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1.
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12 p, 831.3 KB |
Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
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Lombaers, Marike S. (Radboud Institute of Health Sciences (Holanda)) ;
Cornel, Karlijn M. C. (Department of Obstetrics and Gynecology, University of Toronto) ;
Visser, Nicole C. M. (Department of Pathology, Eurofins PAMM (Països Baixos)) ;
Bulten, Johan (Radboud University Medical Center (Holanda)) ;
Küsters-Vandevelde, Heidi V. N. (Department of Pathology, Canisius-Wilhelmina Hospital (Països Baixos)) ;
Amant, Frederic (The Netherlands Cancer Institute (Països Baixos)) ;
Boll, Dorry (Department of Gynecology, Catharina Hospital (Països Baixos)) ;
Bronsert, Peter (University Medical Center) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Geomini, Peggy M. A. J. (Department of Obstetrics and Gynecology, Maxima Medical Centre (Països Baixos)) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
van Hamont, Dennis (Department of Obstetrics and Gynecology, Amphia Hospital (Països Baixos)) ;
Huvila, Jutta (Department of Pathology, University of Turku (Països Baixos)) ;
Krakstad, Camilla (Department of Clinical Science, University of Bergen) ;
Kraayenbrink, Arjan A. (Department of Obstetrics and Gynaecology, Rijnstate Hospital (Països Baixos)) ;
Koskas, Martin (Department of Obstetrics and Gynecology, Bichat-Claude Bernard Hospital (França)) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Matías-Guiu, Xavier (Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova) ;
Ngo, Huy (Department of Obstetrics and Gynecology, Elkerliek Hospital (Països Baixos)) ;
Pijlman, Brenda M. (Department of Obstetrics and Gynecology, Jeroen Bosch Hospital, 5223 GZ 's-Hertogenbosch (Països Baixos)) ;
Vos, Maria Caroline (Department of Obstetrics and Gynecology, Elisabeth-TweeSteden Hospital (Països Baixos)) ;
Weinberger, Vit (Department of Gynecology and Obstetrics, University Hospital Brno, Faculty of Medicine, Masaryk University (República Txeca)) ;
Snijders, Marc P. L. M. (Department of Obstetrics and Gynecology, Canisius-Wilhelmina Hospital (Països Baixos)) ;
van Koeverden, Sebastiaan W. (Department of Radiology and Nuclear Medicine, Radboud University Medical Center (Països Baixos)) ;
Haldorsen, Ingfrid S. (Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway) ;
Reijnen, Casper (Department of Radiation Oncology, Radboud University Medical Center (Països Baixos)) ;
Pijnenborg, Johanna M. A. (Radboud Institute of Health Sciences (Països Baixos)) ;
Universitat Autònoma de Barcelona
Patients with high-grade uterine cancer (UC) have a risk of around 20% of the cancer spreading to the lymph nodes, while this is only around 10% in patients with low-grade uterine cancer. CA125 is a marker that can be detected in blood and is associated with increased tumor spread. [...]
2023 -  10.3390/cancers15092605
Cancers, Vol. 15 (may 2023)
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2.
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15 p, 1.9 MB |
In silico Approach for Validating and Unveiling New Applications for Prognostic Biomarkers of Endometrial Cancer
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Coll de la Rubia, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Garcia, Elena (Luxembourg Institute of Health) ;
Dittmar, Gunnar (Luxembourg Institute of Health) ;
Nazarov, Petr V. (Luxembourg Institute of Health) ;
Bebia, Vicente (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Endometrial cancer (EC) mortality is directly associated with the presence of poor prognostic factors. Molecular prognostic factors have been identified, but none are used in clinical practice due to lack of validation studies. [...]
2021 - 10.3390/cancers13205052
Cancers, Vol. 13 (october 2021)
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3.
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22 p, 3.0 MB |
Genomic Validation of Endometrial Cancer Patient-Derived Xenograft Models as a Preclinical Tool
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Villafranca-Magdalena, Beatriz (Universitat Autònoma de Barcelona) ;
Masferrer-Ferragutcasas, Carina (Universitat Autònoma de Barcelona) ;
López-Gil, Carlos (Universitat Autònoma de Barcelona) ;
Coll de la Rubia, Eva (Universitat Autònoma de Barcelona) ;
Rebull, Marta (Universitat Autònoma de Barcelona) ;
Parra, Genis (Centre de Regulació Genòmica) ;
García, Ángel (Hospital Universitari Vall d'Hebron) ;
Reques, Armando (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Vall d'Hebron Institut d'Oncologia) ;
Colás Ortega, Eva (Universitat Autònoma de Barcelona) ;
Gil-Moreno, Antonio 1965- (Vall d'Hebron Institut d'Oncologia) ;
Moiola, Cristian Pablo (Universitat Autònoma de Barcelona)
Endometrial cancer (EC) is the second most frequent gynecological cancer worldwide. Although improvements in EC classification have enabled an accurate establishment of disease prognosis, women with a high-risk or recurrent EC face a dramatic situation due to limited further treatment options. [...]
