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9 p, 1005.0 KB |
Chronic hypogammaglobulinemia after allogeneic stem cell transplantation and their treatment with subcutanaeos inmunoglobulin in pediatric patients Hipogammaglobulinemia crónica postrasplante de precursores hematopoyéticos y su tratamiento con gammaglobulina subcutánea en pacientes pediátricos
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Serra Font, Sara (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
López-Granados, Lucía (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sisinni, Luisa (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Serna Berna, José (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Martinez-Martinez, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Fernández de Gamarra Martínez, Edurne (Institut d'Investigació Biomèdica Sant Pau) ;
de la Calle-Martín, Oscar (Institut d'Investigació Biomèdica Sant Pau) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Hypogammaglobulinemia in the first months after allogeneic hematopoietic stem cell transplantation (HSCT) is common in pediatric patients. During this phase, replacement therapy with human immunoglobulin must be administered parenterally to prevent infections. [...]
2022 -  10.1016/j.anpedi.2021.08.011
Anales de pediatría, Vol. 97 Núm. 2 (agosto 2022) , p. 103-111
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7 p, 518.4 KB |
Langerhans cell histiocytosis. Advances in pathogenesis and clinical practice Histiocitosis de células de Langerhans. Avances en la patogenia y práctica clínica
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Astigarraga, Itziar (Universidad del País Vasco) ;
García-Obregón, Susana (Universidad del País Vasco) ;
Pérez-Martínez, Antonio (Instituto de Investigación del Hospital La Paz) ;
Gutiérrez-Carrasco, Ignacio (Hospital Infantil Virgen del Rocío) ;
Santa-María, Vicente (Hospital Sant Joan de Deu) ;
Rodríguez-Vigil Iturrate, Carmen (Hospital Universitario Miguel Servet (Saragossa)) ;
Lorite Reggiori, Mikael (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Murciano Carrillo, Thais (Hospital Universitari Vall d'Hebron) ;
Torrent, Montse (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Langerhans cell histiocytosis (LCH) is a type of myeloid neoplasia that can affect different organs or tissues and exhibits substantial variability in its clinical presentation and biological behaviour, so it may mimic different diseases. [...]
2022 - 10.1016/j.anpedi.2022.05.002
Anales de pediatría, Vol. 97 Núm. 2 (agosto 2022) , p. 130.e1-130.e7
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10 p, 2.6 MB |
Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villanueva, Lorea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
González-Navarro, Europa Azucena (Department of Immunology. Hospital Clinic) ;
Juan, Manuel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Urbano-Ispizua, Álvaro (Department of Hematology. University of Barcelona) ;
Delgado, Julia (Centro de Investigación Biomedica en Red de Cancer) ;
Ortiz-Maldonado, Valetín (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Del Bufalo, Francesca (Department of Paediatric Haematology and Oncology. Bambino Gesù Children's Hospital) ;
Locatelli, Franco (Sapienza University of Rome) ;
Quintarelli, Concetta (Department of Clinical Medicine and Surgery. University of Naples Federico II) ;
Sinibaldi, Matilde (Department of Paediatric Haematology and Oncology. Bambino Gesù Children's Hospital) ;
Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Castro De Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ferrer, Gerardo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Urdinguio, Rocío G. (Universidad de Oviedo) ;
Fernandez, A.F. (Universidad de Oviedo) ;
Fraga, Mario F. (Universidad de Oviedo) ;
Bar, Diana (The Edmond and Lily Safra Children's Hospital) ;
Meir, Agustín (The Edmond and Lily Safra Children's Hospital) ;
Itzhaki, Orit (Ella Lemelbaum Institute for Immuno Oncology) ;
Besser, MichalJ. (Tel Aviv University) ;
Avigdor, Abraham (Sheba Medical Center) ;
Jacoby, Elad (Tel Aviv University) ;
Esteller, Manel (Universitat de Barcelona. Departament de Ciències Fisiològiques)
Background: Chimeric antigen receptor (CAR) T cells directed against CD19 (CART19) are effective in B-cell malignancies, but little is known about the molecular factors predicting clinical outcome of CART19 therapy. [...]
