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1.
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15 p, 2.7 MB |
ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
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Mensali, Nadia (Department of Cellular Therapy. Oslo University Hospital) ;
Köksal, Hakan (Oslo University Hospital) ;
Joaquina, Sandy (Oslo University Hospital) ;
Wernhoff, Patrick (Oslo University Hospital) ;
Casey, Nicholas P. (Oslo University Hospital) ;
Romecín, Paola Alejandra (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Panisello, Carla (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez, René (Instituto de Salud Carlos III) ;
Vimeux, Lene (Université de Paris) ;
Juzeniene, Asta (Oslo University Hospital) ;
Myhre, Marit R. (Oslo University Hospital) ;
Fåne, Anne (Oslo University Hospital) ;
Castilla-Ramirez, Carolina (Virgen del Rocio University Hospital) ;
Maggadottir, Solrun Melkork (Oslo University Hospital) ;
Duru, Adil Doganay (Nova Southeastern University) ;
Georgoudaki, Anna-Maria (Department of Oncology-Pathology. Karolinska Institutet) ;
Grad, Iwona (Oslo University Hospital) ;
Maturana, Andrés Daniel (Nagoya University) ;
Gaudernack, Gustav (Department of Cancer Immunology. Oslo University Hospital) ;
Kvalheim, Gunnar (Department of Cellular Therapy. Oslo University Hospital) ;
Carcaboso, Angel M. (Institut de Recerca Sant Joan de Déu) ;
De Álava, Enrique (Universidad de Sevilla) ;
Donnadieu, Emma (Université de Paris) ;
Bruland, Øyvind S (University of Oslo) ;
Menendez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Inderberg, Else Marit (Oslo University Hospital) ;
Wälchli, Sébastien (Oslo University Hospital)
Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising as in some other cancer types due to intra-tumor heterogeneity and considerable off-target expression of the potentially targetable proteins. [...]
2023 -  10.1038/s41467-023-39097-x
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 3375
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2.
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15 p, 3.3 MB |
Methuosis Contributes to Jaspine-B-Induced Cell Death
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Bielsa, Núria (Institut de Química Avançada de Catalunya) ;
Casasampere, Mireia (Institut de Química Avançada de Catalunya) ;
Abad, José Luis (Institut de Química Avançada de Catalunya) ;
Enrich, Carlos (Universitat de Barcelona. Departament de Biomedicina) ;
Delgado, Antonio (Institut de Química Avançada de Catalunya) ;
Fabriàs, Gemma (Institut de Química Avançada de Catalunya) ;
Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Casas, Josefina (Institut de Química Avançada de Catalunya)
Methuosis is a type of programmed cell death in which the cytoplasm is occupied by fluid-filled vacuoles that originate from macropinosomes (cytoplasmic vacuolation). A few molecules have been reported to behave as methuosis inducers in cancer cell lines. [...]
2022 - 10.3390/ijms23137257
International journal of molecular sciences, Vol. 23 Núm. 13 (2022) , p. 7257
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3.
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14 p, 3.9 MB |
Combined analysis of miR-200 family and its significance for breast cancer
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Fontana, Andrea (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Barbano, Raffaela (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Dama, Elisa (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Pasculli, Barbara (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Rendina, Michelina (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Morritti, Maria Grazia (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Melocchi, Valentina (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Castelvetere, Marina (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Valori, Vanna Maria (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Ravaioli, Sara (Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS) ;
Bravaccini, Sara (Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS) ;
Ciuffreda, Luigi (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Graziano, Paolo (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Maiello, Evaristo (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Copetti, Massimiliano (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Fazio, Vito Michele (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bianchi, Fabrizio (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Parrella, Paola (Fondazione IRCCS Casa Sollievo della Sofferenza)
While the molecular functions of miR-200 family have been deeply investigated, a role for these miRNAs as breast cancer biomarkers remains largely unexplored. In the attempt to clarify this, we profiled the miR-200 family members expression in a large cohort of breast cancer cases with a long follow-up (H-CSS cohort) and in TCGA-BRCA cohort. [...]
2021 - 10.1038/s41598-021-82286-1
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 2980
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4.
