Home > Search Results: Cruz Saez, Alejandro
  Search Tips
Advanced Search
Search collections:
Sort by: Display results: Output format:
Results overview: Found 6 records in 0.01 seconds.
Articles, 5 records found
Research literature, 1 records found
Articles 5 records found  
1.
20 p, 15.9 MB Theoretical Study of the Arachidonic Acid Conversion into Leukotriene A4 Catalyzed by Human 5-Lipoxygenase : Hydroperoxidation and Epoxidation Mechanisms and Arachidonic Acid Active Site Access / Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Inflammation is at the base of many different diseases. Leukotrienes (LTs) are pro-inflammatory mediators derived from arachidonic acid (AA), which play significant roles in acute inflammation. Lipoxins are specialized pro-resolving mediators (SPMs), also formed from AA, that promote the resolution of acute inflammation. [...]
2024 - 10.1021/acscatal.3c04954
ACS catalysis, Vol. 14, Issue 2 (January 2024) , p. 637-656  
Detailed record - Creative Commons
2.
21 p, 4.8 MB Different Structures-Similar Effect : Do Substituted 5-(4-Methoxyphenyl)-1 H -indoles and 5-(4-Methoxyphenyl)-1 H -imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15? / Zhuravlev, Alexander (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; Aksenov, Vladislav (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry) ; Golovanov, Alexey (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Kuhn, Hartmut (Charite-University Medicine Berlin. Department of Biochemistry) ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ivanov, Igor (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies)
Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered this enzyme a target for pharmacological research. [...]
2023 - 10.3390/molecules28145418
Molecules, Vol. 28, Issue 14 (July 2023) , art. 5418  
Detailed record - Creative Commons
3.
36 p, 1.2 MB Accounting for the instantaneous disorder in the enzyme-substrate Michaelis complex to calculate the Gibbs free energy barrier of an enzyme reaction / Romero Tellez, Sonia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; Masgrau, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Departament de Química)
Many enzyme reactions present instantaneous disorder. These dynamic fluctuations in the enzyme-substrate Michaelis complexes generate a wide range of energy barriers that cannot be experimentally observed, but that determine the measured kinetics of the reaction. [...]
2021 - 10.1039/d1cp01338f
Physical Chemistry Chemical Physics, Vol. 23 (June 2021) , p. 13042-13054  
Detailed record -
4.
18 p, 31.6 MB Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15 / Ivanov, Igor (MIREA-Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; Zhuravlev, Alexander (MIREA-Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Di Venere, Almerinda (University of Tor Vergata. Department of Experimental Medicine) ; Nicolai, Eleonora (University of Tor Vergata. Department of Experimental Medicine) ; Stehling, Sabine (Charite-University Medicine Berlin. Institute of Biochemistry) ; Osca Lluch, José María (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Kuhn, Hartmut (Charite-University Medicine Berlin. Institute of Biochemistry)
Arachidonic acid lipoxygenases (ALOXs) have been suggested to function as monomeric enzymes, but more recent data on rabbit ALOX15 indicated that there is a dynamic monomer-dimer equilibrium in aqueous solution. [...]
2021 - 10.3390/ijms22063285
International journal of molecular sciences, Vol. 22, Issue 6 (March 2021) , art. 3285  
Detailed record - Creative Commons
5.
2 p, 518.8 KB Rol del residu Gln596 en el funcionament d'ALOX15, un enzim crucial per a la salut / Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Actualment se sap que malalties com l'arterioesclerosi o l'osteoporosi estan directament relacionades amb l'activitat de l'enzim ALOX15. Un estudi realitzat pel grup de recerca de l'àrea de Física-Química del Departament de Química de la UAB ha observat en diversos experiments l'important paper del residu Gln596 per a l'estabilitat d'aquest enzim, molt important per a controlar el desenvolupament d'aquesta mena d'afeccions.
Actualmente se sabe que enfermedades como la arterioesclerosis o la osteoporosis están relacionadas con la actividad de la enzima ALOX15. Un estudio realizado por el grupo de investigación del área de Física-Química del Departamento de Química de la UAB ha observado en varios experimentos el papel del residuo Gln596 para la estabilidad de dicha enzima, muy importante para controlar el desarrollo de este tipo de afecciones.
2020
UAB divulga, Desembre 2020
2 documents
Detailed record - Creative Commons

Research literature 1 records found  
1.
277 p, 15.7 MB Simulaciones biomoleculares de algunas enzimas relevantes en procesos inflamatorios : 15-LOX, 5-LOX y COX-2. Aplicación al estudio de mecanismos y al diseño de inhibidores / Cruz Saez, Alejandro ; Lluch López, Josep Maria, dir. ; González-Lafont, Àngels, dir.
Les Lipoxigenases (LOXs) i Ciclooxigenases (COXs) són dues famílies d'enzims que inicien la biosíntesis de compostos lipídics de senyalització que són crucials per a la salut humana i estan implicats en un gran nombre de malalties. [...]
Las Lipoxigenasas (LOXs) y Ciclooxigenasas (COXs) son dos familias de enzimas que inician la biosíntesis de compuestos lipídicos de señalización que son cruciales para la salud humana y están implicados en un gran número de enfermedades. [...]
Lipoxygenases (LOXs) and Cyclooxygenases (COXs) are two families of enzymes which initiate the biosynthesis of lipid signalling compounds that are crucial for human health and are implicated in a number of diseases. [...]
2022  
Detailed record -

Interested in being notified about new results for this query?
Set up a personal email alert or subscribe to the RSS feed.
UAB Digital Repository of Documents :: Search :: Submit :: Personalize :: Help
Powered by Invenio v1.1.6
Maintained by ddd.bib@uab.cat  :: Metadata license:
Working with