2022 - 10.1093/jnci/djab194
Journal of the National Cancer Institute, Vol. 114 Núm. 3 (january 2022) , p. 436-445
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10 p, 903.6 KB |
Outcomes in Patients with FLT3-Mutated Relapsed/ Refractory Acute Myelogenous Leukemia Who Underwent Transplantation in the Phase 3 ADMIRAL Trial of Gilteritinib versus Salvage Chemotherapy
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Perl, Alexander E. (University of Pennsylvania) ;
Larson, Richard A (University of Chicago) ;
Podoltsev, Nikolai A. (Yale School of Medicine) ;
Strickland, Stephen (Vanderbilt-Ingram Cancer Center) ;
Wang, Eunice S. (Roswell Park Comprehensive Cancer Center) ;
Atallah, Ehab (Medical College of Wisconsin) ;
Schiller, Gary J. (David Geffen School of Medicine at UCLA) ;
Martinelli, Giovanni (IRCCS Istituto Scientifico Romagnolo per lo Studio dei Tumori "Dino Amadori" IRST S.r.l) ;
Neubauer, Andreas (Universitätsklinikum Giessen und Marburg GmbH) ;
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau) ;
Montesinos, Pau (Hospital Universitari i Politècnic La Fe (València)) ;
Recher, Christian (Centre Hospitalier Universitaire de Toulouse. Institut Universitaire du Cancer de Toulouse Oncopole. Université de Toulouse 3 Paul Sabatier) ;
Yoon, Sung-Soo (Seoul National University Hospital) ;
Maeda, Yoshinobu (Okayama University Hospital) ;
Hosono, Naoko (University of Fukui) ;
Onozawa, Masahiro (Hokkaido University) ;
Kato, Takayrasu (Department of Hematology. University of Tsukuba) ;
Kim, Hee-Je (Catholic Hematology Hospital. College of Medicine. The Catholic University of Korea) ;
Hasabou, Nahla (Astellas Pharma US. Inc.) ;
Nuthethi, Rishita (Astellas Pharma US. Inc.) ;
Tiu, Ramon (Astellas Pharma US. Inc.) ;
Levis, Mark J. (Sidney Kimmel Comprehensive Cancer Center. Johns Hopkins University)
The fms-like tyrosine kinase 3 (FLT3) inhibitor gilteritinib improved the survival of patients with relapsed or refractory (R/R) FLT3-mutated acute myelogenous leukemia (AML) in the phase 3 ADMIRAL trial. [...]
2023 - 10.1016/j.jtct.2022.12.006
Transplantation and Cellular Therapy, Vol. 29 Núm. 4 (april 2023) , p. 265.e1-265.e10
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16 p, 3.4 MB |
CAR-Ts redirected against the Thomsen-Friedenreich antigen CD176 mediate specific elimination of malignant cells from leukemia and solid tumors
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Dragon, Anna Christina (Hannover Medical School) ;
Beermann, Luca Marie (Hannover Medical School) ;
Umland, Melina (Hannover Medical School) ;
Bonifacius, Agnes (Hannover Medical School) ;
Malinconico, Chiara (Hannover Medical School) ;
Ruhl, Louisa (Hannover Medical School) ;
Kehler, Patrik (Glycotope GmbH) ;
Gellert, Johanna (Glycotope GmbH) ;
Weiß, Lisa (Glycotope GmbH) ;
Mayer-Hain, Sarah (Glycotope GmbH) ;
Zimmermann, Katharina (Hannover Medical School) ;
Riese, Sebastian (Hannover Medical School) ;
Thol, F. (Department of Hematology. Hannover Medical School) ;
Beutel, Gernot (Hannover Medical School) ;
Maecker-Kolhoff, B. (Department of Pediatric Hematology and Oncology. Hannover Medical School) ;
Yamamoto, Felicitas (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Blasczyk, Rainer (Hannover Medical School) ;
Schambach, Axel (Hannover Medical School) ;
Hust, Michael (Department of Medical Biotechnology. Technical University of Braunschweig) ;
Hudecek, Michael (Department of Internal Medicine II. University Hospital of Würzburg) ;
Eiz-Vesper, Britta (Hannover Medical School) ;
Universitat Autònoma de Barcelona
Introduction: Chimeric antigen receptor-engineered T cells (CAR-Ts) are investigated in various clinical trials for the treatment of cancer entities beyond hematologic malignancies. A major hurdle is the identification of a target antigen with high expression on the tumor but no expression on healthy cells, since "on-target/off-tumor" cytotoxicity is usually intolerable. [...]
2023 - 10.3389/fimmu.2023.1219165
Frontiers in immunology, Vol. 14 (2023) , p. 1219165
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6 p, 681.8 KB |
A management model in blood, tissue and cell establishments to ensure rapid and sustainable patient access to advanced therapy medicinal products in Europe
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Delgadillo Duarte, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Kerkelä, Erja (Finnish Red Cross Blood Service (Finland)) ;
Waters, Allison (Irish Blood Transfusion Service. National Blood Centre (Ireland)) ;
van den Akker, Emile (University of Amsterdam) ;
Lechanteur, Chantal (Université de Liège) ;
Baudoux, Etienne (Université de Liège) ;
Gardiner, Nicola (St. James's Hospital (Dublín, Irlanda)) ;
De Vos, John (Hôpital Saint-Eloi (França)) ;
Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina)
Blood, tissue and cell establishments (BTCs) stand out in the management of donor selection, procurement and processing of all types of substances of human origin (SoHO). In the last decades, the framework created around BTCs, including hospitals and national health system networks, and their links to research, development and innovation organizations and agencies have spurred their involvement in the study of groundbreaking advanced therapy medicinal products (ATMP). [...]