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10 p, 2.9 MB |
Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody-Drug Conjugates in Breast Cancer
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Duro-Sánchez, Santiago (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Nadal-Serrano, Mercedes (Centro de Investigación Biomédica en Red de Cáncer) ;
Lalinde-Gutiérrez, Marta. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Arenas, Enrique J (Centro de Investigación Biomédica en Red de Cáncer) ;
Bernadó Morales, Cristina (Centro de Investigación Biomédica en Red de Cáncer) ;
Morancho, Beatriz (Centro de Investigación Biomédica en Red de Cáncer) ;
Escorihuela, Marta (Vall d'Hebron Institut d'Oncologia) ;
Pérez-Ramos, Sandra (Vall d'Hebron Institut d'Oncologia) ;
Escrivá-de-Romaní, Santiago (Vall d'Hebron Institut d'Oncologia) ;
Gandullo-Sánchez, Lucía (Vall d'Hebron Institut d'Oncologia) ;
Pandiella, Atanasio (Instituto de Biología Molecular y Celular del Cáncer (Barcelona)) ;
Esteve-Codina, Anna (Universitat Pompeu Fabra) ;
Rodilla, Verónica (Vall d'Hebron Institut d'Oncologia) ;
Dijcks, Fred .A. (Byondis B.V. (Holanda)) ;
Dokter, Wim .H.A. (Byondis B.V. (Holanda)) ;
Cortés, Javier (Vall d'Hebron Institut d'Oncologia) ;
Saura, Cristina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Arribas, Joaquín V (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Antibody-drug conjugates (ADC) are antineoplastic agents recently introduced into the antitumor arsenal. T-DM1, a trastuzumab-based ADC that relies on lysosomal processing to release the payload, is approved for HER2-positive breast cancer. [...]
2022 - 10.1158/0008-5472.CAN-22-0787
Cancer research, Vol. 82 Núm. 24 (12 2022) , p. 4670-4679
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5.
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14 p, 2.4 MB |
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects
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Baquero, Juan Miguel (Centro Nacional de Investigaciones Oncológicas) ;
Benítez-Buelga, Carlos (Karolinska Institutet (Estocolm, Suècia)) ;
Rajagopal, Varshni (Karolinska Institutet (Estocolm, Suècia)) ;
Zhenjun, Zhao (Karolinska Institutet (Estocolm, Suècia)) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Müller, Sarah (Karolinska Institutet (Estocolm, Suècia)) ;
Hanna, Bishoy M. F. (Karolinska Institutet (Estocolm, Suècia)) ;
Loseva, Olga (Karolinska Institutet (Estocolm, Suècia)) ;
Wallner, Olov (Karolinska Institutet (Estocolm, Suècia)) ;
Michel, Maurice (Karolinska Institutet (Estocolm, Suècia)) ;
Rodriguez-Perales, Sandra (Grupo de Citogenética Molecular. Programa de Genética del Cáncer Humano. Centro Nacional de Investigaciones Oncológicas de España (Madrid)) ;
Gad, Helge (The University of Sheffield) ;
Visnes, Torkild (SINTEF Industry (Noruega)) ;
Helleday, Thomas (The University of Sheffield) ;
Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ;
Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ;
Universitat Autònoma de Barcelona
The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base excision repair (BER) pathway. Telomeres are particularly sensitive to oxidative stress (OS) which disrupts telomere homeostasis triggering genome instability. [...]
2021 - 10.1038/s41598-021-82917-7
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 3490
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6.
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11 p, 1.5 MB |
Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18
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Maher, Michael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Le Pannérer, Marguerite Marie (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cabezón, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vergara, Sara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Méndez López, Aleix (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mesa Tudel, Alba (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sorigue, Marc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Haematopoietic malignancies are frequently characterized by karyotypic abnormalities. The development of targeted drugs has been pioneered with compounds against gene products of fusion genes caused by chromosomal translocations. [...]
2021 - 10.1038/s41598-021-00623-w
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 21145
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7.
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14 p, 5.6 MB |
SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
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Romero, Octavio A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vilarrubi, Andrea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Alburquerque-Béjar, Juan Jos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gómez Moruno, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrades, Álvaro (Universidad de Granada) ;
Trastulli, Deborah (Institut d'Investigació Biomèdica de Bellvitge) ;
Pros, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Setien, Fernando (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Verdura, Sara (Institut d'Investigació Biomèdica de Bellvitge) ;
Farre, Lourdes (Institut d'Investigació Biomèdica de Bellvitge) ;
Martín-Tejera, Juan F. (Institut d'Investigació Biomèdica de Bellvitge) ;
Llabata, Paula (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Oaknin, Ana (Hospital Universitari Vall d'Hebron) ;
Saigi, María (Institut Català d'Oncologia) ;
Piulats, Josep M. (Institut Català d'Oncologia) ;
Matias-Guiu, Xavier (Institut d'Investigació Biomèdica de Bellvitge) ;
Medina, Pedro P. (Universidad de Granada) ;
Vidal, August (Parc Científic de Barcelona) ;
Villanueva, Alberto (Parc Científic de Barcelona) ;
Sanchez-Cespedes, Montse (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Despite the genetic inactivation of SMARCA4, a core component of the SWI/SNF-complex commonly found in cancer, there are no therapies that effectively target SMARCA4-deficient tumours. Here, we show that, unlike the cells with activated MYC oncogene, cells with SMARCA4 inactivation are refractory to the histone deacetylase inhibitor, SAHA, leading to the aberrant accumulation of H3K27me3. [...]
