1.
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15 p, 1.7 MB |
Article targeting pro-oxidant iron with deferoxamine as a treatment for ischemic stroke : safety and optimal dose selection in a randomized clinical trial
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Millán, Mónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
de la Ossa Pérez, Natàlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Reverté, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Costa, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Giner, Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Silva, Yolanda (Hospital Universitari de Girona Doctor Josep Trueta) ;
Sobrino, Tomás (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Rodríguez-Yáñez, Manuel (Hospital Clínico Universitario. Departamento de Neurología) ;
Nombela, Florentino (Hospital Universitario de la Princesa (Madrid)) ;
Campos, Francisco (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Serena, Joaquín (Hospital Universitari de Girona Doctor Josep Trueta) ;
Vivancos, José (Hospital Universitario de la Princesa (Madrid)) ;
Martí-Sistac, Octavi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
A role of iron as a target to prevent stroke-induced neurodegeneration has been recently revisited due to new evidence showing that ferroptosis inhibitors are protective in experimental ischemic stroke and might be therapeutic in other neurodegenerative brain pathologies. [...]
2021 - 10.3390/antiox10081270
Antioxidants, Vol. 10, p. 1270
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2.
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10 p, 962.7 KB |
The use and adherence of oral anticoagulants in Primary Health Care in Catalunya, Spain : a real-world data cohort study
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Giner-Soriano, Maria (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Gomez-Lumbreras, Ainhoa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Prat-Vallverdú, Oriol (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Quijada-Manuitt, Mª Angeles (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Morros, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Universitat Autònoma de Barcelona
We aimed to describe sociodemographic, comorbidities, co-medication and risk of thromboembolic events and bleeding in patients with NVAF initiating oral anticoagulants (OAC) for stroke prevention, and to estimate adherence and persistence to OAC. [...]
2020 - 10.1016/j.aprim.2020.05.016
Atencion Primaria, Vol. 52 (august 2020) , p. 529-538
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3.
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7 p, 823.3 KB |
Adherence to reporting guidelines increases the number of citations : the argument for including a methodologist in the editorial process and peer-review
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Vilaró, Marta (Universitat Politècnica de Catalunya. BarcelonaTech) ;
Cortés, Jordi (Universitat Politècnica de Catalunya) ;
Selva O'Callaghan, Albert (Hospital Universitari Vall d'Hebron) ;
Urrutia, Agustín (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ribera, Jose-Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cardellach, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Basagaña, X (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Elmore, Matthew (Universitat Politècnica de Catalunya) ;
Vilardell, Miquel 1946- (Hospital Universitari Vall d'Hebron) ;
Altman, Douglas (University of Oxford, Botnar Research Centre. Centre for Statistics in Medicine) ;
González, José-Antonio (Universitat Politècnica de Catalunya) ;
Cobo, Erik (Medicina Clínica, Elsevier-Barcelona) ;
Universitat Autònoma de Barcelona
From 2005 to 2010, we conducted 2 randomized studies on a journal (Medicina Clínica), where we took manuscripts received for publication and randomly assigned them to either the standard editorial process or to additional processes. [...]
2019 - 10.1186/s12874-019-0746-4
BMC Medical Research Methodology, Vol. 19 (may 2019)
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4.
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11 p, 1.2 MB |
Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014 : Incidence and comorbidities of antidepressant initiators
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Forns, Joan (RTI Health Solutions. Epidemiology) ;
Pottegård, Anton (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Reinders, Tammo (Leibniz Institute for Prevention Research and Epidemiology-BIPS) ;
Poblador-Plou, Beatriz (Instituto de Investigación Sanitaria de Aragón) ;
Morros, Rosa (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Brandt, Lena (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Cainzos-Achirica, Miguel (Epidemiology. RTI Health Solutions) ;
Hellfritzsch, Maja (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Schink, Tania (Leibniz Institute for Prevention Research and Epidemiology-BIPS) ;
Prados-Torres, Alexandra (Instituto de Investigación Sanitaria de Aragón) ;
Giner-Soriano, Maria (Institut Català de la Salut) ;
Hägg, David (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Hallas, Jesper (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Jacquot, Emmanuelle (Pharmacoepidemiology Department. Les Laboratoires Servier) ;
Deltour, Nicolas (Pharmacoepidemiology Department. Les Laboratoires Servier) ;
Perez-Gutthann, S. (Epidemiology. RTI Health Solutions) ;
Pladevall-Vila, Manel (Epidemiology. RTI Health Solutions) ;
Reutfors, Johan (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital)
Background: We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009-2014 in Denmark, Germany, Spain, and Sweden. Methods: Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. [...]
2019 - 10.1016/j.jad.2019.02.010
Journal of Affective Disorders, Vol. 249 (April 2019) , p. 242-252
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5.
