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Results overview: Found 7 records in 0.01 seconds.
Articles, 6 records found
Research literature, 1 records found
Articles 6 records found  
1.
30 p, 17.9 MB Revealing the Therapeutic Potential of Botulinum Neurotoxin Type A in Counteracting Paralysis and Neuropathic Pain in Spinally Injured Mice / Vacca, Valentina (IRCCS Santa Lucia Foundation, 00143 Roma, Italy; (L.M.); (F.D.A.); (D.P.)) ; Madaro, Luca (Sapienza University of Rome) ; De Angelis, Federica (IRCCS Santa Lucia Foundation (Itàlia)) ; Proietti, Daisy (Sapienza University of Rome) ; Cobianchi, Stefano (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Orsini, Tiziana (CNR-National Research Council (Itàlia)) ; Puri, Pier Lorenzo (Sanford Burnham Prebys Medical Discovery Institute (Estats Units d'Amèrica)) ; Luvisetto, Siro (CNR-National Research Council (Itàlia)) ; Pavone, Flaminia (IRCCS Santa Lucia Foundation (Itàlia)) ; Marinelli, Sara (IRCCS Santa Lucia Foundation (Itàlia))
Botulinum neurotoxin type A (BoNT/A) is a major therapeutic agent that has been proven to be a successful treatment for different neurological disorders, with emerging novel therapeutic indications each year. [...]
2020 - 10.3390/toxins12080491
Toxins, Vol. 12 (july 2020)  
Detailed record - Creative Commons
2.
21 p, 946.8 KB Chronic electrical stimulation reduces hyperalgesia and associated spinal changes induced by peripheral nerve injury / López-Álvarez, Víctor M. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Cobianchi, Stefano (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Objectives: We aimed to investigate if different protocols of electrical stimulation following nerve injury might improve neuropathic pain outcomes and modify associated plastic changes at the spinal cord level. [...]
2019 - 10.1111/ner.12927
Neuromodulation, 2019  
Detailed record -
3.
24 p, 3.2 MB Neuroprotective Effects of Exercise Treatments After Injury : The Dual Role of Neurotrophic Factors / Cobianchi, Stefano (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Arbat-Plana, Ariadna (Universitat Autònoma de Barcelona. Institut de Neurociències) ; López-Álvarez, Víctor M. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Shared connections between physical activity and neuroprotection have been studied for decades, but the mechanisms underlying this effect of specific exercise were only recently brought to light. Several evidences suggest that physical activity may be a reasonable and beneficial method to improve functional recovery in both peripheral and central nerve injuries and to delay functional decay in neurodegenerative diseases. [...]
2017 - 10.2174/1570159X14666160330105132
Current neuropharmacology, Vol. 15 (may 2017) , p. 495-518  
Detailed record - Creative Commons
4.
30 p, 1.2 MB Monoaminergic descending pathways contribute to modulation of neuropathic pain by increasing-intensity treadmill exercise after peripheral nerve injury / López-Álvarez, Víctor M. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Puigdomenech Poch, Maria (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Cobianchi, Stefano (Universitat Autònoma de Barcelona. Institut de Neurociències)
This study characterizes the impact of increasing-intensity treadmill exercise (iTR) on noradrenergic (NE) and serotonergic (5HT) modulation of neuropathic pain. Following sciatic nerve transection and repair (SNTR) rats developed significant mechanical and thermal hyperalgesia that was partially prevented by iTR performed during the first 2 weeks after injury. [...]
2018 - 10.1016/j.expneurol.2017.10.007
Experimental Neurology, Vol. 299, Part A (January 2018) , p. 42-55  
Detailed record - Creative Commons
5.
24 p, 1.4 MB Tubulization with chitosan guides for the repair of long gap peripheral nerve injury in the rat / Gonzalez Perez, M. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Cobianchi, Stefano (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Geuna, Stefano (Neuroscience institute Cavalieri Ottolenghi) ; Barwig, Christina (Medovent GmbH) ; Freier, Thomas (Medovent GmbH) ; Udina i Bonet, Esther (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Biosynthetic guides can be an alternative to nerve grafts for reconstructing severely injured peripheral nerves. The aim of this study was to evaluate the regenerative capability of chitosan tubes to bridge critical nerve gaps (15 mm long) in the rat sciatic nerve compared with silicone (SIL) tubes and nerve autografts (AGs). [...]
2015 - 10.1002/micr.22362
Microsurgery, Vol. 35, Issue 4 (May 2015) , p. 300-308  
Detailed record -
6.
16 p, 1.6 MB Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse / Manassero, Giusi (University of Turin. Department of Neuroscience (Torí, Itàlia)) ; Repetto, Ivan E. (Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (Torí, Itàlia)) ; Cobianchi, Stefano (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Valsecchi, Valeria (University of Turin. Department of Neuroscience (Torí, Itàlia)) ; Bonny, Christophe (Lausanne University Hospital) ; Rossi, Ferdinando (University of Turin. Department of Neuroscience (Torí, Itàlia)) ; Vercelli, Alessandro (University of Turin. Department of Neuroscience (Torí, Itàlia))
Background: Current tools for analgesia are often only partially successful, thus investigations of new targets for pain therapy stimulate great interest. Consequent to peripheral nerve injury, c-Jun N-terminal kinase (JNK) activity in cells of the dorsal root ganglia (DRGs) and spinal cord is involved in triggering neuropathic pain. [...]
2012 - 10.1186/1744-8069-8-39
Molecular pain, Vol. 8, N. 39 (May 2012) , p. 1-16
3 documents
Detailed record - Creative Commons

Research literature 1 records found  
1.
251 p, 5.3 MB Activity-dependent treatments for neuropathic pain / López Álvarez, Víctor Manuel ; Navarro, X. (Xavier), (Xavier) dir. ; Cobianchi, Stefano, dir. ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia ; Universitat Autònoma de Barcelona. Institut de Neurociències
El inicio y el mantenimiento del dolor neuropático después de una lesión de nervio periférico implica muchos mecanismos tales como cambios en la transducción, sensibilización central o periférica y numerosos cambios plásticos a nivel central. [...]
The onset and maintenance of neuropathic pain following a peripheral nerve injury involves many mechanisms such as changes in transduction, central or peripheral sensitization, and numerous plastic changes at the central level. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2017.  
Detailed record - Creative Commons

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