2023 - 10.1016/j.jcyt.2023.08.001
Cytotherapy, Vol. 25 Núm. 12 (december 2023) , p. 1259-1264
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5 p, 470.9 KB |
Spanish Cell Therapy Network (TerCel) : 15 years of successful collaborative translational research
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Sánchez-Guijo, Fermín (Universidad de Salamanca) ;
García-Olmo, Damián (Universidad Autónoma de Madrid) ;
Prósper, Felipe (Universidad de Navarra) ;
Martínez, Salvador (Instituto de Neurociencias UMH-CSIC) ;
Zapata, Agustín (Universidad Complutense de Madrid) ;
Fernandez Aviles, Francesc (IiSGM-Hospital General Universitario Gregorio Marañón) ;
Toledo-Aral, Juan José (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Torres, Miguel (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Fariñas, Isabel (Universitat de València) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Labandeira-García, José Luis (Universidade de Santiago de Compostela) ;
García-Sancho, Javier (Universidad de Valladolid) ;
Moraleda, José M. (Universidad de Murcia) ;
Universitat Autònoma de Barcelona
In the current article we summarize the 15-year experience of the Spanish Cell Therapy Network (TerCel), a successful collaborative public initiative funded by the Spanish government for the support of nationwide translational research in this important area. [...]
2020 - 10.1016/j.jcyt.2019.11.001
Cytotherapy, Vol. 22 Núm. 1 (january 2020) , p. 1-5
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25 p, 5.2 MB |
Hybrid Gold Nanorod-Based Nanoplatform with Chemo and Photothermal Activities for Bimodal Cancer Therapy
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Arellano-Galindo, Lilia (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Villar-Alvarez, Eva (Institut Català de Nanociència i Nanotecnologia) ;
Varela, Alejandro (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Figueroa, Valeria (Universidad de Guadalajara. Departamento de Ingeniería Química) ;
Fernandez-Vega, Javier (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Cambón, Adriana (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Prieto, Gerardo (Universidade de Santiago de Compostela. Departamento de Física Aplicada) ;
Barbosa, Silvia (Universidade de Santiago de Compostela. Departamento de Física de Partículas) ;
Taboada, Pablo (Universidade de Santiago de Compostela. Departamento de Física de Partículas)
Metal nanoparticles (NPs), particularly gold nanorods (AuNRs), appear as excellent platforms not only to transport and deliver bioactive cargoes but also to provide additional therapeutic responses for diseased cells and tissues and/or to complement the action of the carried molecules. [...]
2022 - 10.3390/ijms232113109
International journal of molecular sciences, Vol. 23, Issue 21 (October 2022) , art. 13109
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16 p, 3.3 MB |
Smoking Suppresses the Therapeutic Potential of Adipose Stem Cells in Crohn's Disease Patients through Epigenetic Changes
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Boronat-Toscano, Albert (Hospital Universitari Joan XXIII de Tarragona) ;
Vañó, Irene (Institut d'Investigació Sanitària Pere Virgili) ;
Monfort-Ferré, Diandra (Hospital Universitari Joan XXIII de Tarragona) ;
Menacho, Margarita (Hospital Universitari Joan XXIII de Tarragona) ;
Valldosera, Gemma (Hospital Universitari Joan XXIII de Tarragona) ;
Caro, Aleidis (Hospital Universitari Joan XXIII de Tarragona) ;
Espina, Beatriz (Hospital Universitari Joan XXIII de Tarragona) ;
Mañas, Maria José (Hospital Sant Pau i Santa Tecla (Tarragona)) ;
Marti-Gallostra, Marc (Hospital Universitari Vall d'Hebron) ;
Espin-Basany, Eloy (Hospital Universitari Vall d'Hebron) ;
Saera-Vila, Alfonso (Sequentia Biotech) ;
Serena, Carolina (Institut d'Investigació Sanitària Pere Virgili) ;
Universitat Autònoma de Barcelona
Patients with Crohn's disease (CD) who smoke are known to have a worse prognosis than never-smokers and a higher risk for post-surgical recurrence, whereas patients who quit smoking after surgery have significantly lower post-operative recurrence. [...]
2023 - 10.3390/cells12071021
Cells, Vol. 12 (march 2023)
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