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1.
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23 p, 1.1 MB |
The Behavioral and Psychological Symptoms of Dementia in down Syndrome Scale (BPSD-DS II) : Optimization and Further Validation
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Dekker, Alain D. (Department of Practice-oriented Scientific Research (PWO). Alliade Care Group) ;
Ulgiati, Aurora M. (Department of Practice-oriented Scientific Research (PWO). Alliade Care Group) ;
Groen, Henk (Department of Epidemiology. University of Groningen. University Medical Center Groningen) ;
Boxelaar, Vicent A. (Center for Information Technology. University of Groningen) ;
Sacco, Silvia (Institut Jérôme Lejeune) ;
Falquero, Ségolène (Institut Jérôme Lejeune) ;
Carfi, Angelo (Policlinico Universitario Agostino Gemelli IRCCS (Roma, Itàlia)) ;
Di Paola, Antonella (Department of Geriatrics. Fondazione Policlinico Universitario Gemelli Irccs) ;
Benejam, Bessy (Barcelona Down Medical Center. Fundació Catalana Síndrome de Down) ;
Valldeneu, Silvia (Institut d'Investigació Biomèdica Sant Pau) ;
Fopma, Roelie (Department of Practice-oriented Scientific Research (PWO). Alliade Care Group) ;
Oosterik, Marjo (Aveleijn) ;
Hermelink, Marloes (De Twentse Zorgcentra) ;
Beugelsdijk, Gonny (Ipse de Bruggen) ;
Schippers, Mieke (Ipse de Bruggen) ;
Henstra, Hepie (Nieuw Woelwijck) ;
Scholten-Kuiper, Martine (Philadelphia Zorg) ;
Willink-Vos, Judith (Severinus) ;
De Ruiter, Lisa (Sherpa) ;
Willems, Liesbeth (Sprank) ;
Loonstra-De Jong, Anneke (Vanboeijen) ;
Coppus, Antonia (Dichterbij) ;
Tollenaere, Marleen (Department of Neurology and Memory Clinic. Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Onder, Graziano (Department of Cardiovascular. Endocrine-metabolic Diseases and Aging. Istituto Superiore di Sanitá) ;
Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ;
Van Dam, Debby (Laboratory of Neurochemistry and Behavior. Department of Biomedical Sciences and Institute Born-Bunge. University of Antwerp) ;
De Deyn, Peter Paul (University Hospital Antwerp (Bèlgica))
Background: People with Down syndrome (DS) are at high risk to develop Alzheimer's disease dementia (AD). Behavioral and psychological symptoms of dementia (BPSD) are common and may also serve as early signals for dementia. [...]
2021 -  10.3233/JAD-201427
Journal of Alzheimer's disease, Vol. 81 Núm. 4 (2021) , p. 1505-1527
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2.
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10 p, 344.1 KB |
Markers of early changes in cognition across cohorts of adults with down syndrome at risk of alzheimer's disease
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Aschenbrenner, A.J. (Washington University in St. Louis. Department of Neurology) ;
Asaad Baksh, R. (The London Down Syndrome (LonDownS) Consortium) ;
Benejam, Bessy (Barcelona Down Medical Center. Fundació Catalana Síndrome de Down) ;
Beresford-Webb, J.A. (Cambridge Intellectual and Developmental Disabilities Research Group. Department of Psychiatry. University of Cambridge) ;
Coppus, Antonia (Department of Primary and Community Care. Radboud University Medical Center) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Handen, Benjamin L (Department of Psychiatry. University of Pittsburgh) ;
Hartley, S. (Department of Human Development & Family Studies. University of Wisconsin-Madison) ;
Head, E. (Department of Pathology & Laboratory Medicine. University of California) ;
Jaeger, J. (Deptment of Psychiatry and Behavioral Sciences. Albert Einstein College of Medicine) ;
Levin, J. (Munich Cluster for Systems Neurology (SyNergy)) ;
Loosli, S.V. (Department of Neurology. Ludwig-Maximilians-UniversitätMünchen) ;
Rebillat, A.S. (Jerome Lejeune Institute) ;
Sacco, S. (Jerome Lejeune Institute) ;
Schmitt, F.A. (Departments of Neurology. Neurosurgery. Behavioral Science. Psychology. Psychiatry. University of Kentucky) ;
Thurlow, K.E. (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Zaman, S. (Cambridgeshire & Peterborough NHS Foundation Trust) ;
Hassenstab, J. (Washington University in St. Louis. Department of Neurology) ;
Strydom, A. (South London and the Maudsley NHS Foundation Trust)
Introduction: Down syndrome (DS), a genetic variant of early onset Alzheimer's disease (AD), lacks a suitable outcome measure for prevention trials targeting predementia stages. Methods: We used cognitive test data collected in several longitudinal aging studies internationally from 312 participants with DS without dementia to identify composites that were sensitive to change over time. [...]