2022 - 10.3390/ijms23116266
International journal of molecular sciences, Vol. 23 (june 2022)
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4.
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17 p, 2.5 MB |
Cervical Fluids Are a Source of Protein Biomarkers for Early, Non-Invasive Endometrial Cancer Diagnosis
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Martinez-Garcia, Elena (Luxembourg Institute of Health) ;
Coll de la Rubia, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lesur, Antoine (Luxembourg Institute of Health) ;
Dittmar, Gunnar (University of Luxembourge) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Abnormal uterine bleeding (AUB) is the main symptom of endometrial cancer (EC), but it is highly nonspecific. This represents a huge burden for women's health, since all women presenting with bleeding will undergo sequential invasive tests, avoidable in 90-95% of those women who do not have EC. [...]
2023 - 10.3390/cancers15030911
Cancers, Vol. 15 (january 2023)
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5.
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10 p, 887.3 KB |
Relevance of Molecular Profiling in Patients With Low-Grade Endometrial Cancer
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Vrede, Stephanie W. (Canisius-Wilhelmina Hospital) ;
Kasius, Jenneke (Amsterdam Medical Centers and Center of Gynecologic Oncology Amsterdam) ;
Bulten, Johan (Radboud University Medical Center) ;
Teerenstra, Steven (Radboud University Medial Center) ;
Huvila, Jutta (University of Turku) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Boll, Dorry (Catharina Hospital Eindhoven, the Netherlands) ;
Vos, Maria Caroline (Elisabeth-Tweesteden Hospital) ;
van Altena, Anne M. (Radboud University Medical Center) ;
Asberger, Jasmin (Medical Center-University of Freiburg) ;
Sweegers, Sanne (Radboud University Medical Center) ;
van Weelden, Willem Jan (Canisius-Wilhelmina Hospital) ;
van der Putten, Louis J. M. (Radboud University Medical Center) ;
Amant, Frederic (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Visser, Nicole C. M. (Stichting Laboratory for Pathology and Medical Microbiology) ;
Snijders, Marc P. L. M. (Canisius-Wilhelmina Hospital) ;
Küsters-Vandevelde, Heidi V. N. (Canisius Wilhelmina Hospital) ;
Kruitwagen, Roy (Maastricht University Medical Center) ;
Matias-Guiu, Xavier (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Weinberger, Vit (University Hospital in Brno and Masaryk University) ;
Reijnen, Casper (Radboud University Medical Center) ;
Pijnenborg, Johanna M. A. (Radboud University Medical Center) ;
Universitat Autònoma de Barcelona
Is tumor molecular profile associated with outcomes among patients with low-grade endometrial cancer? In this retrospective multicenter cohort study of 393 patients, outcomes for patients with low-grade endometrial cancer were not associated with molecular subgroup. [...]
2022 - 10.1001/jamanetworkopen.2022.47372
JAMA network open, Vol. 5 (december 2022)
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6.
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20 p, 10.3 MB |
The ERK5/NF-κB signaling pathway targets endometrial cancer proliferation and survival
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Diéguez-Martínez, Nora (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Espinosa-Gil, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Yoldi Salinas, Guillermo (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Megías-Roda, Elisabet (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bolinaga-Ayala, Idoia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Viñas-Casas, Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Gorgisen, Gokhan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Domingo-Ortí, Inés (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pérez-Montoyo, Héctor (Ability Pharmaceuticals (Cerdanyola del Vallès)) ;
Bayascas Ramírez, José Ramón (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dolcet, Xavier (Universitat de Lleida) ;
Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Endometrial cancer (EC) is the most common type of gynecologic cancer in women of developed countries. Despite surgery combined with chemo-/radiotherapy regimens, overall survival of patients with high-risk EC tumors is poor, indicating a need for novel therapies. [...]
2022 - 10.1007/s00018-022-04541-6
Cellular and Molecular Life Sciences, Vol. 79 (2022) , p. 524
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7.
