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Articles, 1 records found
Research literature, 1 records found
Articles 1 records found  
1.
16 p, 3.1 MB Neuroprotective effects of the multitarget agent AVCRI104P3 in brain of middle-aged mice / Relat, J. (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona) ; Come, J. (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona) ; Perez, B. (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona) ; Camps, P. (Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit). Faculty of Pharmacy and Food Sciences. Institute of Biomedicine (IBUB). University of Barcelona) ; Muñoz-Torrero, D. (Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit). Faculty of Pharmacy and Food Sciences. Institute of Biomedicine (IBUB). University of Barcelona) ; Badia Sancho, A. (Albert) (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona) ; Gimenez-Llort, L. (Department of Psychiatry and Forensic Medicine. Autonomous University of Barcelona) ; Clos, M.V. (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona)
Molecular factors involved in neuroprotection are key in the design of novel multitarget drugs in aging and neurodegeneration. AVCRI104P3 is a huprine derivative that exhibits potent inhibitory effects on human AChE, BuChE, and BACE-1 activities, as well as on AChE-induced and self-induced Aβ aggregation. [...]
2018 - 10.3390/ijms19092615
International Journal of Molecular Sciences, Vol. 19 Núm. 9 (april 2018) , p. 2615  

Research literature 1 records found  
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226 p, 5.1 MB Efecte dels anticolinesteràsics huprina x i avcri104p3 en els processos neurodegeneratius i d'envelliment / Relat Pardo, Júlia ; Clos Guillén, Mª Victòria, dir. ; Pérez Fernández, Belén, dir. ; Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia
Entre els diferents trastorns neurodegeneratius, la malaltia d'Alzheimer (MA) es caracteritza per la pèrdua progressiva de les funcions cognitives i l'alteració del comportament, essent el sistema colinèrgic central el principal sistema afectat. [...]
Among the different neurodegenerative disorders, Alzheimer's disease (AD) is characterized by the progressive loss of cognitive function and the altered behaviour, being the central cholinergic system the main affected. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  

See also: similar author names
2 Clos, M. Victòria
1 Clos, Manel
1 Clos, Marta
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