2021 - 10.1038/s41467-021-24618-3
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 4319
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8.
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14 p, 2.0 MB |
Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation
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Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bywater, M. J. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Sanij, E. (Department of Pathology. University of Melbourne) ;
Cameron, D. P. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ;
Schierding, W. (Liggins Institute. The University of Auckland) ;
Brajanovski, N. (Cancer Research Division. Peter MacCallum Cancer Centre) ;
Son, J. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ;
Sornkom, J. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ;
Hein, N. (ACRF Department of Cancer Biology and Therapeutics. John Curtin School of Medical Research. Australian National University) ;
Evers, M. (ACRF Department of Cancer Biology and Therapeutics. John Curtin School of Medical Research. Australian National University) ;
Pearson, R. B. (Department of Biochemistry and Molecular Biology. University of Melbourne) ;
McArthur, G. A. (St Vincent's Hospital (Sydney)) ;
Ganley, A. R. D. (School of Biological Sciences. The University of Auckland) ;
O'Sullivan, J. M. (Liggins Institute. The University of Auckland) ;
Hannan, R. D. (School of Biomedical Sciences. University of Queensland) ;
Poortinga, G. (St Vincent's Hospital (Sydney)) ;
Universitat Autònoma de Barcelona
The three-dimensional organization of the genome contributes to its maintenance and regulation. While chromosomal regions associate with nucleolar ribosomal RNA genes (rDNA), the biological significance of rDNA-genome interactions and whether they are dynamically regulated during disease remain unclear. [...]
2019 - 10.1038/s42003-019-0284-y
Communications Biology, Vol. 2 Núm. 1 (january 2019) , p. 39
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16 p, 2.3 MB |
SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina
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Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Thackray, J. K. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Simonet, N. G. (Institut d'Investigació Biomèdica de Bellvitge) ;
Chahar, S. (Montpellier Institute of Molecular Genetics (IGMM). CNRS. University of Montpellier) ;
Kane-Goldsmith, N. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Newkirk, S. J. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ;
Lee, S. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ;
Xing, J. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Verzi, M. P. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
An, W. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tischfield, J. A. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Serrano, L. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Universitat Autònoma de Barcelona
Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of self-propagation in the genome with potential mutagenic outcomes. How somatic cells restrict L1 activity and how this process becomes dysfunctional during aging and in cancer cells is poorly understood. [...]
2019 - 10.1093/nar/gkz519
Nucleic acids research, Vol. 47 Núm. 15 (january 2019) , p. 7870-7885
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10.
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11 p, 1.9 MB |
Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma
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Recasens-Zorzo, Clara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cardesa-Salzmann, Teresa (Hospital Clínic i Provincial de Barcelona) ;
Petazzi, Paolo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ros-Blanco, Laia (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ;
Esteve-Arenys, Anna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Clot, Guillem (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Guerrero-Hernández, Martina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rodríguez, Vanina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Soldini, Davide (Hospital Clínic i Provincial de Barcelona) ;
Valera, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Moros, Alexandra (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Climent, Fina (Hospital Universitari de Bellvitge) ;
Gonzalez-Barca, Eva (Institut Català d'Oncologia) ;
Mercadal, Santiago (Institut Català d'Oncologia) ;
Arenillas, Leonor (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Calvo, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Mate Sanz, Jose Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gutiérrez-García, Gonzalo (Hospital Clínic i Provincial de Barcelona) ;
Casanova Rigat, Isolda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mangues, Ramon 1957- (Institut d'Investigació Biomèdica Sant Pau) ;
Sanjuan-Pla, Alejandra (Hospital Universitari i Politècnic La Fe (València)) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez, Antonio (Hospital Clínic i Provincial de Barcelona) ;
Colomer, Dolors (Hospital Clínic i Provincial de Barcelona) ;
Estrada Tejedor, Roger (Universitat Ramon Llull) ;
Teixidó, Jordi (Universitat Ramon Llull) ;
Campo, Elias (Hospital Clínic i Provincial de Barcelona) ;
López-Guillermo, A. (Hospital Clínic i Provincial de Barcelona) ;
Borrell, José Ignacio (Universitat Ramon Llull) ;
Colomo, Luis (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pérez-Galán, Patricia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Roué, Gaël (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
Constitutive activation of the chemokine receptor CXCR4 has been associated with tumor progression, invasion, and chemotherapy resistance in different cancer subtypes. Although the CXCR4 pathway has recently been suggested as an adverse prognostic marker in diffuse large B-cell lymphoma, its biological relevance in this disease remains underexplored. [...]
2019 - 10.3324/haematol.2017.180505
Haematologica, Vol. 104 Núm. 4 (31 2019) , p. 778-788
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