plant growth and development, and provides the FS needed to meet the high demand of these key plasma membrane components during rapid plant organ growth and expansion. [...]
2022 - 10.3389/fpls.2022.984100
Frontiers in plant science, Vol. 13 (September 2022) , art. 984100
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8.
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11 p, 2.6 MB |
Knock-Out of CmNAC-NOR Affects Melon Climacteric Fruit Ripening
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Liu, Bin (Centre de Recerca en Agrigenòmica) ;
Santo Domingo, Miguel (Centre de Recerca en Agrigenòmica) ;
Mayobre, Carlos (Centre de Recerca en Agrigenòmica) ;
Martín-Hernández, Ana Montserrat (Centre de Recerca en Agrigenòmica) ;
Pujol Abajo, Marta (Centre de Recerca en Agrigenòmica) ;
Garcia-Mas, Jordi (Centre de Recerca en Agrigenòmica)
Fruit ripening is an important process that affects fruit quality. A QTL in melon, ETHQV6. 3, involved in climacteric ripening regulation, has been found to be encoded by CmNAC-NOR, a homologue of the tomato NOR gene. [...]
2022 - 10.3389/fpls.2022.878037
Frontiers in plant science, Vol. 13 (June 2022) , art. 878037
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17 p, 19.5 MB |
Impact of the epigenetically regulated hoxa-5 gene in neural differentiation from human adipose-derived stem cells
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Hernández, R. (Universidad de Granada) ;
Jiménez-Luna, Cristina (Universidad de Granada) ;
Ortiz, Raúl (Universidad de Granada. Departamento de Anatomía y Embriología) ;
Setién, Fernando (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
López, Miguel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Perazzoli, Gloria (Universidad de Granada) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Berdasco, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Prados, José (Universidad de Granada. Departamento de Anatomía y Embriología) ;
Melguizo, Consolación (Universidad de Granada. Departamento de Anatomía y Embriología)
Human adipose-derived mesenchymal stem cells (hASCs) may be used in some nervous system pathologies, although obtaining an adequate degree of neuronal differentiation is an important barrier to their applicability. [...]
2021 - 10.3390/biology10080802
Biology, Vol. 10 Núm. 8 (august 2021) , p. 802
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14 p, 1.4 MB |
A novel Transposable element-derived microRNA participates in plant immunity to rice blast disease
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Campo, Sonia (Centre de Recerca en Agrigenòmica) ;
Sánchez-Sanuy, Ferran (Centre de Recerca en Agrigenòmica) ;
Gómez-Ariza, Jorge (Centre de Recerca en Agrigenòmica) ;
Baldrich, Patricia (Centre de Recerca en Agrigenòmica) ;
Campos-Soriano, Lidia (Centre de Recerca en Agrigenòmica) ;
Soto-Suárez, Mauricio (Centre de Recerca en Agrigenòmica) ;
San Segundo, Blanca (Centre de Recerca en Agrigenòmica)
MicroRNAs (miRNAs) are small non-coding RNAs that direct post-transcriptional gene silencing in plant development and stress responses through cleavage or translational repression of target mRNAs. Here, we report the identification and functional characterization of a new member of the miR812 family in rice (named as miR812w) involved in disease resistance. [...]
2021 - 10.1111/pbi.13592
Plant Biotechnology Journal, Vol. 19, Issue 9 (September 2021) , p. 1798-1811
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