2021 - 10.1002/dad2.12184
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 13 Núm. 1 (2021) , p. e12184
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28 p, 1.9 MB |
The clinical and neuropathological features of sporadic (Late-onset) and genetic forms of alzheimer's disease
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Rujeedawa, T. (Cambridge Intellectual & Developmental Disabilities Research Group. Department of Psychiatry. University of Cambridge) ;
Félez, E.C. (Cambridge Intellectual & Developmental Disabilities Research Group. Department of Psychiatry. University of Cambridge) ;
Clare, I.C.H. (Cambridgeshire and Peterborough Foundation NHS Trust) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Strydom, A. (South London and the Maudsley NHS Foundation Trust. The LonDowns Consortium) ;
Rebillat, A.S. (Geriatrics. Institut Jérôme Lejeune) ;
Coppus, Antonia (Department of Primary and Community Care (149 ELG). Radboud University Nijmegen Medical Center) ;
Levin, J. (Munich Cluster for Systems Neurology (SyNergy)) ;
Zaman, S.H. (Cambridgeshire and Peterborough Foundation NHS Trust) ;
Universitat Autònoma de Barcelona
The purpose of this review is to compare and highlight the clinical and pathological aspects of genetic versus acquired Alzheimer's disease: Down syndrome-associated Alzheimer's disease in (DSAD) and Autosomal Dominant Alzheimer's disease (ADAD) are compared with the late-onset form of the disease (LOAD). [...]
2021 - 10.3390/jcm10194582
Journal of clinical medicine, Vol. 10 Núm. 19 (October 2021) , p. 4582
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4.
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16 p, 930.6 KB |
Assessing general cognitive and adaptive abilities in adults with Down syndrome : a systematic review
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Hamburg, Sarah (The London Down Syndrome Consortium (LonDownS), London, UK) ;
Lowe, Bryony (Loughborough University. Department of Psychology) ;
Startin, Carla Marie (The London Down Syndrome Consortium (LonDownS), London, UK) ;
Padilla, Concepción (Department of Psychiatry, Herchel Smith Building for Brain & Mind Sciences, Forvie Site, Robinson Way, Cambridge, CB2 0SZ UK) ;
Coppus, Antonia (Radboud University Medical Center. Department of Primary and Community Care) ;
Silverman, Wayne (University of California. Department of Pediatrics) ;
Fortea, Juan (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Zaman, Shahid (Department of Psychiatry, Herchel Smith Building for Brain & Mind Sciences, Forvie Site, Robinson Way, Cambridge, CB2 0SZ UK) ;
Head, Elizabeth (University of Kentucky. Sanders-Brown Center on Aging) ;
Handen, Benjamin L. (University of Pittsburgh School of Medicine. Department of Psychiatry) ;
Lott, Ira (University of California. Departments of Pediatrics and Neurology) ;
Song, Weihong (The University of British Columbia. Townsend Family Laboratories, Department of Psychiatry) ;
Strydom, André (The London Down Syndrome Consortium (LonDownS), London, UK)
NOUAB.
