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1.
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11 p, 3.9 MB |
Endothelium-Released Microvesicles Transport miR-126 That Induces Proangiogenic Reprogramming in Monocytes
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Arderiu, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Peña, Esther (Instituto de salud Carlos III) ;
Civit-Urgell, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
We have recently shown that in ischemic tissue, the hypoxic endothelial cells (EC) release extracellular microvesicles (EMVs) that are rich in tissue factor (TF). These TF-EMVs induce monocyte (Mo) homing to the ischemic zone, their differentiation into EC-like cells, and the formation of new blood vessels increasing tissue perfusion. [...]
2022 -  10.3389/fimmu.2022.836662
Frontiers in immunology, Vol. 13 (18 2022) , p. 836662
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2.
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14 p, 4.6 MB |
Osteogenic differentiation of adipose-derived canine mesenchymal stem cells seeded in porous calcium-phosphate scaffolds
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Herrera, David (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Lodoso-Torrecilla, Irene (Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica) ;
Ginebra, Maria-Pau (Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica) ;
Rappe, Katrin Steffanie (Universitat Autònoma de Barcelona. Departament de Cirurgia) ;
Franch, Jordi (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Engineered bone graft substitutes are a promising alternative and supplement to autologous bone grafts as treatments for bone healing impairment. Advances in human medicine extend an invitation to pursue these biomimetic strategies in animal patients, substantiated by the theory that specialized scaffolds, multipotent cells, and biological cues may be combined into a bioactive implant intended for the enhancement of tissue regeneration. [...]
2023 - 10.3389/fvets.2023.1149413
Frontiers in Veterinary Science, Vol. 10 (june 2023)
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3.
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15 p, 3.4 MB |
Disruption of NIPBL/Scc2 in Cornelia de Lange Syndrome provokes cohesin genome-wide redistribution with an impact in the transcriptome
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Garcia, Patricia (Universidad de Salamanca) ;
Fernández Hernández, Rita (Institut d'Investigació Biomèdica de Bellvitge) ;
Cuadrado, Ana (Centro Nacional de Investigaciones Oncológicas) ;
Coca, Ignacio (Genomics Laboratory (Barcelona)) ;
Gómez, Antonio (Parc Científic de Barcelona) ;
Maqueda, Maria (Institut d'Investigació Biomèdica de Bellvitge) ;
Latorre Pellicer, Ana (Universidad de Zaragoza) ;
Puisac, Beatriz (Universidad de Zaragoza) ;
Ramos, Feliciano J. (Universidad de Zaragoza) ;
Sandoval, Juan (Instituto de Investigación Sanitaria La Fe) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mosquera, José Luis (Institut d'Investigació Biomèdica de Bellvitge) ;
Rodríguez, Jairo (Genomics Laboratory (Barcelona)) ;
Pié, J. (Universidad de Zaragoza) ;
Losada, Ana (Centro Nacional de Investigaciones Oncológicas) ;
Queralt, Ethel (Instituto de Biomedicina de Valencia (IBV-CSIC)) ;
Universitat Autònoma de Barcelona
Cornelia de Lange syndrome (CdLS) is a rare disease affecting multiple organs and systems during development. Mutations in the cohesin loader, NIPBL/Scc2, were first described and are the most frequent in clinically diagnosed CdLS patients. [...]
2021 - 10.1038/s41467-021-24808-z
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 4551
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4.
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17 p, 5.1 MB |
Robust temporal map of human in vitro myelopoiesis using single-cell genomics
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Alsinet, Clara (Open Targets. Wellcome Genome Campus) ;
Primo, Maria Nascimento (Open Targets. Wellcome Genome Campus) ;
Lorenzi, Valentina (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Bello, Erica (Open Targets. Wellcome Genome Campus) ;
Kelava, Iva (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Jones, Carla P. (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Vilarrasa Blasi, Roser (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Sancho Serra, Carmen (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Knights, Andrew J. (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Park, Jong Eun (Korea Advanced Institute of Science and Technology) ;
Wyspianska, Beata S. (Immunology Research Unit. Medicines Research Centre. GlaxoSmithKline) ;
Trynka, Gosia (Open Targets. Wellcome Genome Campus) ;
Tough, David F. (Immunology Research Unit. Medicines Research Centre. GlaxoSmithKline) ;
Bassett, Andrew (Open Targets. Wellcome Genome Campus) ;
Gaffney, Daniel J. (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vento Tormo, Roser (Wellcome Sanger Institute. Wellcome Genome Campus)
Myeloid cells are central to homeostasis and immunity. Characterising in vitro myelopoiesis protocols is imperative for their use in research, immunotherapies, and understanding human myelopoiesis. Here, we generate a >470K cells molecular map of human induced pluripotent stem cells (iPSC) differentiation into macrophages. [...]
