Home > Search Results: Chromosome segregation
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Results overview: Found 3 records in 0.03 seconds.
Articles, 3 records found
Articles 3 records found  
1.
12 p, 4.2 MB Centrosome reduction in newly-generated tetraploid cancer cells obtained by separase depletion / Galofré, Claudia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Asensio, Elena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Ubach, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Torres, Irianna M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Quintanilla, Isabel (National Institutes of Health. National Cancer Institute) ; Castells, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Camps, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Tetraploidy, a common feature in cancer, results in the presence of extra centrosomes, which has been associated with chromosome instability (CIN) and aneuploidy. Deregulation in the number of centrosomes triggers tumorigenesis. [...]
2020 - 10.1038/s41598-020-65975-1
Scientific reports, Vol. 10 (June 2020) , art. 9152  
Detailed record - Creative Commons
2.
11 p, 1.8 MB Aneuploidy in Cancer : Lessons from Acute Lymphoblastic Leukemia / Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Abad, Maria Alba (Wellcome Center for Cell Biology. University of Edinburgh) ; Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Aneuploidy, the gain or loss of chromosomes in a cell, is a hallmark of cancer. Although our understanding of the contribution of aneuploidy to cancer initiation and progression is incomplete, significant progress has been made in uncovering the cellular consequences of aneuploidy and how aneuploid cancer cells self-adapt to promote tumorigenesis. [...]
2021 - 10.1016/j.trecan.2020.08.008
Trends in Cancer, Vol. 7 Núm. 1 (january 2021) , p. 37-47  
Detailed record - Creative Commons
3.
6 p, 1.1 MB A role for the spindle assembly checkpoint in the DNA damage response / Palou, Roger (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Palou Marin, Gloria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Garcia Quintana, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Spontaneous DNA damage poses a continuous threat to genomic integrity. If unchecked, genotoxic insults result in genomic instability, a hallmark of cancer cells. In eukaryotic cells a DNA Damage Response (DDR) detects and responds to genotoxic stress, acting as an anti-cancer barrier in humans. [...]
2016 - 10.1007/s00294-016-0634-y
Current Genetics, Vol. 63, Num. 2 (August 2016) , p. 275-280  
Detailed record - Creative Commons

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