Measures of general cognitive and adaptive ability in adults with Down syndrome (DS) used by previous studies vary substantially. This review summarises the different ability measures used previously, focusing on tests of intelligence quotient (IQ) and adaptive behaviour (AB), and where possible examines floor effects and differences between DS subpopulations. [...]
2019 - 10.1186/s11689-019-9279-8
Journal of Neurodevelopmental Disorders, Vol. 11 (august 2019)
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5.
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11 p, 1.2 MB |
Alzheimer's disease in Down syndrome : An overlooked population for prevention trials
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Strydom, André (South London and Maudsley NHS Foundation Trust) ;
Coppus, Antonia (Department of Primary and Community Care, Radboud University Medical Center, Nijmegen) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Danek, Adrian (Ludwig-Maximilians-Universität München) ;
Fortea, Juan (Fundació Catalana Síndrome de Down) ;
Hardy, John (Reta Lila Weston Institute, Institute of Neurology, University College London) ;
Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) site Munich) ;
Nuebling, Georg (Ludwig-Maximilians-Universität München) ;
Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ;
Ritchie, Craig (Centre for Clinical Brain Sciences. University of Edinburgh) ;
van Duijn, Cornelia (Department of Epidemiology, Erasmus Medical Centre, Rotterdam) ;
Zaman, Shahid (Cambridge University Hospitals NHS Foundation Trust (Regne Unit)) ;
Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ;
Universitat Autònoma de Barcelona
The discovery that adults with Down syndrome (DS) have neuropathological features identical to individuals with sporadic Alzheimer's disease (AD) played a key role in the identification of the amyloid precursor protein gene on chromosome 21 and resulted in the amyloid cascade hypothesis. [...]
2018 - 10.1016/j.trci.2018.10.006
Alzheimer's & dementia, Vol. 4 (december 2018) , p. 703-713
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6.
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23 p, 1.3 MB |
The behavioral and psychological symptoms of dementia in Down syndrome (BPSD-DS) scale : comprehensive assessment of psychopathology in Down syndrome
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Dekker, Alain D. (Universitair Medisch Centrum Groningen) ;
Sacco, Silvia (Institut Jérôme Lejeune) ;
Carfi, Angelo (Universitá Cattolica del Sacro Cuore) ;
Benejam, Bessy (Fundació Catalana Síndrome de Down) ;
Vermeiren, Yannick (Universitair Medisch Centrum Groningen) ;
Beugelsdijk, Gonny (Ipse de Bruggen) ;
Schippers, Mieke (Ipse de Bruggen) ;
Hassefras, Lyanne (Ipse de Bruggen) ;
Eleveld, José (Cosis (Groningen)) ;
Grefelman, Sharina (Cosis (Groningen)) ;
Fopma, Roelie (Talant (Heerenveen)) ;
Bomer-Veenboer, Monique (Pameijer (Rotterdam)) ;
Botí, M (Fundació Catalana Síndrome de Down) ;
Oosterling, G. Danielle E. (Aveleijn (Borne)) ;
Scholten, Esther (Elver (Nieuw-Wehl)) ;
Tollenaere, Marleen (Institute Born-Bunge) ;
Checkley, Laura (University College London. Division of Psychiatry) ;
Strydom, André (University College London. Division of Psychiatry) ;
Van Goethem, Gert (Het GielsBos (Gierle)) ;
Onder, Graziano (Universitá Cattolica del Sacro Cuore) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
zu Eulenburg, Christine (Universitair Medisch Centrum Groningen) ;
Coppus, Antonia (Dichterbij (Gennep)) ;
Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ;
Fortea, Juan (Fundació Catalana Síndrome de Down) ;
De Deyn, Peter Paul (Universitair Medisch Centrum Groningen) ;
Universitat Autònoma de Barcelona
People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. [...]
2018 - 10.3233/JAD-170920
Journal of Alzheimer's disease, Vol. 63, issue 2 (2018) , p. 797-819
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