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13 p, 786.0 KB |
Risk of Acute Liver Injury in Agomelatine and Other Antidepressant Users in Four European Countries : A Cohort and Nested Case-Control Study Using Automated Health Data Sources
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Pladevall-Vila, Manel (Epidemiology. RTI Health Solutions) ;
Pottegård, Anton (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Schink, Tania (Leibniz Institute for Prevention Research and Epidemiology-BIPS) ;
Reutfors, Johan (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Morros, Rosa. (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Poblador-Plou, Beatriz (Instituto de Investigación Sanitaria de Aragón) ;
Timmer, Antje (Division of Epidemiology and Biometry. Medical Faculty. Carl von Ossietzky University) ;
Forns, Joan (Epidemiology. RTI Health Solutions) ;
Hellfritzsch, Maja (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Reinders, Tammo (Leibniz Institute for Prevention Research and Epidemiology-BIPS) ;
Hägg, David (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Giner-Soriano, Maria (Institut Català de la Salut) ;
Prados-Torres, Alexandra (Instituto de Investigación Sanitaria de Aragón) ;
Cainzos-Achirica, Miguel (Epidemiology. RTI Health Solutions) ;
Hallas, Jesper (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Brandt, Lena (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Aguado, Jaume (Epidemiology. RTI Health Solutions) ;
Perlemuter, Gabriel (INSERM U996) ;
Falissard, Bruno (CESP INSERM U1018. Université Paris-Saclay. Université Paris-Sud. UVSQ. APHP) ;
Castellsague, Jordi (Epidemiology. RTI Health Solutions) ;
Jacquot, Emmanuelle (Pharmacoepidemiology Department. Servier) ;
Deltour, Nicolas (Pharmacoepidemiology Department. Servier) ;
Perez-Gutthann, S. (Epidemiology. RTI Health Solutions)
Background: Agomelatine is a melatonin receptor agonist and serotonin 5-HT receptor antagonist indicated for depression in adults. Hepatotoxic reactions like acute liver injury (ALI) are an identified risk in the European risk management plan for agomelatine. [...]
2019 - 10.1007/s40263-019-00611-9
CNS Drugs, Vol. 33 Núm. 4 (april 2019) , p. 383-395
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6.
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11 p, 536.7 KB |
Validity of ICD-9 and ICD-10 codes used to identify acute liver injury : A study in three European data sources
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Forns, Joan (RTI Health Solutions) ;
Cainzos-Achirica, Miguel (RTI Health Solutions) ;
Hellfritzsch, Maja (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Morros, Rosa (Universitat Autònoma de Barcelona) ;
Poblador-Plou, Beatriz (Instituto de Investigación Sanitaria de Aragón) ;
Hallas, Jesper (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Giner-Soriano, Maria (Universitat Autònoma de Barcelona) ;
Prados-Torres, Alexandra (Instituto de Investigación Sanitaria de Aragón) ;
Pottegård, Anton (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Castellsague, Jordi (RTI Health Solutions) ;
Jacquot, Emmanuelle (Pharmacoepidemiology Department. Les Laboratoires Servier) ;
Deltour, Nicolas (Pharmacoepidemiology Department. Les Laboratoires Servier) ;
Perez-Gutthann, S. (RTI Health Solutions) ;
Pladevall-Vila, Manel (RTI Health Solutions)
Purpose: Validating cases of acute liver injury (ALI) in health care data sources is challenging. Previous validation studies reported low positive predictive values (PPVs). Methods: Case validation was undertaken in a study conducted from 2009 to 2014 assessing the risk of ALI in antidepressants users in databases in Spain (EpiChron and SIDIAP) and the Danish National Health Registers. [...]
2019 - 10.1002/pds.4803
Pharmacoepidemiology and Drug Safety, Vol. 28 Núm. 7 (july 2019) , p. 965-975
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8 p, 401.5 KB |
Impact of Medication Adherence on Mortality and Cardiovascular Morbidity : Protocol for a Population-Based Cohort Study
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Giner-Soriano, Maria (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Sotorra Figuerola, Gerard (Universitat Autònoma de Barcelona) ;
Cortés, Jordi (Universitat Autònoma de Barcelona) ;
Pera Pujadas, Helena (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Garcia-Sangenis, Ana (Universitat Autònoma de Barcelona) ;
Morros, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Cardiovascular disease (CVD) is a group of disorders of the heart and blood vessels, such as coronary heart disease (CHD), cerebrovascular disease, and peripheral artery disease. CVD is the leading threat to global health, whether measured by mortality, morbidity, or economic cost. [...]
2018 - 10.2196/resprot.8121
JMIR Research Protocols, Vol. 7, Issue 3 (March 2018) , art. e73
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