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9 p, 1.0 MB |
Cytotoxic NK cells phenotype and activated lymphocytes are the main characteristics of patients with alcohol-associated liver disease
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Zurera Egea, Coral (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Teniente Serra, Aina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Fuster, Daniel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Zuluaga Blanco, Yenny Paola (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
T cells, natural killer (NK) and NKT cells have opposing actions in the development of alcohol-associated liver fibrosis. We aimed to evaluate the phenotype of NK cells, NKT cells and activated T cells in patients with alcohol use disorder (AUD) according to the presence of advanced liver fibrosis (ALF). [...]
2023 -  10.1007/s10238-023-01121-1
Clinical and Experimental Medicine, Vol. 23, Num. 7 (november 2023) , p. 3539-3547
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10 p, 868.0 KB |
Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells
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Ternette, Nicola (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Yang, Hongbing (University of Oxford. Nuffield Department of Medicine) ;
Partridge, Thomas (University of Oxford. Nuffield Department of Medicine) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fischer, Roman (University of Oxford. Nuffield Department of Medicine) ;
Charles, Philip D. (University of Oxford. Nuffield Department of Medicine) ;
Dudek, Nadine L. (Monash University. Department of Biochemistry and Molecular Biology) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Crespo Casal, Manuel (Hospital Universitari Vall d'Hebron) ;
Fischer, William M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ;
Korber, Bette T. M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ;
Nielsen, Morten (Technical University of Denmark. Center for Biological Sequence Analysis) ;
Borrow, Persephone (University of Oxford. Nuffield Department of Medicine) ;
Purcell, Anthony W. (Monash University. Department of Biochemistry and Molecular Biology) ;
Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ;
Dorrell, Lucy (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Kessler, Benedikt M. (University of Oxford. Nuffield Department of Medicine) ;
Hanke, Tomáš (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Universitat Autònoma de Barcelona
Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High-throughput definition of HLA class I-associated immunopeptidomes by mass spectrometry is an increasingly important analytical tool to advance our understanding of the induction of T-cell responses against pathogens such as HIV-1. [...]
2015 - 10.1002/eji.201545890
European Journal of Immunology, Vol. 46 (november 2015) , p. 60-69
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22 p, 1.1 MB |
Type 1 diabetes prevention in NOD mice by targeting DPPIV/CD26 is associated with changes in CD8+T effector memory subset
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Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Julián, María Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrascal, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Colobrán Oriol, Roger (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teniente Serra, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández Sanmartin, Marco Antonio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Miñarro Alonso, Antoni (Universitat de Barcelona. Departament d'Estadística) ;
Ruiz de Villa, María del Carmen (Universitat de Barcelona. Departament d'Estadística) ;
Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
CD26 is a T cell activation marker consisting in a type II transmembrane glycoprotein with dipeptidyl peptidase IV (DPPIV) activity in its extracellular domain. It has been described that DPPIV inhibition delays the onset of type 1 diabetes and reverses the disease in non-obese diabetic (NOD) mice. [...]
2015 - 10.1371/journal.pone.0142186
PloS one, Vol. 10, Issue 11 (Novembre 2015) , p. e0142186
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21 p, 2.1 MB |
Natural Polymorphisms in Tap2 Influence Negative Selection and CD4:CD8 Lineage Commitment in the Rat
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Tuncel, Jonatan (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Haag, Sabrina (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Yau, Anthony C. (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Norin, Ulrika (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Baud, Amelie (Wellcome Trust Centre for Human Genetics (Oxford, Regne Unit)) ;
Lönnblom, Erik (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Maratou, Klio (Imperial College London) ;
Ytterberg, A. Jimmy (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Ekman, Diana (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Thordardottir, Soley (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Johannesson, Martina (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Gillett, Alan (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Stridh, Pernilla (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Jagodic, Maja (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Olsson, Tomas (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Zubarev, Roman (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
Mott, Richard (Wellcome Trust Centre for Human Genetics (Oxford, Regne Unit)) ;
Aitman, Timothy J. (Imperial College London) ;
Flint, Jonathan (Wellcome Trust Centre for Human Genetics (Oxford, Regne Unit)) ;
Holmdahl, Rikard (Karolinska Institutet (Estocolm, Suècia). Department of Medical Biochemistry and Biophysics) ;
EURATRANS Consortium
Genetic variation in the major histocompatibility complex (MHC) affects CD4∶CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved. [...]
2014 - 10.1371/journal.pgen.1004151
PLoS Genetics, Vol. 10 Issue 2 (February 2014) , p. e1004151
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11 p, 1.2 MB |
DNA Vaccination Partially Protects against African Swine Fever Virus Lethal Challenge in the Absence of Antibodies
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Argilaguet, Jordi 1977- (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Pérez Martín, Eva (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Nofrarías Espadamala, Miquel (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Gallardo, Carmina (Centro de Investigación en Sanidad Animal. CISA (Madrid, Espanya)) ;
Accensi Alemany, Francesc (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Lacasta, Anna (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Mora Salvatierra, Mercedes (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Ballester Devis, Maria (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Galindo Cardiel, Iván (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
López-Soria, Sergio (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Escribano, José M. ;
Reche, Pedro A. ;
Rodriguez, Fernando (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
The lack of available vaccines against African swine fever virus (ASFV) means that the evaluation of new immunization strategies is required. Here we show that fusion of the extracellular domain of the ASFV Hemagglutinin (sHA) to p54 and p30, two immunodominant structural viral antigens, exponentially improved both the humoral and the cellular responses induced in pigs after DNA immunization. [...]
2012 - 10.1371/journal.pone.0040942
PloS one, Vol. 7, Issue 9 (September 2012) , p. e40942
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