2022 - 10.1038/s41467-022-30557-4
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 2885
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14 p, 2.3 MB |
Priming human adipose-derived mesenchymal stem cells for corneal surface regeneration
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Nieto-Nicolau, Núria (Universitat de Barcelona. Departament de Biologia Cel·lular) ;
Martínez-Conesa, Eva M (Institut d'Investigació Biomèdica Sant Pau) ;
Fuentes-Julián, S. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Arnalich-Montiel, Francisco (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
García-Tuñón, I. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
De Miguel, M.P. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Casaroli-Marano, Ricardo Pedro (Institut d'Investigació Biomèdica Sant Pau)
Limbal stem cells (LSC) maintain the transparency of the corneal epithelium. Chemical burns lead the loss of LSC inducing an up-regulation of pro-inflammatory and pro-angiogenic factors, triggering corneal neovascularization and blindness. [...]
2021 - 10.1111/jcmm.16501
Journal of Cellular and Molecular Medicine, Vol. 25 Núm. 11 (june 2021) , p. 5124-5137
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16 p, 2.5 MB |
Semen Modulates Cell Proliferation and Differentiation-Related Transcripts in the Pig Peri-Ovulatory Endometrium
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Gardela Santacruz, Jaume (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Ruiz Conca, Mateo (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Wright, Dominic (Linköping University. Department of Physics, Chemistry and Biology) ;
López Béjar, Manel (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Martinez, Cristina A (Linköping University. Department of Biomedical & Clinical Sciences) ;
Rodriguez-Martinez, Heriberto (Linköping University. Department of Biomedical & Clinical Sciences) ;
Álvarez-Rodríguez, Manuel (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Homeostasis of the uterus after mating is crucial for the subsequent reproductive events. The post-mating inflammatory response is restricted to the uterus, but semen also modulates the expression of other genes involved in regulation along the female reproductive tract, including the oviduct. [...]
2022 - 10.3390/biology11040616
Biology, Vol. 11 (april 2022)
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17 p, 3.1 MB |
Probing the immune responses to nanoparticles across environmental species. A perspective of the EU Horizon 2020 project PANDORA
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Pinsino, Annalisa (Istituto per la Ricerca e l'Innovazione Biomedica (Palermo)) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Busquets-Fité, Martí (Applied Nanoparticles S.L.) ;
Canesi, Laura (Università di Genova. Dipartimento di scienze della terra, dell'ambiente e della vita) ;
Cesaroni, Paola (ALTA S.r.l.u) ;
Drobne, Damjana (Univerza V Ljubljani. Oddelek za biologijo) ;
Duschl, Albert (Paris-Lodron University Salzburg. Department of Biosciences) ;
Ewart, Marie-Ann (AvantiCell Science Ltd) ;
Gispert, Ignasi (Applied Nanoparticles S.L.) ;
Horejs-Hoeck, Jutta (Paris-Lodron University Salzburg. Department of Biosciences) ;
Italiani, Paola (Stazione Zoologica Anton Dohrn) ;
Kemmerling, Birgit (Eberhard-Karls University Tübingen. Center for Plant Molecular Biology-ZMBP) ;
Kille, Peter (Cardiff University. School of Biosciences) ;
Procházková, Petra (Institute of Microbiology of the Czech Academy of Sciences) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Spurgeon, David J. (UK Centre for Ecology and Hydrology) ;
Svendsen, Claus (UK Centre for Ecology and Hydrology) ;
Wilde, Colin J. (AvantiCell Science Ltd) ;
Boraschi, Diana (Istituto di Biochimica e Biologia Cellulare (Nàpols))
Understanding how engineered nanomaterials affect immune responses of living organisms requires a strong collaborative effort between immunologists, toxicologists, ecologists, physiologists, inorganic chemists, nanomaterial scientists and experts in law and risk management. [...]
2020 - 10.1039/d0en00732c
Environmental science. Nano, Vol. 7, issue 11 (Nov. 2020) , p. 3216-3232
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13 p, 3.9 MB |
Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
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Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Calero-Nieto, Fernando (Department of Hematology. Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. University of Cambridge) ;
Wang, X. (Department of Hematology. Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. University of Cambridge) ;
Valdés-Mas, Rafael (Dreamgenics S.L. Oviedo) ;
Gutiérrez-Agüera, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roca Ho, Heleia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ayllon, Veronica (Centro Pfizer - Universidad de Granada - Junta de Andalucía de Genómica e Investigación Oncológica) ;
Real, P. J. (Centro Pfizer - Universidad de Granada - Junta de Andalucía de Genómica e Investigación Oncológica) ;
Arambilet Mobilla, David (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Espinosa, Lluís (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Agraz-Doblás, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Varela, Ignacio (Universidad de Cantabria. Departamento de Biología Molecular) ;
De Boer, J. (University College London Great Ormond Street Institute of Child Health. Cancer Section) ;
Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gottgens, B. (Department of Hematology. Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. University of Cambridge) ;
Marschalek, Rolf (Institute of Pharmaceutical Biology. Goethe-University) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis. The developmental/pathogenic contribution of the t(4;11)-resulting MLL-AF4 (MA4) and AF4-MLL (A4M) fusions remains unclear; MA4 is always expressed in patients with t(4;11)+ B-cell acute lymphoblastic leukemia, but the reciprocal fusion A4M is expressed in only half of the patients. [...]
2019 - 10.3324/haematol.2018.202044
Haematologica, Vol. 104 Núm. 6 (2019) , p. 1189-1201
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