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16 p, 5.4 MB |
Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression
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Mota, Alba (Universidad Autónoma de Madrid. Departamento de Bioquímica) ;
Oltra, Sara S. (Centro de Investigación Biomédica en Red de Cáncer) ;
Selenica, Pier (Memorial Sloan Kettering Cancer Center) ;
Moiola, Cristian Pablo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casas-Arozamena, Carlos (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
López-Gil, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Diaz, Eva (MD Anderson International Foundation) ;
Gatius, Sonia (Hospital Arnau de Vilanova (València)) ;
Ruiz-Miro, María (Biobank (Lleida)) ;
Calvo, Ana (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Rojo-Sebastián, Alejandro (MD Anderson Cancer Center) ;
Hurtado Blanco, P (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Piñeiro, Health Research Institute of Santiago de Compostela ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Reis-Filho, Jorge S. (Memorial Sloan Kettering Cancer Center.) ;
Muinelo-Romay, Laura (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Abal Posada, Miguel (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Matias-Guiu, Xavier (Universitat de Lleida) ;
Weigelt, Britta (Memorial Sloan Kettering Cancer Center. Department of Pathology) ;
Moreno-Bueno, Gema (Centro de Investigación Biomédica en Red de Cáncer) ;
Universitat Autònoma de Barcelona
Analyzing different tumor regions by next generation sequencing allows the assessment of intratumor genetic heterogeneity (ITGH), a phenomenon that has been studied widely in some tumor types but has been less well explored in endometrial carcinoma (EC). [...]
2022 - 10.1038/s41388-022-02221-0
Oncogene, Vol. 41 (february 2022) , p. 1835-1850
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8.
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16 p, 1.3 MB |
Molecular Markers for Prostate Cancer in Formalin-Fixed Paraffin-Embedded Tissues
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Sequeiros, Tamara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montes, Melania (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Olivan, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rigau, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Torres, Inés (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Morote Robles, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Reventós Puigjaner, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Doll, Andreas (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Prostate cancer (PCa) is the most frequently diagnosed type of cancer in developed countries. The decisive method of diagnosis is based on the results of biopsies, morphologically evaluated to determine the presence or absence of cancer. [...]
2013 - 10.1155/2013/283635
BioMed Research International, Vol. 2013 (november 2013)
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9.
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13 p, 2.0 MB |
Metabolomic and Lipidomic Profiling Identifies The Role of the RNA Editing Pathway in Endometrial Carcinogenesis
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Altadill, Tatiana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dowdy, Tyrone M. (Georgetown University Medical Center) ;
Gill, Kirandeep (Georgetown University Medical Center) ;
Reques, Armando (Hospital Universitari Vall d'Hebron) ;
Menon, Smrithi S. (Georgetown University Medical Center) ;
Moiola, Cristian Pablo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lopez-Gil, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Coll de la Rubia, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Matias-Guiu, Xavier (Institut d'Investigació Biomèdica de Bellvitge) ;
Cabrera Díaz, Silvia (Vall d'Hebron Institut d'Oncologia) ;
Garcia, Angel (Hospital Universitari Vall d'Hebron) ;
Reventos, Jaume (Universitat Internacional de Catalunya) ;
Byers, Stephen W. (Georgetown-Lombardi Comprehensive Cancer Center) ;
Gil-Moreno, Antonio 1965- (Vall d'Hebron Institut d'Oncologia) ;
Cheema, Amrita K. (Georgetown-Lombardi Comprehensive Cancer Center) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Endometrial cancer (EC) remains the most common malignancy of the genital tract among women in developed countries. Although much research has been performed at genomic, transcriptomic and proteomic level, there is still a significant gap in the metabolomic studies of EC. [...]
2017 - 10.1038/s41598-017-09169-2
Scientific reports, Vol. 7 (august 2017)
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10.
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26 p, 789.4 KB |
Small-Molecule Inhibitors (SMIs) as an Effective Therapeutic Strategy for Endometrial Cancer
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Megino-Luque, Cristina (Centro de Investigación Biomédica en Red de Cáncer) ;
Moiola, Cristian Pablo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Molins-Escuder, Clara (Universitat de Lleida) ;
López-Gil, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Matias-Guiu, Xavier (Institut d'Investigació Biomèdica de Bellvitge) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Eritja, Núria (Institut de Recerca Biomèdica de Lleida) ;
Universitat Autònoma de Barcelona
Patients diagnosed with endometrial cancer (EC), the most common gynaecological malignancy in women worldwide, cope with a disease associated with poor prognosis and limited treatment options after first-line therapy when it reaches an advanced or metastatic stage. [...]
2020 - 10.3390/cancers12102751
Cancers, Vol. 12 (september 2020)
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